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Chrna7 Gene Detail
Summary
  • Symbol
    Chrna7
  • Name
    cholinergic receptor, nicotinic, alpha polypeptide 7
  • Synonyms
    Acra7, alpha7, alpha7-nAChR, alpha7 nicotinic receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:99779
    NCBI Gene: 11441
  • Gene Overview
    MyGene.info: CHRNA7
Location & Maps
more
  • Sequence Map
    Chr7:63098692-63212569 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      113878 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 34.47 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CHRNA7, cholinergic receptor nicotinic alpha 7 subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHRNA7, cholinergic receptor nicotinic alpha 7 subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHRNA7-2, NACHRA7
  • Links
    NCBI Gene ID: 1139
    neXtProt AC: NX_P36544

  • Chr Location
    15q13.3; chr15:32030483-32172521 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 593
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CHRNA7
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Chrna7 mouse models; 1 with human CHRNA7 associations

Human Disease Mouse Models
       Schizophrenia 13; SCZD13   OMIM: 613025 View 1 model
       Chromosome 15q13.3 Deletion Syndrome   OMIM: 612001
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 4 alleles in 8 genetic backgrounds
    29 phenotypes from multigenic genotypes
    122 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    11
  • Genomic Mutations
    2 involving Chrna7
  • Incidental Mutations
Nullizygous mice lack hippocampal fast nicotinic currents but show nicotine-induced seizures as well as altered anxiety behavior, fertility defects, airway basal cell hyperplasia. and higher TNF sythesis when endotoxemic. Newborns homozygous for a knock-in allele die with increased neuron apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059577 VEGA Gene Model | MGI Sequence Detail 113878 C57BL/6J ±  kb
transcript OTTMUST00000146101 VEGA | MGI Sequence Detail 2078 Not Applicable  
polypeptide OTTMUSP00000076121 VEGA | MGI Sequence Detail 502 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1397 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
    IPR002394 Nicotinic acetylcholine receptor
Molecular
Reagents
less
  • All nucleic 21
    Genomic 1
    cDNA 18
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16565
References
more
  • Summaries
    All 187
    Developmental Gene Expression 14
    Diseases 1
    Gene Ontology 32
    Phenotypes 122
  • Earliest
    J:92450 Schultz JR, et al., Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice. J Biol Chem. 1992 Oct 25;267(30):21630-6
  • Latest
    J:234871 Srinivasan P, et al., Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Am J Physiol Gastrointest Liver Physiol. 2016 May 15;310(10):G874-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory