Lama2
Gene Detail

Symbol Name ID

Lama2 laminin, alpha 2 MGI:99912

Synonyms

mer, merosin, nmf417

Feature Type

protein coding gene

Genetic Map

Chromosome 10

14.23 cM, cytoband A4-B1
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr10:26981288-27616942 bp, - strand From Ensembl annotation of GRCm38   635655 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37306  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Lama2

Human homologs

Human Homolog		LAMA2, laminin, alpha 2
NCBI Gene ID		3908
neXtProt AC		NX_P24043
Human Synonyms		LAMM
Human Chr (Location)		6q22-q23; chr6:128883141-129516566 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human LAMA2

Alleles and phenotypes

All alleles(7) : Targeted(2) Spontaneous(4) Chemically induced(1)
 

Homozygotes for targeted and spontaneous mutations exhibit progressive growth retardation, ataxia, muscle atrophy and degeneration, infertility, and premature lethality. Muscle fiber degeneration is evident as early as the first week of life.

 
Human Diseases Modeled Using Mouse Lama2 (1)    Alleles Annotated to Human Diseases(7)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	axon guidance, cell adhesion, ...
Component	basal lamina, basement membrane, ...
Function	receptor binding

External Resources: FuncBase

Expression

Literature Summary: (63 records)

Data Summary: Results (33)    Tissues (28)    Images (13)
Theiler Stages: 11, 19, 20, 21, 24, 26, 28

Assay Type	Results
Immunohistochemistry	23
Northern blot	5
RNase protection	5

cDNA source data(62)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(69) Genomic(4) cDNA(62) Primer pair(1) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000019899 (Evidence)
Entrez Gene	16773 (Evidence)
UniGene	256087
DFCI	TC1581483, TC1607842, TC1620152, TC1624204, TC1705616
DoTS	DT.530471, DT.55204925, DT.91585116, DT.97374564
NIA Mouse Gene Index	U031632
PDB	1DYK, 1OKQ, 2WJS, 1QU0
Consensus CDS Project	CCDS48526.1
International Mouse Knockout Project Status	Lama2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000019899	Ensembl Gene Model | MGI Sequence Detail	635655	C57BL/6J
transcript	ENSMUST00000092639	Ensembl | MGI Sequence Detail	9710	Not Applicable
polypeptide	ENSMUSP00000090304	Ensembl | MGI Sequence Detail	3118	Not Applicable

All sequences(38) RefSeq(4) UniProt(5)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(4629 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4643)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR008979	Galactose-binding domain-like
InterPro	IPR009030	Insulin-like growth factor binding protein, N-terminal
InterPro	IPR018031	Laminin B, subgroup
InterPro	IPR000034	Laminin B type IV
InterPro	IPR001791	Laminin G domain
InterPro	IPR009254	Laminin I
InterPro	IPR010307	Laminin II
InterPro	IPR008211	Laminin, N-terminal
Protein Ontology	PR:000009651	laminin subunit alpha-2

References

(Earliest) J:13125 Michelson AM, et al., Dystrophia muscularis: a hereditary primary myopathy in the house mouse. Proc Natl Acad Sci U S A. 1955 Dec 15;41(12):1079-1084
(Latest) J:206359 Gawlik KI, et al., Loss of Dystrophin and beta-Sarcoglycan Significantly Exacerbates the Phenotype of Laminin alpha2 Chain-Deficient Animals. Am J Pathol. 2014 Mar;184(3):740-52
All references(256)

Other accession IDs

MGD-MRK-16710, MGD-MRK-9246