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Fasl
Gene Detail
Symbol

Name
ID
Fasl
Fas ligand (TNF superfamily, member 6)
MGI:99255
Synonyms
APT1LG1, CD178, CD95L, Fasl, Fas-L, Tnfsf6
Feature Type
protein coding gene
Genetic Map
Chromosome 1
69.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr1:161780691-161788495 bp, - strand
From Ensembl annotation of GRCm38

  7805 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tumor necrosis factor, TNF alpha type
Gene Tree: Fasl

Human
homologs
Human Homolog FASLG, Fas ligand (TNF superfamily, member 6)
NCBI Gene ID 356
neXtProt AC  NX_P48023
Human Synonyms  ALPS1B, APT1LG1, APTL, CD178, CD95L, CD95-L, FASL, TNFSF6
Human Chr (Location)  1q23; chr1:172659045-172666873 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human FASLG
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(1) Spontaneous(2) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous allele, knock-out allele, or allele producting only the soluble isoform exhibit premature death due to the development of systemic lupus erythematosus, autoimmune glomerulonephritis, hepatomegaly, lymphadenopathy, and hypergammaglobulinaemia.
 
Human Diseases Modeled Using Mouse Fasl (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Fasl interacts with 201 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (16 records)
Data Summary: Results (76)    Tissues (62)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Western blot 6
RT-PCR 46
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(4) cDNA(31) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000000817 (Evidence)
Entrez Gene14103 (Evidence)
UniGene3355
DFCITC1583032
DoTSDT.101360960, DT.40147693, DT.91446661, DT.91446662
NIA Mouse Gene IndexU021959
Consensus CDS ProjectCCDS15418.1
International Mouse Knockout Project StatusFasl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000817 Ensembl Gene Model | MGI Sequence Detail 7805 C57BL/6J ±  kb
transcript ENSMUST00000000834 Ensembl | MGI Sequence Detail 1935 Not Applicable 
polypeptide ENSMUSP00000000834 Ensembl | MGI Sequence Detail 279 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(8) UniProt(9)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006052 Tumour necrosis factor
InterPro IPR006053 Tumour necrosis factor alpha/beta/c
InterPro IPR021184 Tumour necrosis factor, conserved site
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000000095 fas ligand, TNF-like
References
(Earliest) J:29572 Murphy ED, et al., Generalized lymphoproliferative disease (gld). Mouse News Lett. 1982;67:20-1
(Latest) J:211055 Weng D, et al., Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7391-6
All references(480)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10104, MGD-MRK-16013

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory