Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; cholesterol binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including cell redox homeostasis; cellular response to cholesterol; and cholesterol homeostasis. Acts upstream of or within several processes, including cysteine transport; neurogenesis; and regulation of organelle organization. Located in endoplasmic reticulum membrane and nucleus. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early conceptus; female reproductive system; head mesenchyme; and urinary system. Used to study hepatocellular carcinoma. Orthologous to human NFE2L1 (NFE2 like bZIP transcription factor 1).