Phenotypes Associated with This Genotype

Genotype
MGI:6690506

• Allelic Composition: Gcgr^em2Smoc/Gcgr^em2Smoc
• Genetic Background: C57BL/6J-Gcgr^em2Smoc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased body fat mass ( J:300368 )

• mice fed a standard chow diet exhibit decreased fat mass

• however, no differences are seen in body weight, growth rate, or food intake

cellular

increased pancreatic alpha cell proliferation ( J:300368 )

• mice fed a standard chow diet exhibit decreased inguinal fat weight

endocrine/exocrine glands

increased pancreatic alpha cell proliferation ( J:300368 )

• mice fed a standard chow diet exhibit decreased inguinal fat weight

abnormal pancreatic alpha cell morphology ( J:300368 )

• mice exhibit an alpha cell hyperplasia, with elevated alpha cell area and alpha cell proliferation

• however, no pancreatic neuroendocrine tumors are seen

increased pancreas weight ( J:300368 )

growth/size/body

decreased body fat mass ( J:300368 )

• mice fed a standard chow diet exhibit decreased fat mass

• however, no differences are seen in body weight, growth rate, or food intake

increased pancreas weight ( J:300368 )

increased liver weight ( J:300368 )

• liver weight is elevated in mice fed the standard chow diet

homeostasis/metabolism

decreased fasting circulating glucose level ( J:300368 )

• fasting blood glucose levels are lower in mice fed a standard chow diet

• however, fasting insulin levels in both standard chow diet and high fat diet fed mice are normal

increased circulating glucagon level ( J:300368 )

• fasting glucagon levels are increased

improved glucose tolerance ( J:300368 )

• in an oral glucose tolerance test, mice show a mild decrease in glucose excursion indicating improved glucose tolerance

• however, during insulin tolerance testing, blood glucose levels are similar to wild-type mice indicating that mice are not insulin resistant

liver/biliary system

increased liver weight ( J:300368 )

• liver weight is elevated in mice fed the standard chow diet

abnormal liver physiology ( J:300368 )

• mice fed a standard chow diet following a glucagon challenge show reduced hepatic glucagon sensitivity

• liver cell membranes exhibit decreased glucagon binding

• however, plasma aspartate aminotransferase, alanine aminotransferase, plasma total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein levels in mice fed both the standard chow diet and high fat diet are similar to wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Mahvash Disease		DOID:0112306	OMIM:619290	J:300368