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Gcgr
Gene Detail
Symbol

Name
ID
Gcgr
glucagon receptor
MGI:99572
Synonyms
GR
Feature Type
protein coding gene
Genetic Map
Chromosome 11
84.24 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:120530699-120538986 bp, + strand
From VEGA annotation of GRCm38

  8288 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:131  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GCGR
Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Gcgr

Human
homologs
GCGR, glucagon receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2642
neXtProt AC: NX_P47871

Human Synonyms: GGR, GL-R

Human Chr (Location): 17q25; chr17:81804132-81814013 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GCGR

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a targeted mutation in this gene exhibit reduced blood glucose levels and increased plasma glucagon levels associated with alpha-cell hyperplasia.
 
Interactions
Gcgr interacts with 46 markers (Mir1b, Mir103-1, Mir135a-1, ...)
Expression
Literature Summary: (6 records)
Data Summary: Results (130)    Tissues (25)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 54
Northern blot 31
RT-PCR 45
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gcgr    NEW 
Molecular
reagents
All nucleic(29) Genomic(1) cDNA(26) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000004269 (Evidence)
Ensembl Gene Model ENSMUSG00000025127 (Evidence)
Entrez Gene 14527 (Evidence)
UniGene 22329
DFCI TC1583574, TC1616227
DoTS DT.101362834, DT.91337494, DT.94304436
NIA Mouse Gene Index U013665
Consensus CDS Project CCDS25739.1
International Mouse Phenotyping Consortium Status Gcgr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004269 VEGA Gene Model | MGI Sequence Detail 8288 C57BL/6J ±  kb
transcript OTTMUST00000009673 VEGA | MGI Sequence Detail 1957 Not Applicable 
polypeptide OTTMUSP00000004661 VEGA | MGI Sequence Detail 485 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR003290 GPCR, family 2, glucagon-like peptide-1/glucagon receptor
InterPro IPR003291 GPCR, family 2, glucagon receptor
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000007892 glucagon receptor
References
(Earliest) J:18259 Campos RV, et al., Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology. 1994 May;134(5):2156-64
(Latest) J:220981 Ali S, et al., Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction. Mol Metab. 2015 Feb;4(2):132-43
All references(72)
Other
accession IDs
MGD-MRK-16353

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory