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Xpa
Gene Detail
Symbol

Name
ID
Xpa
xeroderma pigmentosum, complementation group A
MGI:99135
Synonyms
Xpac
Feature Type
protein coding gene
Genetic Map
Chromosome 4
24.49 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr4:46155347-46196311 bp, - strand
From VEGA annotation of GRCm38

  40965 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37298  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA excision repair protein XPAC
Gene Tree: Xpa

Human
homologs
Human Homolog XPA, xeroderma pigmentosum, complementation group A
NCBI Gene ID 7507
neXtProt AC  NX_P23025
Human Synonyms  XP1, XPAC
Human Chr (Location)  9q22.3; chr9:97634451-97697409 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human XPA
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(10) Targeted(4)
 
Homozygous null mutants are highly susceptible to tumors induced by UV (skin and ocular tumors), 7,12-dimethylbenz[a]anthracene (skin tumors), benzo[a]pyrene (pulmonary tumors), 4-nitroquinoline-1-oxide (tongue tumors) and aflatoxin B(1) (liver tumors).
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(10)
Interactions
Xpa interacts with 50 markers (Mir27b, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component cytoplasm, DNA replication factor A complex, ...
Function damaged DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) Genomic(6) cDNA(33)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000006889 (Evidence)
Ensembl Gene ModelENSMUSG00000028329 (Evidence)
Entrez Gene22590 (Evidence)
UniGene247036
DFCITC1585353, TC1592939, TC1595807, TC1647362, TC1656896
NIA Mouse Gene IndexU025028
Consensus CDS ProjectCCDS18146.1
International Mouse Knockout Project StatusXpa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006889 VEGA Gene Model | MGI Sequence Detail 40965 C57BL/6J ±  kb
transcript OTTMUST00000015907 VEGA | MGI Sequence Detail 1241 Not Applicable 
polypeptide OTTMUSP00000007310 VEGA | MGI Sequence Detail 279 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(3) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(270 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009061 DNA binding domain, putative
InterPro IPR000465 XPA
InterPro IPR022658 XPA, conserved site
InterPro IPR022656 XPA C- terminal
InterPro IPR022652 Zinc finger, XPA-type, conserved site
Protein Ontology PR:000017493 DNA repair protein complementing XP-A cells
References
(Earliest) J:6457 Lin PF, et al., Murine DNA repair gene located on chromosome 4. Nature. 1981 Jan 15;289(5794):191-4
(Latest) J:199551 Vaid M, et al., Silymarin inhibits ultraviolet radiation-induced immune suppression through DNA repair-dependent activation of dendritic cells and stimulation of effector T cells. Biochem Pharmacol. 2013 Apr 15;85(8):1066-76
All references(145)
Other
accession IDs
MGD-MRK-15829, MGD-MRK-15830, MGI:2140334

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory