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Gcgr Gene Detail
Summary
  • Symbol
    Gcgr
  • Name
    glucagon receptor
  • Synonyms
    GR
  • Feature Type
    protein coding gene
  • IDs
    MGI:99572
    NCBI Gene: 14527
  • Gene Overview
    MyGene.info: GCGR
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:120530699-120538986 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8288 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 84.24 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GCGR, glucagon receptor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GCGR, glucagon receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GGR, GL-R
  • Links
    NCBI Gene ID: 2642
    neXtProt AC: NX_P47871
    UniProt: P47871

  • Chr Location
    17q25.3; chr17:81804078-81814013 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human GCGR associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 4 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    3 images
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Animals homozygous for a targeted mutation in this gene exhibit reduced blood glucose levels and increased plasma glucagon and amino acid levels associated with alpha-cell hyperplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000004269 VEGA Gene Model | MGI Sequence Detail 8288 C57BL/6J ±  kb
    transcript OTTMUST00000009673 VEGA | MGI Sequence Detail 1957 Not Applicable  
    polypeptide OTTMUSP00000004661 VEGA | MGI Sequence Detail 485 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      18 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000007892 glucagon receptor
    • InterPro Domains
      IPR001879 GPCR, family 2, extracellular hormone receptor domain
      IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily
      IPR003290 GPCR, family 2, glucagon-like peptide-1/glucagon receptor
      IPR003291 GPCR, family 2, glucagon receptor
      IPR017981 GPCR, family 2-like
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 27
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16353
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 49
    • Earliest
      J:18259 Campos RV, et al., Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology. 1994 May;134(5):2156-64
    • Latest
      J:264582 Kim T, et al., Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21. Diabetes. 2018 Sep;67(9):1773-1782

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory