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Gcgr
Gene Detail
Symbol

Name
ID
Gcgr
glucagon receptor
MGI:99572
Synonyms
GR
Feature Type
protein coding gene
Genetic Map
Chromosome 11
84.24 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:120530699-120538986 bp, + strand
From VEGA annotation of GRCm38

  8288 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:131  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Gcgr

Human
homologs
Human Homolog GCGR, glucagon receptor
NCBI Gene ID 2642
neXtProt AC  NX_P47871
Human Synonyms  GGR, GL-R
Human Chr (Location)  17q25; chr17:81804132-81814013 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GCGR
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a targeted mutation in this gene exhibit reduced blood glucose levels and increased plasma glucagon levels associated with alpha-cell hyperplasia.
 
Interactions
Gcgr interacts with 46 markers (Mir1b, Mir103-1, Mir135a-1, ...)
Expression
Literature Summary: (6 records)
Data Summary: Results (130)    Tissues (25)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 54
Northern blot 31
RT-PCR 45
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(1) cDNA(26) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000004269 (Evidence)
Ensembl Gene ModelENSMUSG00000025127 (Evidence)
Entrez Gene14527 (Evidence)
UniGene22329
DFCITC1583574, TC1616227
DoTSDT.101362834, DT.91337494, DT.94304436
NIA Mouse Gene IndexU013665
Consensus CDS ProjectCCDS25739.1
International Mouse Knockout Project StatusGcgr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004269 VEGA Gene Model | MGI Sequence Detail 8288 C57BL/6J ±  kb
transcript OTTMUST00000009673 VEGA | MGI Sequence Detail 1957 Not Applicable 
polypeptide OTTMUSP00000004661 VEGA | MGI Sequence Detail 485 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(14) UniProt(2)
Polymorphisms
SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR003290 GPCR, family 2, glucagon-like peptide-1/glucagon receptor
InterPro IPR003291 GPCR, family 2, glucagon receptor
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000007892 glucagon receptor
References
(Earliest) J:18259 Campos RV, et al., Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology. 1994 May;134(5):2156-64
(Latest) J:209046 Omar BA, et al., Fibroblast growth factor 21 (FGF21) and glucagon-like peptide 1 contribute to diabetes resistance in glucagon receptor-deficient mice. Diabetes. 2014 Jan;63(1):101-10
All references(68)
Other
accession IDs
MGD-MRK-16353

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory