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Lama2 Gene Detail
Summary
  • Symbol
    Lama2
  • Name
    laminin, alpha 2
  • Synonyms
    mer, merosin, nmf417
  • Feature Type
    protein coding gene
  • IDs
    MGI:99912
    NCBI Gene: 16773
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:26981285-27617191 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 14.23 cM, cytoband A4-B1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4565 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99912
protein coding gene Chr10:26980036-27619758 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017105
protein coding gene Chr10:25087101-25753280 (-)
A/J MGP_AJ_G0017082
protein coding gene Chr10:24318149-24950044 (-)
AKR/J MGP_AKRJ_G0017042
protein coding gene Chr10:24735222-25386953 (-)
BALB/cJ MGP_BALBcJ_G0017045
protein coding gene Chr10:24437458-25070675 (-)
C3H/HeJ MGP_C3HHeJ_G0016865
protein coding gene Chr10:24942386-25612958 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017503
protein coding gene Chr10:25851031-26529419 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015201
protein coding gene Chr10:22940665-23546194 (-)
CAST/EiJ MGP_CASTEiJ_G0016444
protein coding gene Chr10:24950290-25624801 (-)
CBA/J MGP_CBAJ_G0016839
protein coding gene Chr10:27115553-27815651 (-)
DBA/2J MGP_DBA2J_G0016944
protein coding gene Chr10:24018445-24657102 (-)
FVB/NJ MGP_FVBNJ_G0016939
protein coding gene Chr10:23709941-24333567 (-)
LP/J MGP_LPJ_G0017021
protein coding gene Chr10:25071275-25738013 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016969
protein coding gene Chr10:27086980-27869837 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017539
protein coding gene Chr10:24602756-25266865 (-)
PWK/PhJ MGP_PWKPhJ_G0016226
protein coding gene Chr10:23840210-24477051 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016010
protein coding gene Chr10:24423387-25102050 (-)
WSB/EiJ MGP_WSBEiJ_G0016507
protein coding gene Chr10:24737499-25399488 (-)



Homology
more
  • Human Ortholog
    LAMA2, laminin subunit alpha 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LAMA2, laminin subunit alpha 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LAMM, MDC1A
  • Links
    NCBI Gene ID: 3908
    neXtProt AC: NX_P24043
    UniProt: P24043

  • Chr Location
    6q22.33; chr6:128883141-129516566 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37306
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LAMA2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Lama2 mouse models; 1 with human LAMA2 associations

Human Disease Mouse Models
      
IDs
View 10 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    8 with disease annotations
  • References
    11 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    85 phenotypes from 8 alleles in 19 genetic backgrounds
    27 phenotypes from multigenic genotypes
    5 images
    159 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted and spontaneous mutations exhibit progressive growth retardation, ataxia, muscle atrophy and degeneration, infertility, and premature lethality. Muscle fiber degeneration is evident as early as the first week of life.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16773 NCBI Gene Model | MGI Sequence Detail 635907 C57BL/6J ±  kb
    transcript NM_008481 RefSeq | MGI Sequence Detail 9734 C57BL/6  
    polypeptide Q60675 UniProt | EBI | MGI Sequence Detail 3118 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      Genomic 4
      cDNA 62
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16710, MGD-MRK-9246
    References
    more
    • Summaries
      All 295
      Developmental Gene Expression 72
      Diseases 11
      Gene Ontology 16
      Phenotypes 159
    • Earliest
      J:13125 Michelson AM, et al., Dystrophia muscularis: a hereditary primary myopathy in the house mouse. Proc Natl Acad Sci U S A. 1955 Dec 15;41(12):1079-1084
    • Latest
      J:264430 Pasteuning-Vuhman S, et al., Natural disease history of the dy2J mouse model of laminin alpha2 (merosin)-deficient congenital muscular dystrophy. PLoS One. 2018;13(5):e0197388

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory