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Mc4r
Gene Detail
Symbol

Name
ID
Mc4r
melanocortin 4 receptor
MGI:99457
Synonyms
Fatboy
Feature Type
protein coding gene
Genetic Map
Chromosome 18
39.72 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:66857715-66860472 bp, - strand
From Ensembl annotation of GRCm38

  2758 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4320  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MC4R
Protein SuperFamily: melanocortin receptor
Gene Tree: Mc4r

Human
homologs
MC4R, melanocortin 4 receptor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4160
neXtProt AC: NX_P32245

Human Chr (Location): 18q22; chr18:60371331-60372768 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MC4R

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(5) Targeted(8)
Incidental mutations (data from APF )
 
Mutations in this gene result in hyperglycemia and weight gain.
 
Human Diseases Modeled in Mice Using Mc4r (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Mc4r interacts with 196 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process diet induced thermogenesis, energy reserve metabolic process, ...
Component cell, integral component of membrane, ...
Function G-protein coupled receptor activity, melanocortin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (95)    Tissues (94)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 95
cDNA source data(5)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase mc4r ; ZFIN mc4r    NEW 
Molecular
reagents
All nucleic(7) Genomic(1) cDNA(5) Primer pair(1)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000047259 (Evidence)
Entrez Gene 17202 (Evidence)
DFCI TC1588751
DoTS DT.101356009
NIA Mouse Gene Index U038510
Consensus CDS Project CCDS29316.1
International Mouse Phenotyping Consortium Status Mc4r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047259 Ensembl Gene Model | MGI Sequence Detail 2758 C57BL/6J ±  kb
transcript ENSMUST00000057942 Ensembl | MGI Sequence Detail 2758 Not Applicable 
polypeptide ENSMUSP00000054776 Ensembl | MGI Sequence Detail 332 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000155 Melanocortin 4 receptor
InterPro IPR001671 Melanocortin/ACTH receptor
InterPro IPR001908 Melanocortin receptor
Protein Ontology PR:000001237 melanocortin receptor 4
References
(Earliest) J:12905 Gantz I, et al., Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J Biol Chem. 1993 Jul 15;268(20):15174-9
(Latest) J:222852 Garfield AS, et al., A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci. 2015 Jun;18(6):863-71
All references(139)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-16226, MGI:2671593

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory