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Fasl Gene Detail
Summary
  • Symbol
    Fasl
  • Name
    Fas ligand (TNF superfamily, member 6)
  • Synonyms
    APT1LG1, CD178, CD95L, Fasl, Fas-L, Tnfsf6
  • Feature Type
    protein coding gene
  • IDs
    MGI:99255
    NCBI Gene: 14103
  • Gene Overview
    MyGene.info: FASLG
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:161780691-161788495 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 69.95 cM
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99255
 protein coding gene Chr1:161780689-161788495 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016654
 protein coding gene Chr1:167088076-167097784 (-)
A/J MGP_AJ_G0016635
 protein coding gene Chr1:160282788-160290526 (-)
AKR/J MGP_AKRJ_G0016601
 protein coding gene Chr1:165153931-165162738 (-)
BALB/cJ MGP_BALBcJ_G0016596
 protein coding gene Chr1:160832168-160839958 (-)
C3H/HeJ MGP_C3HHeJ_G0016420
 protein coding gene Chr1:165358832-165366624 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017057
 protein coding gene Chr1:172729614-172739012 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014766
 protein coding gene Chr1:152373329-152381550 (-)
CAST/EiJ MGP_CASTEiJ_G0016000
 protein coding gene Chr1:164998721-165006559 (-)
CBA/J MGP_CBAJ_G0016395
 protein coding gene Chr1:178875628-178883309 (-)
DBA/2J MGP_DBA2J_G0016501
 protein coding gene Chr1:159248136-159255926 (-)
FVB/NJ MGP_FVBNJ_G0016499
 protein coding gene Chr1:157658775-157666517 (-)
LP/J MGP_LPJ_G0016572
 protein coding gene Chr1:168190357-168199136 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016524
 protein coding gene Chr1:186393177-186402524 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017093
 protein coding gene Chr1:165000390-165008182 (-)
PWK/PhJ MGP_PWKPhJ_G0015786
 protein coding gene Chr1:158424319-158432524 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015573
 protein coding gene Chr1:163876548-163884409 (-)
WSB/EiJ MGP_WSBEiJ_G0016062
 protein coding gene Chr1:165167659-165176016 (-)



Homology
more
  • Human Ortholog
    FASLG, Fas ligand
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FASLG, Fas ligand
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALPS1B, APT1LG1, APTL, CD178, CD95L, CD95-L, FASL, TNFSF6, TNLG1A
  • Links
    NCBI Gene ID: 356
    neXtProt AC: NX_P48023
    UniProt: P48023

  • Chr Location
    1q24.3; chr1:172659008-172666873 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with Fasl mouse models; 2 with human FASLG associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    94 phenotypes from 12 alleles in 18 genetic backgrounds
    26 phenotypes from multigenic genotypes
    1 images
    371 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele, knock-out allele, or allele producting only the soluble isoform exhibit premature death due to the development of systemic lupus erythematosus, autoimmune glomerulonephritis, hepatomegaly, lymphadenopathy, and hypergammaglobulinaemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    155
  • Tissues
    87
  • cDNA Data
    32
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14103 NCBI Gene Model | MGI Sequence Detail 7805 C57BL/6J ±  kb
    transcript NM_010177 RefSeq | MGI Sequence Detail 1935 C57BL/6  
    polypeptide P41047 UniProt | EBI | MGI Sequence Detail 279 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000000095 tumor necrosis factor ligand superfamily member 6
      (term hierarchy)
    • InterPro Domains
      IPR028326 Tumor necrosis factor ligand superfamily member 6
      IPR006053 Tumour necrosis factor
      IPR021184 Tumour necrosis factor, conserved site
      IPR006052 Tumour necrosis factor domain
      IPR008983 Tumour necrosis factor-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 4
      cDNA 32
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10104, MGD-MRK-16013
    References
    more
    • Summaries
      All 555
      Developmental Gene Expression 21
      Diseases 6
      Gene Ontology 15
      Phenotypes 371
    • Earliest
      J:7306 Roths JB, et al., A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice. J Exp Med. 1984 Jan 1;159(1):1-20
    • Latest
      J:272418 Meyer Zu Horste G, et al., Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1. Immunity. 2018 Mar 20;48(3):556-569.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    08/13/2019
    MGI 6.14     		The Jackson Laboratory