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Spontaneous Allele Detail
Symbol: Lama2dy-Pas
Name: laminin, alpha 2; dystrophia muscularis Pasteur
MGI ID: MGI:6220701
Synonyms: dyPas
Gene: Lama2  Location: Chr10:26857281-27493021 bp, - strand  Genetic Position: Chr10, 14.23 cM, cytoband A4-B1
Alliance: Lama2dy-Pas page
Strain of Origin:  Non-inbred stock
Allele Type:    Spontaneous (Null/knockout)
Mutations:    Insertion, Viral insertion
Mutation detailsThis allele contains a 290 bp spontaneous insertion of the long terminal repeat of an intracisternal A-particle gene (IAP) and a 6.1 kb insertion of retrotransposon elements at nucleotide position 5113 (between exons 34 and 35). The translational reading frame is shifted from amino acid position 1706 and a stop codon appeared 12 codons later, producing a putative truncated protein devoid of domain I and II and the C-terminal G domain. (J:102806)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lama2 Mutation:  107 strains or lines available
First observed in 1994 at the animal facility of the Pasteur Institute in Paris (France) in animals derived from a non-inbred agouti background (J:102806).
Original:  J:102806 Besse S, et al., Spontaneous muscular dystrophy caused by a retrotransposal insertion in the mouse laminin alpha2 chain gene. Neuromuscul Disord. 2003 Mar;13(3):216-22
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory