Nfe2l1
Gene Detail

Symbol Name ID

Nfe2l1 nuclear factor, erythroid derived 2,-like 1 MGI:99421

Synonyms

Lcrf1, LCR-F1, NRF1, TCF11, TCF-11

Feature Type

protein coding gene

Genetic Map

Chromosome 11

60.12 cM, cytoband D-E
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr11:96817431-96829955 bp, - strand From VEGA annotation of GRCm38   12525 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20685  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor TFC11
Gene Tree: Nfe2l1

Human homologs

Human Homolog		NFE2L1, nuclear factor (erythroid-derived 2)-like 1
NCBI Gene ID		4779
neXtProt AC		NX_Q14494
Human Synonyms		LCR-F1, NRF1, TCF11
Human Chr (Location)		17q21.3; chr17:46125686-46138907 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(21) : Targeted(7) Gene trapped(14)
 

Homozygotes for targeted null mutations fail to form a primitive streak, lack mesoderm, show a non-cell autonomous defect in definitive erythropoiesis, and die around embryonic day 7.5.

 
Human Diseases Modeled Using Mouse Nfe2l1 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	erythrocyte differentiation, positive regulation of transcription from RNA polymerase II promoter, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (183)    Tissues (99)    Images (25)
Theiler Stages: 2, 3, 4, 5, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 21, 23, 25, 28

Assay Type	Results
RNA in situ	115
RT-PCR	68

cDNA source data(258)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(267) Genomic(5) cDNA(258) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000001635 (Evidence)
Ensembl Gene Model	ENSMUSG00000038615 (Evidence)
Entrez Gene	18023 (Evidence)
UniGene	6743
DFCI	TC1573406, TC1634853, TC1651391, TC1675565, TC1683441, TC1685601, TC1746499
DoTS	DT.101127348, DT.101157780, DT.101253261, DT.110507664, DT.40153424, DT.484074, DT.91390701, DT.91420967, DT.94361985
NIA Mouse Gene Index	U033326, U300732
Consensus CDS Project	CCDS25304.1, CCDS48893.1, CCDS48894.1
International Mouse Knockout Project Status	Nfe2l1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001635	VEGA Gene Model | MGI Sequence Detail	12525	C57BL/6J
transcript	OTTMUST00000003218	VEGA | MGI Sequence Detail	2351	Not Applicable
polypeptide	OTTMUSP00000001555	VEGA | MGI Sequence Detail	742	Not Applicable

All sequences(127) RefSeq(12) UniProt(13)

Polymorphisms

RFLP(1) : SNPs(39 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR008917	Eukaryotic transcription factor, Skn-1-like, DNA-binding
Protein Ontology	PR:000011169	nuclear factor erythroid 2-related factor 1

References

(Earliest) J:23248 McKie J, et al., Cloning and mapping of murine Nfe2l1. Genomics. 1995 Feb 10;25(3):716-9
(Latest) J:192355 Kwong EK, et al., Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes. PLoS One. 2012;7(10):e48404
All references(58)

Other accession IDs

MGD-MRK-16184, MGI:2143987, MGI:2144512