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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Chrna7
cholinergic receptor, nicotinic, alpha polypeptide 7
MGI:99779
44 phenotypes from 4 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Chrna7tm1.1Ehs/Chrna7tm1.1Ehs
involves: C57BL/6 * C57BL/6NTac 		no abnormal phenotype detected J:219327
Chrna7tm1.1Ehs/Chrna7tm1.1Ehs
Tg(Gfap-cre)77.6Mvs/0
B6.Cg-Chrna7tm1.1Ehs Tg(Gfap-cre)77.6Mvs 		no abnormal phenotype detected J:219327
Chrna7tm1b(EUCOMM)Hmgu/Chrna7tm1b(EUCOMM)Hmgu
C57BL/6N-Chrna7tm1b(EUCOMM)Hmgu/H 		abnormal bone structure J:211773
increased circulating cholesterol level J:211773
increased circulating HDL cholesterol level J:211773
Chrna7tm1Bay/Chrna7+
B6.129S7-Chrna7tm1Bay/J 		impaired olfaction J:166638
Chrna7tm1Bay/Chrna7+
involves: 129S7/SvEvBrd * C3H/HeN 		impaired olfaction J:166638
Chrna7tm1Bay/Chrna7tm1Bay
B6.129S7-Chrna7tm1Bay/J 		abnormal brain interneuron morphology J:214099
abnormal cerebral cortex morphology J:214099
abnormal cerebral cortex pyramidal cell morphology J:214099
abnormal GABA-mediated receptor currents J:214099
abnormal GABAergic neuron morphology J:214099
abnormal GABAergic neuron physiology J:214099
asthenozoospermia J:115434
decreased CNS synapse formation J:214099
decreased litter size J:92540
impaired olfaction J:166638
impaired spatial working memory J:123663
prolonged estrous cycle J:92540
reduced female fertility J:92540
normal reproductive system phenotype J:92540, J:115434
Chrna7tm1Bay/Chrna7tm1Bay
B6.Cg-Chrna7tm1Bay 		abnormal interleukin level J:89610
abnormal seizure response to pharmacological agent J:74703
abnormal spatial learning J:51149
abnormal tumor necrosis factor level J:89610
normal behavior/neurological phenotype J:51149
decreased anxiety-related response J:51149
Chrna7tm1Bay/Chrna7tm1Bay
involves: 129S7/SvEvBrd 		failure of neuromuscular synapse presynaptic differentiation J:161300
Chrna7tm1Bay/Chrna7tm1Bay
involves: 129S7/SvEvBrd * C3H/HeN 		impaired olfaction J:166638
Chrna7tm1Bay/Chrna7tm1Bay
involves: 129S7/SvEvBrd * C57BL/6 		abnormal airway basal cell differentiation J:154705
airway basal cell hyperplasia J:154705
decreased IgG level J:103908
decreased immunoglobulin level J:103908
normal immune system phenotype J:103908
Chrna7tm1Bay/Chrna7tm1Bay
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal brain morphology J:44288
abnormal myeloblast morphology/development J:140280
abnormal nicotine-mediated receptor currents J:44288
decreased erythroblast number J:140280
decreased neutrophil cell number J:140280
increased lymphocyte cell number J:140280
normal nervous system phenotype J:44288
reduced fertility J:44288
Chrna7tm2Bay/Chrna7tm2Bay
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal brain morphology J:61536
abnormal nicotine-mediated receptor currents J:61536
abnormal somatosensory cortex morphology J:61536
abnormal suckling behavior J:61536
decreased locomotor activity J:61536
increased neuron apoptosis J:61536
neonatal lethality, complete penetrance J:61536
tremors J:61536
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory