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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Gcgr
glucagon receptor
MGI:99572
70 phenotypes from 7 alleles in 8 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background
Annotated Term Reference
Gcgrem1Tshu/Gcgrem1Tshu
involves: C57BL/6J
decreased fasting circulating glucose level J:279017
Gcgrem2Smoc/Gcgrem2Smoc
C57BL/6J-Gcgrem2Smoc
abnormal liver physiology J:300368
abnormal pancreatic alpha cell morphology J:300368
decreased body fat mass J:300368
decreased fasting circulating glucose level J:300368
improved glucose tolerance J:300368
increased circulating glucagon level J:300368
increased liver weight J:300368
increased pancreas weight J:300368
increased pancreatic alpha cell proliferation J:300368
Gcgrtm1(GCGR)Kasu/Gcgrtm1(GCGR)Kasu
involves: 129S7/SvEvBrd * C57BL/6J
no abnormal phenotype detected J:58436
Gcgrtm1.1(KOMP)Vlcg/Gcgrtm1.1(KOMP)Vlcg
C57BL/6N-Gcgrtm1.1(KOMP)Vlcg/Ucd
abnormal bone structure J:211773
abnormal kidney morphology J:211773
decreased circulating insulin level J:211773
decreased fasting circulating glucose level J:211773
decreased mean corpuscular hemoglobin concentration J:211773
decreased total body fat amount J:211773
enlarged kidney J:211773
female infertility J:211773
improved glucose tolerance J:211773
increased blood urea nitrogen level J:211773
increased bone mineral content J:211773
increased circulating calcium level J:211773
increased circulating cholesterol level J:211773
increased kidney weight J:211773
increased lean body mass J:211773
increased mean corpuscular volume J:211773
increased startle reflex J:211773
male infertility J:211773
Gcgrtm1Jcp/Gcgrtm1Jcp
DBA/1LacJ-Gcgrtm1Jcp
abnormal exocrine gland morphology J:176507
abnormal pancreatic acinar cell morphology J:176507
abnormal pancreatic alpha cell differentiation J:176507
abnormal pancreatic alpha cell morphology J:176507
abnormal pancreatic islet morphology J:176507
decreased abdominal adipose tissue amount J:176507
decreased body weight J:176507
decreased circulating glucose level J:176507
decreased circulating insulin level J:176507
decreased liver weight J:176507
decreased subcutaneous adipose tissue amount J:176507
decreased susceptibility to age-related hepatic steatosis J:176507
decreased susceptibility to weight gain J:176507
enlarged pancreas J:176507
enlarged pancreatic islets J:176507
normal homeostasis/metabolism phenotype J:73926
increased circulating glucagon level J:73926, J:176507
increased glucagonoma incidence J:176507
increased pancreas tumor incidence J:176507
increased pancreatic beta cell proliferation J:176507
pancreatic islet hyperplasia J:176507
Gcgrtm1Mjch/Gcgrtm1Mjch
involves: 129 * C57BL/6J * SJL
decreased carbon dioxide production J:216393
decreased circulating insulin level J:208604
decreased food intake J:216393
decreased locomotor activity J:216393
decreased oxygen consumption J:216393
decreased susceptibility to diet-induced non-insulin dependent diabetes J:216393
decreased susceptibility to diet-induced obesity J:216393
improved glucose tolerance J:208604
increased bile salt level J:208604
increased circulating glucagon level J:208604
increased glucagon secretion J:208604
increased insulin sensitivity J:208604
increased pancreas weight J:208604
increased pancreatic alpha cell mass J:208604
increased pancreatic alpha cell number J:208604
increased pancreatic alpha cell proliferation J:208604
increased pancreatic beta cell mass J:208604
Gcgrtm1Mjch/Gcgrtm1Mjch
involves: 129/Sv * C57BL/6J * SJL
abnormal circulating amino acid level J:251829
abnormal pancreatic alpha cell morphology J:251829
decreased brown adipose tissue amount J:81772
decreased circulating glucose level J:81772
decreased circulating insulin level J:251829
decreased circulating leptin level J:81772
decreased gonadal fat pad weight J:81772
decreased interscapular fat pad weight J:81772
decreased litter size J:81772
decreased total body fat amount J:81772
decreased triglyceride level J:81772
normal endocrine/exocrine gland phenotype J:251829
hypoglycemia J:81772, J:251829
improved glucose tolerance J:81772
increased body mass index J:81772
increased circulating glucagon level J:81772, J:251829
increased circulating LDL cholesterol level J:81772
increased pancreatic alpha cell number J:251829
pancreatic islet hyperplasia J:81772, J:251829
postnatal lethality, incomplete penetrance J:81772
prenatal lethality, incomplete penetrance J:81772
Gcgrtm2.1Mjch/Gcgrtm2.1Mjch
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: C57BL/6 * DBA * SJL
abnormal glucose homeostasis J:208604
decreased circulating glucose level J:208604
decreased circulating insulin level J:208604
hypoglycemia J:208604
improved glucose tolerance J:208604
increased bile salt level J:208604
increased circulating glucagon level J:208604
increased insulin sensitivity J:208604
increased pancreas weight J:208604
increased pancreatic alpha cell number J:208604
increased pancreatic alpha cell proliferation J:208604
increased pancreatic beta cell mass J:208604

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory