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Nfe2l1
Gene Detail
 Symbol
Name
ID
Nfe2l1
nuclear factor, erythroid derived 2,-like 1
MGI:99421
Synonyms Lcrf1, LCR-F1, NRF1, TCF11, TCF-11
Feature Type protein coding gene
Genetic Map
Chromosome 11
60.12 cM, cytoband D-E
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:96817431-96829955 bp, - strand
From VEGA annotation of GRCm38

  12525 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20685  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor TFC11
Gene Tree: Nfe2l1

Human
homologs
Human Homolog NFE2L1, nuclear factor, erythroid 2-like 1
NCBI Gene ID 4779
neXtProt AC  NX_Q14494
Human Synonyms  LCR-F1, NRF1, TCF11
Human Chr (Location)  17q21.3; chr17:48048324-48061545 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(14) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations fail to form a primitive streak, lack mesoderm, show a non-cell autonomous defect in definitive erythropoiesis, and die around embryonic day 7.5.
 
Human Diseases Modeled Using Mouse Nfe2l1 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Nfe2l1 interacts with 272 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process erythrocyte differentiation, positive regulation of transcription from RNA polymerase II promoter, ...
Component cytoplasm, endoplasmic reticulum, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (175)    Tissues (94)    Images (25)
Theiler Stages: 2, 3, 4, 5, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 21, 23, 25, 27, 28
Assay TypeResults
RNA in situ 115
RT-PCR 60
cDNA source data(257)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(266) Genomic(5) cDNA(257) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000001635 (Evidence)
Ensembl Gene ModelENSMUSG00000038615 (Evidence)
Entrez Gene18023 (Evidence)
UniGene6743
DFCITC1573406, TC1634853, TC1651391, TC1675565, TC1683441, TC1685601, TC1746499
DoTSDT.101127348, DT.101157780, DT.101253261, DT.110507664, DT.40153424, DT.484074, DT.91390701, DT.91420967, DT.94361985
NIA Mouse Gene IndexU033326, U300732
Consensus CDS ProjectCCDS25304.1, CCDS48893.1, CCDS48894.1
International Mouse Knockout Project StatusNfe2l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001635 VEGA Gene Model | MGI Sequence Detail 12525 C57BL/6J ±  kb
transcript OTTMUST00000003218 VEGA | MGI Sequence Detail 2351 Not Applicable 
polypeptide OTTMUSP00000001555 VEGA | MGI Sequence Detail 742 Not Applicable 

For the selected sequences
All sequences(128) RefSeq(14) UniProt(12)
Polymorphisms RFLP(1) : SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
Protein Ontology PR:000011169 nuclear factor erythroid 2-related factor 1
References (Earliest) J:23248 McKie J, et al., Cloning and mapping of murine Nfe2l1. Genomics. 1995 Feb 10;25(3):716-9
(Latest) J:203246 Oh DH, et al., Deficiency in the nuclear-related factor erythroid 2 transcription factor (Nrf1) leads to genetic instability. FEBS J. 2012 Nov;279(22):4121-30
All references(60)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-16184, MGI:2143987, MGI:2144512

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory