Sequence Detail

ID/Version

P49582 (UniProt | EBI)

Last sequence update: 1996-02-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Neuronal acetylcholine receptor subunit alpha-7; Short=nAChR7;AltName: Full=Nicotinic acetylcholine receptor subunit alpha-7;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 502 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	166	111	4	28

Sequence references in MGI

J:24219 Orr-Urtreger A, et al., Cloning and mapping of the mouse alpha 7-neuronal nicotinic acetylcholine receptor. Genomics. 1995 Mar 20;26(2):399-402
J:89610 Wang H, et al., Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature. 2003 Jan 23;421(6921):384-8
J:100458 de Jonge WJ, et al., Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol. 2005 Aug;6(8):844-51
J:300750 George AA, et al., Implications of Oligomeric Amyloid-Beta (oAbeta42) Signaling through alpha7beta2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline. J Neurosci. 2021 Jan 20;41(3):555-575
J:304156 Kweon HJ, et al., NACHO Engages N-Glycosylation ER Chaperone Pathways for alpha7 Nicotinic Receptor Assembly. Cell Rep. 2020 Aug 11;32(6):108025
J:359380 Tsoyi K, et al., Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction. Antioxid Redox Signal. 2011 Jun;14(11):2057-70
J:359791 Kim TH, et al., Stimulation of the alpha7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation. J Infect Dis. 2014 May 15;209(10):1668-77