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Tshrhyt
Spontaneous Allele Detail
Summary
Symbol: Tshrhyt
Name: thyroid stimulating hormone receptor; hypothyroid
MGI ID: MGI:1856914
Synonyms: hyt, pet, petite
Gene: Tshr  Location: Chr12:91367767-91507283 bp, + strand  Genetic Position: Chr12, 44.51 cM
Alliance: Tshrhyt page
Mutation
origin
Strain of Origin:  RF/J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsThe mutation in the hypothyroid mouse is a C-to-T transition at coding nucleotide 1667. This results in a substitution of proline with leucine at position 556 (p.P556L) in transmembrane domain IV of the encoded protein. (J:16854, J:26725)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 14 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tshr Mutation:  7 strains or lines available
References
Original:  J:32749 Southard JL, et al., Petite (pet). Mouse News Lett. 1977;56:41
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory