About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2386447
Allelic
Composition
Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh
Xpatm1Hvs/Xpatm1Hvs
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ercc2tm2(ERCC2)Jhjh mutation (0 available); any Ercc2 mutation (23 available)
Xpatm1Hvs mutation (4 available); any Xpa mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• surviving mice dead by 22 days of age

behavior/neurological

growth/size/body
• develop extreme cachexia by 2-3 weeks of age
• exhibit a retarded but steady growth until 1.5 weeks, but fail to gain weight after 2-3 weeks

skeleton

adipose tissue
• complete absence of body fat, including subcutaneous fat

cellular

integument
• severe dilation of hair follicles
• excessive epidermal hyperkeratosis


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory