Mc4r
Gene Detail

Symbol Name ID

Mc4r melanocortin 4 receptor MGI:99457

Synonyms

Fatboy

Feature Type

protein coding gene

Genetic Map

Chromosome 18

39.72 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr18:66857715-66860472 bp, - strand From Ensembl annotation of GRCm38   2758 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4320  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: melanocortin receptor
Gene Tree: Mc4r

Human homologs

Human Homolog		MC4R, melanocortin 4 receptor
NCBI Gene ID		4160
neXtProt AC		NX_P32245
Human Chr (Location)		18q22; chr18:58038564-58040001 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MC4R

Alleles and phenotypes

All alleles(9) : Targeted(5) Chemically induced(4)
 

Mutations in this gene result in hyperglycemia and weight gain.

 
Human Diseases Modeled Using Mouse Mc4r (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	diet induced thermogenesis, energy reserve metabolic process, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, melanocortin receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (95)    Tissues (94)    Images (5)
Theiler Stages: 22

Assay Type	Results
RNA in situ	95

cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(7) Genomic(1) cDNA(5) Primer pair(1)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000047259 (Evidence)
Entrez Gene	17202 (Evidence)
UniGene	229447
DFCI	TC1588751
DoTS	DT.101356009
NIA Mouse Gene Index	U038510
Consensus CDS Project	CCDS29316.1
International Mouse Knockout Project Status	Mc4r

Sequences

Length	Strain/Species
genomic	ENSMUSG00000047259	Ensembl Gene Model | MGI Sequence Detail	2758	C57BL/6J
transcript	ENSMUST00000057942	Ensembl | MGI Sequence Detail	2758	Not Applicable
polypeptide	ENSMUSP00000054776	Ensembl | MGI Sequence Detail	332	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(26 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000155	Melanocortin 4 receptor
InterPro	IPR001671	Melanocortin/ACTH receptor
InterPro	IPR001908	Melanocortin receptor
Protein Ontology	PR:000001237	melanocortin receptor 4

References

(Earliest) J:12905 Gantz I, et al., Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J Biol Chem. 1993 Jul 15;268(20):15174-9
(Latest) J:195073 Arteaga-Solis E, et al., Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma. Cell Metab. 2013 Jan 8;17(1):35-48
All references(116)

Other accession IDs

MGD-MRK-16226, MGI:2671593