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Fasl
Gene Detail
 Symbol
Name
ID
Fasl
Fas ligand (TNF superfamily, member 6)
MGI:99255
Synonyms APT1LG1, CD178, CD95L, Fasl, Fas-L, Tnfsf6
Feature Type protein coding gene
Genetic Map
Chromosome 1
69.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr1:161780691-161788495 bp, - strand
From NCBI annotation of GRCm38

  7805 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tumor necrosis factor, TNF alpha type
Gene Tree: Fasl

Human
homologs
Human Homolog FASLG, Fas ligand (TNF superfamily, member 6)
NCBI Gene ID 356
neXtProt AC  NX_P48023
Human Synonyms  ALPS1B, APT1LG1, APTL, CD178, CD95L, CD95-L, FASL, TNFSF6
Human Chr (Location)  1q23; chr1:172659045-172666873 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human FASLG
Alleles
and
phenotypes
All alleles(12) : Targeted(10) Spontaneous(2)
 
Mice homozygous for a spontaneous allele, knock-out allele, or allele producting only the soluble isoform exhibit premature death due to the development of systemic lupus erythematosus, autoimmune glomerulonephritis, hepatomegaly, lymphadenopathy, and hypergammaglobulinaemia.
 
Human Diseases Modeled Using Mouse Fasl (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, apoptotic process, ...
Component caveola, cytoplasmic membrane-bounded vesicle, ...
Function cytokine activity, tumor necrosis factor receptor binding
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (76)    Tissues (62)    Images (3)
Theiler Stages: 23, 26, 28
Assay TypeResults
RNA in situ 24
Western blot 6
RT-PCR 46
cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(38) Genomic(4) cDNA(31) Primer pair(3)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000000817 (Evidence)
Entrez Gene14103 (Evidence)
UniGene3355
DFCITC1583032
DoTSDT.101360960, DT.40147693, DT.91446661, DT.91446662
NIA Mouse Gene IndexU021959
Consensus CDS ProjectCCDS15418.1
International Mouse Knockout Project StatusFasl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14103 NCBI Gene Model | MGI Sequence Detail 7805 C57BL/6J ±  kb
transcript NM_010177 RefSeq | MGI Sequence Detail 1935 C57BL/6 
polypeptide P41047 UniProt | EBI | MGI Sequence Detail 279 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(8) UniProt(5)
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006052 Tumour necrosis factor
InterPro IPR006053 Tumour necrosis factor alpha/beta/c
InterPro IPR021184 Tumour necrosis factor, conserved site
InterPro IPR008983 Tumour necrosis factor-like domain
Protein Ontology PR:000000095 fas ligand, TNF-like
Graphical View of Protein Domain Structure
References (Earliest) J:29572 Murphy ED, et al., Generalized lymphoproliferative disease (gld). Mouse News Lett. 1982;67:20-1
(Latest) J:205801 Bossaller L, et al., Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus. J Immunol. 2013 Sep 1;191(5):2104-14
All references(476)
Other
accession IDs
MGD-MRK-10104, MGD-MRK-16013

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory