Fasl
Gene Detail

Symbol Name ID

Fasl Fas ligand (TNF superfamily, member 6) MGI:99255

Synonyms

APT1LG1, CD178, CD95L, Fas-L, Tnfsf6

Feature Type

protein coding gene

Genetic Map

Chromosome 1

69.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)

Sequence Map

Chr1:161780691-161788495 bp, - strand From NCBI annotation of GRCm38   7805 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tumor necrosis factor, TNF alpha type
Gene Tree: Fasl

Human homologs

Human Homolog		FASLG, Fas ligand (TNF superfamily, member 6)
NCBI Gene ID		356
neXtProt AC		NX_P48023
Human Synonyms		ALPS1B, APT1LG1, APTL, CD178, CD95L, CD95-L, FASL, TNFSF6
Human Chr (Location)		1q23; chr1:172628185-172636013 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FASLG

Alleles and phenotypes

All alleles(12) : Targeted(10) Spontaneous(2)
 

Mice homozygous for a spontaneous allele, knock-out allele, or allele producting only the soluble isoform exhibit premature death due to the development of systemic lupus erythematosus, autoimmune glomerulonephritis, hepatomegaly, lymphadenopathy, and hypergammaglobulinaemia.

 
Human Diseases Modeled Using Mouse Fasl (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of necroptosis by extracellular signals, ...
Component	caveola, cytoplasmic membrane-bounded vesicle, ...
Function	cytokine activity, tumor necrosis factor receptor binding

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (76)    Tissues (62)    Images (3)
Theiler Stages: 23, 26, 28

Assay Type	Results
RNA in situ	24
Western blot	6
RT-PCR	46

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) Genomic(4) cDNA(31) Primer pair(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000000817 (Evidence)
Entrez Gene	14103 (Evidence)
UniGene	3355
DFCI	TC1583032
DoTS	DT.101360960, DT.40147693, DT.91446661, DT.91446662
NIA Mouse Gene Index	U021959
Consensus CDS Project	CCDS15418.1
International Mouse Knockout Project Status	Fasl

Sequences

Length	Strain/Species
genomic	14103	NCBI Gene Model | MGI Sequence Detail	7805	C57BL/6J
transcript	NM_010177	RefSeq | MGI Sequence Detail	1935	C57BL/6
polypeptide	P41047	UniProt | EBI | MGI Sequence Detail	279	Not Applicable

All sequences(30) RefSeq(4) UniProt(5)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(40 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008064	Fas ligand
InterPro	IPR006052	Tumour necrosis factor
InterPro	IPR006053	Tumour necrosis factor alpha/beta/c
InterPro	IPR021184	Tumour necrosis factor, conserved site
InterPro	IPR008983	Tumour necrosis factor-like
Protein Ontology	PR:000000095	fas ligand, TNF-like

Graphical View of Protein Domain Structure

References

(Earliest) J:29572 Murphy ED, et al., Generalized lymphoproliferative disease (gld). Mouse News Lett. 1982;67:20-1
(Latest) J:193702 Hutchins NA, et al., Kupffer Cells Protect Liver Sinusoidal Endothelial Cells from Fas-Dependent Apoptosis in Sepsis by Down-Regulating gp130. Am J Pathol. 2013 Mar;182(3):742-54
All references(464)

Other accession IDs

MGD-MRK-10104, MGD-MRK-16013