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Fasl Gene Detail
Summary
  • Symbol
    Fasl
  • Name
    Fas ligand (TNF superfamily, member 6)
  • Synonyms
    APT1LG1, CD178, CD95L, Fasl, Fas-L, Tnfsf6
  • Feature Type
    protein coding gene
  • IDs
    MGI:99255
    NCBI Gene: 14103
  • Gene Overview
    MyGene.info: FASLG
Location & Maps
more
  • Sequence Map
    Chr1:161780689-161788495 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7807 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FASLG, Fas ligand
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FASLG, Fas ligand
    Orthology source: HomoloGene
  • Synonyms
    ALPS1B, APT1LG1, APTL, CD178, CD95L, CD95-L, FASL, TNFSF6, TNLG1A
  • Links
    NCBI Gene ID: 356
    neXtProt AC: NX_P48023

  • Chr Location
    1q23; chr1:172659008-172666873 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Fasl mouse models; 2 with human FASLG associations

Human Disease Mouse Models
       Autoimmune Lymphoproliferative Syndrome; ALPS   OMIM: 601859 View 1 model
       Diabetes Mellitus, Insulin-Dependent; IDDM   OMIM: 222100 View 3 models
       Lung Cancer   OMIM: 211980
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    94 phenotypes from 12 alleles in 18 genetic backgrounds
    26 phenotypes from multigenic genotypes
    1 images
    350 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    2
  • Spontaneous
    2
  • Targeted
    10
  • Transgenic
    2
  • Genomic Mutations
    2 involving Fasl
  • Incidental Mutations
Mice homozygous for a spontaneous allele, knock-out allele, or allele producting only the soluble isoform exhibit premature death due to the development of systemic lupus erythematosus, autoimmune glomerulonephritis, hepatomegaly, lymphadenopathy, and hypergammaglobulinaemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050992 VEGA Gene Model | MGI Sequence Detail 7807 C57BL/6J ±  kb
transcript OTTMUST00000129297 VEGA | MGI Sequence Detail 1937 Not Applicable  
polypeptide OTTMUSP00000069474 VEGA | MGI Sequence Detail 279 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    159 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000000095 fas ligand, TNF-like
  • InterPro Domains
    IPR028326 Tumor necrosis factor ligand superfamily member 6
    IPR006053 Tumour necrosis factor
    IPR021184 Tumour necrosis factor, conserved site
    IPR006052 Tumour necrosis factor domain
    IPR008983 Tumour necrosis factor-like domain
Molecular
Reagents
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  • All nucleic 38
    Genomic 4
    cDNA 31
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10104, MGD-MRK-16013
References
more
  • Summaries
    All 486
    Developmental Gene Expression 16
    Diseases 6
    Gene Ontology 13
    Phenotypes 350
  • Earliest
    J:29572 Murphy ED, et al., Generalized lymphoproliferative disease (gld). Mouse News Lett. 1982;67:20-1
  • Latest
    J:227269 Shanker A, et al., Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity. Cancer Res. 2015 Dec 15;75(24):5260-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory