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Targeted Allele Detail
Symbol: Lama2tm1Stk
Name: laminin, alpha 2; targeted mutation 1, Shin'ichi Takeda
MGI ID: MGI:2153004
Synonyms: dy3K, dy3K, laminin211-
Gene: Lama2  Location: Chr10:26857281-27493021 bp, - strand  Genetic Position: Chr10, 14.23 cM, cytoband A4-B1
Alliance: Lama2tm1Stk page
Germline Transmission:  Earliest citation of germline transmission: J:43145
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into an exon that encodes a part of domain IV of the laminin 2 chain. Western blot analysis of lysates derived from homozygous mice demonstrated that the protein was not present. (J:43145)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 9 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lama2 Mutation:  107 strains or lines available
Original:  J:43145 Miyagoe Y, et al., Laminin alpha2 chain-null mutant mice by targeted disruption of the Lama2 gene: a new model of merosin (laminin 2)-deficient congenital muscular dystrophy. FEBS Lett. 1997 Sep 22;415(1):33-9
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory