Tfrc
Gene Detail

Symbol Name ID

Tfrc transferrin receptor MGI:98822

Synonyms

2610028K12Rik, CD71, E430033M20Rik, Mtvr1, Mtvr-1, p90, TfR1, Trfr

Feature Type

protein coding gene

Genetic Map

Chromosome 16

23.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr16:32608920-32632794 bp, + strand From VEGA annotation of GRCm38   23875 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2429  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: transferrin receptor
Gene Tree: Tfrc

Human homologs

Human Homolog		TFRC, transferrin receptor (p90, CD71)
NCBI Gene ID		7037
neXtProt AC		NX_P02786
Human Synonyms		CD71, p90, T9, TFR, TFR1, TR, TRFR
Human Chr (Location)		3q29; chr3:195776155-195809032 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(56) : Targeted(2) Gene trapped(53) Chemically induced(1)
 

Homozygous mutant embryos do not survive past E12.5, exhibiting anemia, hydrops fetalis, and neurological defects. Haploinsufficiency results in abnromal erythrocytes and tissue iron deficiency.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	cellular iron ion homeostasis, endocytosis, ...
Component	cell surface, coated pit, ...
Function	chaperone binding, Hsp70 protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (189)    Tissues (33)    Images (29)
Theiler Stages: 15, 23, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	165
Western blot	16
RT-PCR	4

cDNA source data(310)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(313) cDNA(310) Primer pair(2) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000026922 (Evidence)
Ensembl Gene Model	ENSMUSG00000022797 (Evidence)
Entrez Gene	22042 (Evidence)
UniGene	28683
DFCI	TC1573444, TC1595942, TC1697447
DoTS	DT.101404802, DT.101709706, DT.110723831, DT.533894
NIA Mouse Gene Index	U017025
Consensus CDS Project	CCDS28123.1
International Mouse Knockout Project Status	Tfrc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026922	VEGA Gene Model | MGI Sequence Detail	23875	C57BL/6J
transcript	OTTMUST00000066569	VEGA | MGI Sequence Detail	4890	Not Applicable
polypeptide	OTTMUSP00000033381	VEGA | MGI Sequence Detail	763	Not Applicable

All sequences(58) RefSeq(2) UniProt(5)

Polymorphisms

PCR(1) : SNPs(83 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007484	Peptidase M28
InterPro	IPR003137	Protease-associated domain, PA
InterPro	IPR007365	Transferrin receptor-like, dimerisation domain
Protein Ontology	PR:000001945	transferrin receptor protein 1

References

(Earliest) J:30966 Trowbridge IS, et al., Murine cell surface transferrin receptor: studies with an anti-receptor monoclonal antibody. J Cell Physiol. 1982 Sep;112(3):403-10
(Latest) J:191676 Manceau V, et al., The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS One. 2012;7(8):e43946
All references(101)

Other accession IDs

MGD-MRK-12700, MGD-MRK-12701, MGD-MRK-15225, MGI:1923611, MGI:2146387, MGI:2146425, MGI:2146541, MGI:2442494, MGI:97229