Phenotypes Associated with This Genotype

Genotype
MGI:3848948

• Allelic Composition: Lama2^dy-8J/Lama2^dy-8J
• Genetic Background: C57BL/6J-Lama2^dy-8J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:149729 )

• homozygotes usually die by 3 to 4 weeks of age

behavior/neurological

hindlimb paralysis ( J:149729 )

• hind limb paralysis is first noticeable by approximately 2 weeks of age

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:149729 )

• in 2 homozygotes tested an increased ABR thresheld is found at the highest decibel intensity

muscle

myopathy ( J:149729 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital merosin-deficient muscular dystrophy 1A		DOID:0110636	OMIM:607855	J:149729