Automated description from the Alliance of Genome Resources (Release 6.0.0)
Enables thyroid-stimulating hormone receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including adult locomotory behavior; dopaminergic neuron differentiation; and inner ear development. Located in plasma membrane. Is expressed in bladder; renal vasculature; thyroid gland; and thyroid gland lobe. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in Graves ophthalmopathy; Graves' disease; cardiomyopathy; mitral valve prolapse; and nonautoimmune hyperthyroidism. Orthologous to human TSHR (thyroid stimulating hormone receptor).