Xpa
Gene Detail

Symbol Name ID

Xpa xeroderma pigmentosum, complementation group A MGI:99135

Synonyms

Xpac

Feature Type

protein coding gene

Genetic Map

Chromosome 4

24.49 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr4:46155347-46196311 bp, - strand From VEGA annotation of GRCm38   40965 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37298  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA excision repair protein XPAC
Gene Tree: Xpa

Human homologs

Human Homolog		XPA, xeroderma pigmentosum, complementation group A
NCBI Gene ID		7507
neXtProt AC		NX_P23025
Human Synonyms		XP1, XPAC
Human Chr (Location)		9q22.3; chr9:100437191-100459691 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human XPA

Alleles and phenotypes

All alleles(14) : Targeted(4) Gene trapped(10)
 

Homozygous null mutants are highly susceptible to tumors induced by UV (skin and ocular tumors), 7,12-dimethylbenz[a]anthracene (skin tumors), benzo[a]pyrene (pulmonary tumors), 4-nitroquinoline-1-oxide (tongue tumors) and aflatoxin B(1) (liver tumors).

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(10)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	DNA repair, intrinsic apoptotic signaling pathway in response to DNA damage, ...
Component	nucleus
Function	damaged DNA binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(40)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) Genomic(6) cDNA(40)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000006889 (Evidence)
Ensembl Gene Model	ENSMUSG00000028329 (Evidence)
Entrez Gene	22590 (Evidence)
UniGene	247036
DFCI	TC1585353, TC1592939, TC1595807, TC1647362, TC1656896
NIA Mouse Gene Index	U025028
Consensus CDS Project	CCDS18146.1
International Mouse Knockout Project Status	Xpa

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006889	VEGA Gene Model | MGI Sequence Detail	40965	C57BL/6J
transcript	OTTMUST00000015907	VEGA | MGI Sequence Detail	1241	Not Applicable
polypeptide	OTTMUSP00000007310	VEGA | MGI Sequence Detail	279	Not Applicable

All sequences(50) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(141 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009061	DNA binding domain, putative
InterPro	IPR000465	XPA
InterPro	IPR022658	XPA, conserved site
InterPro	IPR022656	XPA C- terminal
InterPro	IPR022652	Zinc finger, XPA-type, conserved site
Protein Ontology	PR:000017493	DNA repair protein complementing XP-A cells

References

(Earliest) J:6457 Lin PF, et al., Murine DNA repair gene located on chromosome 4. Nature. 1981 Jan 15;289(5794):191-4
(Latest) J:193520 Brun J, et al., Oncolytic Vaccinia virus safely and effectively treats skin tumors in mouse models of xeroderma pigmentosum. Int J Cancer. 2013 Feb 1;132(3):726-31
All references(144)

Other accession IDs

MGD-MRK-15829, MGD-MRK-15830, MGI:2140334