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Mc4r
Gene Detail
 Symbol
Name
ID
Mc4r
melanocortin 4 receptor
MGI:99457
Synonyms Fatboy
Feature Type protein coding gene
Genetic Map
Chromosome 18
39.72 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:66857715-66860472 bp, - strand
From Ensembl annotation of GRCm38

  2758 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4320  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: melanocortin receptor
Gene Tree: Mc4r

Human
homologs
Human Homolog MC4R, melanocortin 4 receptor
NCBI Gene ID 4160
neXtProt AC  NX_P32245
Human Chr (Location)  18q22; chr18:60371331-60372768 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MC4R
Alleles
and
phenotypes
All alleles(11) : Chemically induced (ENU)(4) Targeted(7)
Incidental mutations (data from APF )
 
Mutations in this gene result in hyperglycemia and weight gain.
 
Human Diseases Modeled Using Mouse Mc4r (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process diet induced thermogenesis, energy reserve metabolic process, ...
Component cell, integral component of membrane, ...
Function G-protein coupled receptor activity, melanocortin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (95)    Tissues (94)    Images (5)
Theiler Stages: 22
Assay TypeResults
RNA in situ 95
cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(7) Genomic(1) cDNA(5) Primer pair(1)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000047259 (Evidence)
Entrez Gene17202 (Evidence)
DFCITC1588751
DoTSDT.101356009
NIA Mouse Gene IndexU038510
Consensus CDS ProjectCCDS29316.1
International Mouse Knockout Project StatusMc4r
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047259 Ensembl Gene Model | MGI Sequence Detail 2758 C57BL/6J ±  kb
transcript ENSMUST00000057942 Ensembl | MGI Sequence Detail 2758 Not Applicable 
polypeptide ENSMUSP00000054776 Ensembl | MGI Sequence Detail 332 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR000155 Melanocortin 4 receptor
InterPro IPR001671 Melanocortin/ACTH receptor
InterPro IPR001908 Melanocortin receptor
Protein Ontology PR:000001237 melanocortin receptor 4
References (Earliest) J:12905 Gantz I, et al., Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J Biol Chem. 1993 Jul 15;268(20):15174-9
(Latest) J:203061 Gao Y, et al., Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia. 2014 Jan;62(1):17-25
All references(128)
Other
accession IDs
MGD-MRK-16226, MGI:2671593

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory