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Tshr
Gene Detail
 Symbol
Name
ID
Tshr
thyroid stimulating hormone receptor
MGI:98849
Synonyms hypothroid, hyt, pet
Feature Type protein coding gene
Genetic Map
Chromosome 12
44.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr12:91400994-91540509 bp, + strand
From VEGA annotation of GRCm38

  139516 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:315  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glycoprotein hormone receptor
Gene Tree: Tshr

Human
homologs
Human Homolog TSHR, thyroid stimulating hormone receptor
NCBI Gene ID 7253
neXtProt AC  NX_P16473
Human Synonyms  CHNG1, hTSHR-I, LGR3
Human Chr (Location)  14q31; chr14:80954989-81146302 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human TSHR
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Spontaneous(3) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene exhibit profound hypothyroidism, developmental and growth retardation, impaired hearing with cochlear defects, and infertility. One mutation results in high postweaning mortality.
 
Human Diseases Modeled Using Mouse Tshr (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Tshr interacts with 234 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process adenylate cyclase-activating G-protein coupled receptor signaling pathway, adult locomotory behavior, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, protein-hormone receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (32)    Tissues (18)    Images (4)
Theiler Stages: 23, 26
Assay TypeResults
RNA in situ 28
RT-PCR 4
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) Genomic(5) cDNA(25) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000049745 (Evidence)
Ensembl Gene ModelENSMUSG00000020963 (Evidence)
Entrez Gene22095 (Evidence)
UniGene173847
DFCITC1583749, TC1591658, TC1697390
DoTSDT.522906, DT.523366, DT.91379830
NIA Mouse Gene IndexU014239
Consensus CDS ProjectCCDS26088.1, CCDS49135.1
International Mouse Knockout Project StatusTshr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049745 VEGA Gene Model | MGI Sequence Detail 139516 C57BL/6J ±  kb
transcript OTTMUST00000126709 VEGA | MGI Sequence Detail 4311 Not Applicable 
polypeptide OTTMUSP00000068492 VEGA | MGI Sequence Detail 764 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(6) UniProt(2)
Polymorphisms RFLP(4) : SNPs within 2kb(1065 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1191)
Protein-related
information
ResourceIDDescription
InterPro IPR002131 Glycoprotein hormone receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR026906 Leucine rich repeat 5
InterPro IPR002274 Thyrotropin receptor
Protein Ontology PR:000001677 thyrotropin receptor
References (Earliest) J:32749 Southard JL, et al., Petite (pet). Mouse News Lett. 1977;56:41
(Latest) J:203889 Endo T, et al., Excess TSH causes abnormal skeletal development in young mice with hypothyroidism via suppressive effects on the growth plate. Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E660-6
All references(99)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11041, MGD-MRK-13241, MGD-MRK-15275, MGI:2144847

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory