Fasl
Gene Detail

Symbol

Name
ID

Fasl
Fas ligand (TNF superfamily, member 6)
MGI:99255

Synonyms

APT1LG1, CD178, CD95L, Fasl, Fas-L, Tnfsf6

Feature Type

protein coding gene

Genetic Map

Chromosome 1
69.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)

Sequence Map

Chr1:161780689-161788495 bp, - strand From Ensembl annotation of GRCm38   7807 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tumor necrosis factor, TNF alpha type
Gene Tree: Fasl

Human
homologs

Human Homolog		FASLG, Fas ligand (TNF superfamily, member 6)
NCBI Gene ID		356
neXtProt AC		NX_P48023
Human Synonyms		ALPS1B, APT1LG1, APTL, CD178, CD95L, CD95-L, FASL, TNFSF6
Human Chr (Location)		1q23; chr1:172659045-172666873 (+)  GRCh38
Disease Associations		(2) Diseases Associated with Human FASLG

Mutations,
alleles, and
phenotypes

All mutations/alleles(15) : Chemically induced (ENU)(1) Spontaneous(2) Targeted(10) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a spontaneous allele, knock-out allele, or allele producting only the soluble isoform exhibit premature death due to the development of systemic lupus erythematosus, autoimmune glomerulonephritis, hepatomegaly, lymphadenopathy, and hypergammaglobulinaemia.

 
Human Diseases Modeled in Mice Using Fasl (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(1)

Interactions

Fasl interacts with 201 markers (Mir1b, Mir9-1, Mir9-2, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (45 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component	caveola, cytoplasmic membrane-bounded vesicle, ...
Function	cytokine activity, death receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)

Data Summary: Results (76)    Tissues (62)    Images (3)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	24
Western blot	6
RT-PCR	46

cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(38) Genomic(4) cDNA(31) Primer pair(3)
Microarray probesets(4)

Other database
links

Ensembl Gene Model	ENSMUSG00000000817 (Evidence)
Entrez Gene	14103 (Evidence)
UniGene	3355
DFCI	TC1583032
DoTS	DT.101360960, DT.40147693, DT.91446661, DT.91446662
NIA Mouse Gene Index	U021959
Consensus CDS Project	CCDS15418.1
International Mouse Knockout Project Status	Fasl

Sequences

Length	Strain/Species
genomic	ENSMUSG00000000817	Ensembl Gene Model | MGI Sequence Detail	7807	C57BL/6J
transcript	ENSMUST00000000834	Ensembl | MGI Sequence Detail	1937	Not Applicable
polypeptide	ENSMUSP00000000834	Ensembl | MGI Sequence Detail	279	Not Applicable

All sequences(40) RefSeq(8) UniProt(9)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(76 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR006052	Tumour necrosis factor
InterPro	IPR006053	Tumour necrosis factor alpha/beta/c
InterPro	IPR021184	Tumour necrosis factor, conserved site
InterPro	IPR008983	Tumour necrosis factor-like domain
Protein Ontology	PR:000000095	fas ligand, TNF-like

References

(Earliest) J:29572 Murphy ED, et al., Generalized lymphoproliferative disease (gld). Mouse News Lett. 1982;67:20-1
(Latest) J:215056 Sato A, et al., Involvement of the TNF and FasL produced by CD11b Kupffer cells/macrophages in CCl4-induced acute hepatic injury. PLoS One. 2014;9(3):e92515
All references(481)
Disease annotation references (2)

Other
accession IDs

MGD-MRK-10104, MGD-MRK-16013