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Lama2
Gene Detail
Symbol

Name
ID
Lama2
laminin, alpha 2
MGI:99912
Synonyms
mer, merosin, nmf417
Feature Type
protein coding gene
Genetic Map
Chromosome 10
14.23 cM, cytoband A4-B1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr10:26980036-27619758 bp, - strand
From VEGA annotation of GRCm38

  639723 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37306  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LAMA2
Gene Tree: Lama2

Human
homologs
LAMA2, laminin, alpha 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3908
neXtProt AC: NX_P24043

Human Synonyms: LAMM

Human Chr (Location): 6q22-q23; chr6:128883141-129516569 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LAMA2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Spontaneous(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted and spontaneous mutations exhibit progressive growth retardation, ataxia, muscle atrophy and degeneration, infertility, and premature lethality. Muscle fiber degeneration is evident as early as the first week of life.
 
Human Diseases Modeled in Mice Using Lama2 (1)    Mutations Annotated to Human Diseases (7)    Phenotype Images(5)
Interactions
Lama2 interacts with 147 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process axon guidance, cell adhesion, ...
Component basal lamina, basement membrane, ...
Function receptor binding
External Resources: FuncBase
Expression
Literature Summary: (64 records)
Data Summary: Results (36)    Tissues (31)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 26
Northern blot 5
RNase protection 5
cDNA source data(62)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase lama2 ; ZFIN lama2    NEW 
Molecular
reagents
All nucleic(69) Genomic(4) cDNA(62) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000045038 (Evidence)
Ensembl Gene Model ENSMUSG00000019899 (Evidence)
Entrez Gene 16773 (Evidence)
UniGene 256087
DFCI TC1581483, TC1607842, TC1620152, TC1624204, TC1705616
DoTS DT.530471, DT.55204925, DT.91585116, DT.97374564
NIA Mouse Gene Index U031632
PDB 1DYK, 1OKQ, 2WJS, 1QU0
Consensus CDS Project CCDS48526.1
International Mouse Phenotyping Consortium Status Lama2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045038 VEGA Gene Model | MGI Sequence Detail 639723 C57BL/6J ±  kb
transcript OTTMUST00000118352 VEGA | MGI Sequence Detail 9614 Not Applicable 
polypeptide OTTMUSP00000066069 VEGA | MGI Sequence Detail 3118 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(8) UniProt(6)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(4649 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4663)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR002049 EGF-like, laminin
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR018031 Laminin B, subgroup
InterPro IPR000034 Laminin B type IV
InterPro IPR001791 Laminin G domain
InterPro IPR009254 Laminin I
InterPro IPR010307 Laminin II
InterPro IPR008211 Laminin, N-terminal
Protein Ontology PR:000009651 laminin subunit alpha-2
References
(Earliest) J:13125 Michelson AM, et al., Dystrophia muscularis: a hereditary primary myopathy in the house mouse. Proc Natl Acad Sci U S A. 1955 Dec 15;41(12):1079-1084
(Latest) J:220875 Pedrotti S, et al., The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function. Hum Mol Genet. 2015 Apr 15;24(8):2360-74
All references(265)
Disease annotation references (13)
Other
accession IDs
MGD-MRK-16710, MGD-MRK-9246

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory