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Lama2
Gene Detail
 Symbol
Name
ID
Lama2
laminin, alpha 2
MGI:99912
Synonyms mer, merosin, nmf417
Feature Type protein coding gene
Genetic Map
Chromosome 10
14.23 cM, cytoband A4-B1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr10:26980036-27619758 bp, - strand
From VEGA annotation of GRCm38

  639723 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37306  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lama2

Human
homologs
Human Homolog LAMA2, laminin, alpha 2
NCBI Gene ID 3908
neXtProt AC  NX_P24043
Human Synonyms  LAMM
Human Chr (Location)  6q22-q23; chr6:128883141-129516566 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LAMA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Spontaneous(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted and spontaneous mutations exhibit progressive growth retardation, ataxia, muscle atrophy and degeneration, infertility, and premature lethality. Muscle fiber degeneration is evident as early as the first week of life.
 
Human Diseases Modeled Using Mouse Lama2 (1)    Alleles Annotated to Human Diseases(7)    Phenotype Images(5)
Interactions
Lama2 interacts with 148 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process axon guidance, cell adhesion, ...
Component basal lamina, basement membrane, ...
Function receptor binding
External Resources: FuncBase
Expression
Literature Summary: (63 records)
Data Summary: Results (33)    Tissues (28)    Images (13)
Theiler Stages: 11, 19, 20, 21, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 23
Northern blot 5
RNase protection 5
cDNA source data(62)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(69) Genomic(4) cDNA(62) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000045038 (Evidence)
Ensembl Gene ModelENSMUSG00000019899 (Evidence)
Entrez Gene16773 (Evidence)
UniGene256087
DFCITC1581483, TC1607842, TC1620152, TC1624204, TC1705616
DoTSDT.530471, DT.55204925, DT.91585116, DT.97374564
NIA Mouse Gene IndexU031632
PDB1DYK, 1OKQ, 2WJS, 1QU0
Consensus CDS ProjectCCDS48526.1
International Mouse Knockout Project StatusLama2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045038 VEGA Gene Model | MGI Sequence Detail 639723 C57BL/6J ±  kb
transcript OTTMUST00000118352 VEGA | MGI Sequence Detail 9614 Not Applicable 
polypeptide OTTMUSP00000066069 VEGA | MGI Sequence Detail 3118 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(5)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(4649 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4663)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR002049 EGF-like, laminin
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR018031 Laminin B, subgroup
InterPro IPR000034 Laminin B type IV
InterPro IPR001791 Laminin G domain
InterPro IPR009254 Laminin I
InterPro IPR010307 Laminin II
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009651 laminin subunit alpha-2
References (Earliest) J:13125 Michelson AM, et al., Dystrophia muscularis: a hereditary primary myopathy in the house mouse. Proc Natl Acad Sci U S A. 1955 Dec 15;41(12):1079-1084
(Latest) J:208398 Korner Z, et al., Bortezomib Partially Improves Laminin alpha2 Chain-Deficient Muscular Dystrophy. Am J Pathol. 2014 May;184(5):1518-28
All references(260)
Disease annotation references (13)
Other
accession IDs
MGD-MRK-16710, MGD-MRK-9246

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory