About   Help   FAQ
Xpa Gene Detail
Summary
  • Symbol
    Xpa
  • Name
    xeroderma pigmentosum, complementation group A
  • Synonyms
    Xpac
  • Feature Type
    protein coding gene
  • IDs
    MGI:99135
    NCBI Gene: 22590
  • Gene Overview
    MyGene.info: XPA
Location & Maps
more
  • Sequence Map
    Chr4:46155347-46196311 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40965 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 24.49 cM, cytoband C2
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    XPA, XPA, DNA damage recognition and repair factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    XPA, XPA, DNA damage recognition and repair factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    XP1, XPAC
  • Links
    NCBI Gene ID: 7507
    neXtProt AC: NX_P23025

  • Chr Location
    9q22.33; chr9:97654398-97697409 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human XPA associations

Human Disease Mouse Models
       Xeroderma Pigmentosum, Complementation Group A; XPA   OMIM: 278700 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 3 alleles in 6 genetic backgrounds
    83 phenotypes from multigenic genotypes
    10 images
    98 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    10
  • Targeted
    4
Homozygous null mutants are highly susceptible to tumors induced by UV (skin and ocular tumors), 7,12-dimethylbenz[a]anthracene (skin tumors), benzo[a]pyrene (pulmonary tumors), 4-nitroquinoline-1-oxide (tongue tumors) and aflatoxin B(1) (liver tumors).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006889 VEGA Gene Model | MGI Sequence Detail 40965 C57BL/6J ±  kb
transcript OTTMUST00000015907 VEGA | MGI Sequence Detail 1241 Not Applicable  
polypeptide OTTMUSP00000007310 VEGA | MGI Sequence Detail 279 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    268 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    Genomic 6
    cDNA 33

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-15829, MGD-MRK-15830, MGI:2140334
References
more
  • Summaries
    All 147
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 12
    Phenotypes 98
  • Earliest
    J:6457 Lin PF, et al., Murine DNA repair gene located on chromosome 4. Nature. 1981 Jan 15;289(5794):191-4
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory