Lama2
Gene Detail

Symbol

Name
ID

Lama2
laminin, alpha 2
MGI:99912

Synonyms

mer, merosin, nmf417

Feature Type

protein coding gene

Genetic Map

Chromosome 10
14.23 cM, cytoband A4-B1
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr10:26980036-27619758 bp, - strand From VEGA annotation of GRCm38   639723 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:37306  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lama2

Human
homologs

Human Homolog		LAMA2, laminin, alpha 2
NCBI Gene ID		3908
neXtProt AC		NX_P24043
Human Synonyms		LAMM
Human Chr (Location)		6q22-q23; chr6:128883141-129516566 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human LAMA2

Mutations,
alleles, and
phenotypes

All mutations/alleles(7) : Chemically induced (ENU)(1) Spontaneous(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for targeted and spontaneous mutations exhibit progressive growth retardation, ataxia, muscle atrophy and degeneration, infertility, and premature lethality. Muscle fiber degeneration is evident as early as the first week of life.

 
Human Diseases Modeled in Mice Using Lama2 (1)    Mutations Annotated to Human Diseases (7)    Phenotype Images(5)

Interactions

Lama2 interacts with 148 markers (Mir9-1, Mir9-2, Mir9-3, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (18 annotations)

Process	axon guidance, cell adhesion, ...
Component	basal lamina, basement membrane, ...
Function	receptor binding

External Resources: FuncBase

Expression

Literature Summary: (64 records)

Data Summary: Results (36)    Tissues (31)    Images (13)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	26
Northern blot	5
RNase protection	5

cDNA source data(62)
External Resources: GEO   Expression Atlas

Molecular
reagents

All nucleic(69) Genomic(4) cDNA(62) Primer pair(1) Other(2)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000045038 (Evidence)
Ensembl Gene Model	ENSMUSG00000019899 (Evidence)
Entrez Gene	16773 (Evidence)
UniGene	256087
DFCI	TC1581483, TC1607842, TC1620152, TC1624204, TC1705616
DoTS	DT.530471, DT.55204925, DT.91585116, DT.97374564
NIA Mouse Gene Index	U031632
PDB	1DYK, 1OKQ, 2WJS, 1QU0
Consensus CDS Project	CCDS48526.1
International Mouse Knockout Project Status	Lama2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000045038	VEGA Gene Model | MGI Sequence Detail	639723	C57BL/6J
transcript	OTTMUST00000118352	VEGA | MGI Sequence Detail	9614	Not Applicable
polypeptide	OTTMUSP00000066069	VEGA | MGI Sequence Detail	3118	Not Applicable

All sequences(60) RefSeq(4) UniProt(10)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(4649 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4663)

Protein-related
information

Resource	ID	Description
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR008979	Galactose-binding domain-like
InterPro	IPR009030	Insulin-like growth factor binding protein, N-terminal
InterPro	IPR018031	Laminin B, subgroup
InterPro	IPR000034	Laminin B type IV
InterPro	IPR001791	Laminin G domain
InterPro	IPR009254	Laminin I
InterPro	IPR010307	Laminin II
InterPro	IPR008211	Laminin, N-terminal
Protein Ontology	PR:000009651	laminin subunit alpha-2

References

(Earliest) J:13125 Michelson AM, et al., Dystrophia muscularis: a hereditary primary myopathy in the house mouse. Proc Natl Acad Sci U S A. 1955 Dec 15;41(12):1079-1084
(Latest) J:213615 Saito F, et al., Overexpression of LARGE suppresses muscle regeneration via down-regulation of insulin-like growth factor 1 and aggravates muscular dystrophy in mice. Hum Mol Genet. 2014 Sep 1;23(17):4543-58
All references(262)
Disease annotation references (13)

Other
accession IDs

MGD-MRK-16710, MGD-MRK-9246