Symbol
Name
ID

Gcgr
glucagon receptor
MGI:99572

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Type II diabetes mellitus	Insulin resistance	Increased glucagon level
Disease(s) Associated with GCGR	Type II diabetes mellitus	Insulin resistance	Increased glucagon level
Mahvash Disease
type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

increased glucagon secretion

decreased susceptibility to diet-induced obesity

abnormal circulating amino acid level

decreased fasting circulating glucose level

decreased circulating glucose level

hypoglycemia

increased circulating glucagon level

decreased circulating insulin level

decreased circulating leptin level

increased circulating LDL cholesterol level

increased circulating cholesterol level

increased circulating calcium level

increased blood urea nitrogen level

decreased carbon dioxide production

decreased oxygen consumption

abnormal glucose homeostasis

improved glucose tolerance

increased insulin sensitivity

increased bile salt level

decreased triglyceride level

decreased susceptibility to diet-induced non-insulin dependent diabetes

Availability

Mouse Genotype

Gcgr^em1Tshu/Gcgr^em1Tshu

Gcgr^em2Smoc/Gcgr^em2Smoc

Gcgr^{tm1.1(KOMP)Vlcg}/Gcgr^{tm1.1(KOMP)Vlcg}

Gcgr^tm1Jcp/Gcgr^tm1Jcp

Gcgr^tm1Mjch/Gcgr^tm1Mjch

Gcgr^tm2.1Mjch/Gcgr^tm2.1Mjch
Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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