Tshr
Gene Detail

Symbol Name ID

Tshr thyroid stimulating hormone receptor MGI:98849

Synonyms

hypothroid, hyt, pet

Feature Type

protein coding gene

Genetic Map

Chromosome 12

44.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr12:91400993-91540509 bp, + strand From NCBI annotation of GRCm38   139517 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:315  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glycoprotein hormone receptor
Gene Tree: Tshr

Human homologs

Human Homolog		TSHR, thyroid stimulating hormone receptor
NCBI Gene ID		7253
neXtProt AC		NX_P16473
Human Synonyms		CHNG1, hTSHR-I, LGR3
Human Chr (Location)		14q31; chr14:81421869-81612646 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human TSHR

Alleles and phenotypes

All alleles(2) : Targeted(1) Spontaneous(1)
 

Mutations in this gene exhibit profound hypothyroidism, developmental and growth retardation, impaired hearing with cochlear defects, and infertility. One mutation results in high postweaning mortality.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	adenylate cyclase-activating G-protein coupled receptor signaling pathway, adult locomotory behavior, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, protein-hormone receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (32)    Tissues (18)    Images (4)
Theiler Stages: 23, 26

Assay Type	Results
RNA in situ	28
RT-PCR	4

cDNA source data(23)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) Genomic(5) cDNA(25) Primer pair(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000020963 (Evidence)
Entrez Gene	22095 (Evidence)
UniGene	173847
DFCI	TC1583749, TC1591658, TC1697390
DoTS	DT.522906, DT.523366, DT.91379830
NIA Mouse Gene Index	U014239
Consensus CDS Project	CCDS26088.1, CCDS49135.1
International Mouse Knockout Project Status	Tshr

Sequences

Length	Strain/Species
genomic	22095	NCBI Gene Model | MGI Sequence Detail	139517	C57BL/6J
transcript	NM_011648	RefSeq | MGI Sequence Detail	4332	C57BL/6
polypeptide	P47750	UniProt | EBI | MGI Sequence Detail	764	Not Applicable

All sequences(32) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(4) : SNPs within 2kb(1065 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1191)

Protein-related information

Resource	ID	Description
InterPro	IPR002131	Glycoprotein hormone receptor
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR026906	Leucine rich repeat 5
InterPro	IPR002274	Thyrotropin receptor
Protein Ontology	PR:000001677	thyrotropin receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:32749 Southard, et al., Petite (pet). Mouse News Lett. 1977;56:41
(Latest) J:192466 Baliram R, et al., Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling. J Clin Invest. 2012 Oct 1;122(10):3737-41
All references(92)

Other accession IDs

MGD-MRK-11041, MGD-MRK-13241, MGD-MRK-15275, MGI:2144847