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Gcgr Gene Detail
Summary
  • Symbol
    Gcgr
  • Name
    glucagon receptor
  • Synonyms
    GR
  • Feature Type
    protein coding gene
  • IDs
    MGI:99572
    NCBI Gene: 14527
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:120421525-120429812 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.24 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    205 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99572
 protein coding gene Chr11:120420011-120429815 (+)
129S1/SvImJ ENSMUSG00200050414
 protein coding gene Chr11:117784919-117793204 (+)
A/J ENSMUSG00195024800
 protein coding gene Chr11:117459986-117468271 (+)
AKR/J ENSMUSG00220026583
 protein coding gene Chr11:117610393-117618678 (+)
BALB/cJ ENSMUSG00180051724
 protein coding gene Chr11:117752755-117761040 (+)
C3H/HeJ ENSMUSG00175037131
 protein coding gene Chr11:117710581-117718866 (+)
C57BL/6NJ ENSMUSG00215044278
 protein coding gene Chr11:117280500-117288785 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017524
 protein coding gene Chr11:116431227-116439422 (+)
CAST/EiJ ENSTCUG00005027378
 protein coding gene Chr11:117140058-117148369 (+)
CBA/J ENSMUSG00210048585
 protein coding gene Chr11:117424622-117432907 (+)
DBA/2J ENSMUSG00185021690
 protein coding gene Chr11:117737759-117746044 (+)
FVB/NJ ENSMUSG00205021317
 protein coding gene Chr11:117585486-117593771 (+)
JF1/MsJ ENSUMUG00000029960
 protein coding gene Chr11:118031652-118039926 (+)
LP/J ENSMUSG00230048317
 protein coding gene Chr11:118803528-118811813 (+)
NOD/ShiLtJ ENSMUSG00190043826
 protein coding gene Chr11:117808874-117817159 (+)
NZO/HlLtJ ENSMUSG00225049734
 protein coding gene Chr11:120952629-120960914 (+)
PWK/PhJ ENSLUMG00010023086
 protein coding gene Chr11:117547929-117556235 (+)
SPRET/EiJ ENSMSPG00010037454
 protein coding gene Chr11:118120653-118128539 (+)
WSB/EiJ ENSIUOG00005042974
 protein coding gene Chr11:117543344-117551629 (+)



Homology
more
  • Human Ortholog
    GCGR, glucagon receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCGR, glucagon receptor
  • Synonyms
    GGR, GL-R, MVAH
  • Links
    NCBI Gene ID: 2642
    UniProt: P47871

  • Chr Location
    17q25.3; chr17:81803105-81814023 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gcgr mouse models; 2 with human GCGR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 7 alleles in 8 genetic backgrounds
    9 phenotypes from multigenic genotypes
    3 images
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for a targeted mutation in this gene exhibit reduced blood glucose levels and increased plasma glucagon and amino acid levels associated with alpha-cell hyperplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    27
  • cDNA Data
    26
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025127 Ensembl Gene Model | MGI Sequence Detail 8288 C57BL/6J ±  kb
    transcript ENSMUST00000026119 Ensembl | MGI Sequence Detail 1957 Not Applicable  
    polypeptide ENSMUSP00000026119 Ensembl | MGI Sequence Detail 485 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007892 glucagon receptor
      (term hierarchy)
    • InterPro Domains
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR003290 GPCR, family 2, glucagon-like peptide-1/glucagon receptor
      IPR003291 GPCR, family 2, glucagon receptor
      IPR017981 GPCR, family 2-like, 7TM
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR050332 G-protein coupled receptor 2
    • GlyGen
      Q61606 5 sites
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 27
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16353
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 12
      Phenotypes 91
    • Earliest
      J:18259 Campos RV, et al., Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology. 1994 May;134(5):2156-64
    • Latest
      J:377495 Lasher AT, et al., Uncoupling Insulin Sensitivity From Longevity: A Sex-Dependent Effect of Hepatic Glucagon Signaling. Aging Cell. 2026 Jan;25(1):e70349
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory