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Tshr
Gene Detail
Symbol

Name
ID
Tshr
thyroid stimulating hormone receptor
MGI:98849
Synonyms
hypothroid, hyt, pet
Feature Type
protein coding gene
Genetic Map
Chromosome 12
44.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr12:91400994-91540509 bp, + strand
From VEGA annotation of GRCm38

  139516 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:315  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TSHR
Protein SuperFamily: glycoprotein hormone receptor
Gene Tree: Tshr

Human
homologs
TSHR, thyroid stimulating hormone receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7253
neXtProt AC: NX_P16473

Human Synonyms: CHNG1, hTSHR-I, LGR3

Human Chr (Location): 14q31; chr14:80954989-81146302 (+)  GRCh38.p2

Disease Associations: (4) Diseases Associated with Human TSHR

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(1) Spontaneous(3) Targeted(1) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutations in this gene exhibit profound hypothyroidism, developmental and growth retardation, impaired hearing with cochlear defects, and infertility. One mutation results in high postweaning mortality.
 
Human Diseases Modeled in Mice Using Tshr (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Tshr interacts with 234 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (8 records)
Data Summary: Results (32)    Tissues (18)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
RT-PCR 4
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN tshr    NEW 
Molecular
reagents
All nucleic(31) Genomic(5) cDNA(25) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000049745 (Evidence)
Ensembl Gene Model ENSMUSG00000020963 (Evidence)
Entrez Gene 22095 (Evidence)
UniGene 173847
DFCI TC1583749, TC1591658, TC1697390
DoTS DT.522906, DT.523366, DT.91379830
NIA Mouse Gene Index U014239
Consensus CDS Project CCDS26088.1, CCDS49135.1
International Mouse Phenotyping Consortium Status Tshr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049745 VEGA Gene Model | MGI Sequence Detail 139516 C57BL/6J ±  kb
transcript OTTMUST00000126709 VEGA | MGI Sequence Detail 4311 Not Applicable 
polypeptide OTTMUSP00000068492 VEGA | MGI Sequence Detail 764 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(4) : SNPs within 2kb(1065 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1191)
Protein-related
information
ResourceIDDescription
InterPro IPR002131 Glycoprotein hormone receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR026906 Leucine rich repeat 5
InterPro IPR002274 Thyrotropin receptor
Protein Ontology PR:000001677 thyrotropin receptor
References
(Earliest) J:32749 Southard JL, et al., Petite (pet). Mouse News Lett. 1977;56:41
(Latest) J:222308 Fairfield H, et al., Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Genome Res. 2015 Jul;25(7):948-57
All references(103)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11041, MGD-MRK-13241, MGD-MRK-15275, MGI:2144847

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory