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Sequence Detail
ID/Version
P49582 (UniProt | EBI) Last sequence update: 1996-02-01
Last annotation update: 2025-06-18
Sequence
description
from provider
RecName: Full=Neuronal acetylcholine receptor subunit alpha-7; Short=nAChR7;AltName: Full=Nicotinic acetylcholine receptor subunit alpha-7;Flags: Precursor;
Provider SWISS-PROT
Sequence
Polypeptide 502 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 166 111 4 28
Sequence references in MGI J:24219 Orr-Urtreger A, et al., Cloning and mapping of the mouse alpha 7-neuronal nicotinic acetylcholine receptor. Genomics. 1995 Mar 20;26(2):399-402
J:89610 Wang H, et al., Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature. 2003 Jan 23;421(6921):384-8
J:100458 de Jonge WJ, et al., Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol. 2005 Aug;6(8):844-51
J:300750 George AA, et al., Implications of Oligomeric Amyloid-Beta (oAbeta42) Signaling through alpha7beta2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline. J Neurosci. 2021 Jan 20;41(3):555-575
J:304156 Kweon HJ, et al., NACHO Engages N-Glycosylation ER Chaperone Pathways for alpha7 Nicotinic Receptor Assembly. Cell Rep. 2020 Aug 11;32(6):108025
J:359380 Tsoyi K, et al., Stimulation of alpha7 nicotinic acetylcholine receptor by nicotine attenuates inflammatory response in macrophages and improves survival in experimental model of sepsis through heme oxygenase-1 induction. Antioxid Redox Signal. 2011 Jun;14(11):2057-70
J:359791 Kim TH, et al., Stimulation of the alpha7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation. J Infect Dis. 2014 May 15;209(10):1668-77

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory