Gcgr^tm1Jcp
Targeted Allele Detail

Summary

• Symbol: Gcgr^tm1Jcp
• Name: glucagon receptor; targeted mutation 1, Janice C Parker
• MGI ID: MGI:2179458
• Synonyms: GR-
• Gene: Gcgr Location: Chr11:120421525-120429812 bp, + strand Genetic Position: Chr11, 84.24 cM, cytoband E2
• Alliance: Gcgr^tm1Jcp page

Hyperplastic and dysplastic alpha cells in Gcgr^tm1Jcp/Gcgr^tm1Jcp mice at 5-7 months

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73926
• Parent Cell Line: DBA-252 (ES Cell)
• Strain of Origin: DBA/1LacJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced about 1.8 kb of sequence including exons 3-8, which correspond to amino acids 56-303. Isotope binding studies did not detect glucagon binding on liver membranes isolated from homozygous mutant mice. (J:73926)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Gcgr^tm1Jcp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gcgr Mutation: 5 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Pancreatic Neuroendocrine Tumors J:176507.

References

• Original: J:73926 Parker JC, et al., Glycemic control in mice with targeted disruption of the glucagon receptor gene. Biochem Biophys Res Commun. 2002 Jan 18;290(2):839-43
• All: 5 reference(s)