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Tfrc
Gene Detail
 Symbol
Name
ID
Tfrc
transferrin receptor
MGI:98822
Synonyms 2610028K12Rik, CD71, E430033M20Rik, Mtvr1, Mtvr-1, p90, TfR1, Trfr
Feature Type protein coding gene
Genetic Map
Chromosome 16
23.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr16:32608920-32632794 bp, + strand
From VEGA annotation of GRCm38

  23875 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2429  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: transferrin receptor
Gene Tree: Tfrc

Human
homologs
Human Homolog TFRC, transferrin receptor
NCBI Gene ID 7037
neXtProt AC  NX_P02786
Human Synonyms  CD71, p90, T9, TFR, TFR1, TR, TRFR
Human Chr (Location)  3q29; chr3:196049284-196082161 (-)  GRCh38
Alleles
and
phenotypes
All alleles(56) : Chemically induced (ENU)(1) Gene trapped(53) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant embryos do not survive past E12.5, exhibiting anemia, hydrops fetalis, and neurological defects. Haploinsufficiency results in abnromal erythrocytes and tissue iron deficiency.
 
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process cellular iron ion homeostasis, endocytosis, ...
Component blood microparticle, cell surface, ...
Function chaperone binding, double-stranded RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (199)    Tissues (38)    Images (33)
Theiler Stages: 15, 23, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 174
Western blot 16
RT-PCR 4
cDNA source data(309)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(313) cDNA(310) Primer pair(2) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000026922 (Evidence)
Ensembl Gene ModelENSMUSG00000022797 (Evidence)
Entrez Gene22042 (Evidence)
UniGene28683
DFCITC1573444, TC1595942, TC1697447
DoTSDT.101404802, DT.101709706, DT.110723831, DT.533894
NIA Mouse Gene IndexU017025
Consensus CDS ProjectCCDS28123.1
International Mouse Knockout Project StatusTfrc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026922 VEGA Gene Model | MGI Sequence Detail 23875 C57BL/6J ±  kb
transcript OTTMUST00000066569 VEGA | MGI Sequence Detail 4890 Not Applicable 
polypeptide OTTMUSP00000033381 VEGA | MGI Sequence Detail 763 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(4) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(91 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007484 Peptidase M28
InterPro IPR003137 Protease-associated domain, PA
InterPro IPR007365 Transferrin receptor-like, dimerisation domain
Protein Ontology PR:000001945 transferrin receptor protein 1
References (Earliest) J:30966 Trowbridge IS, et al., Murine cell surface transferrin receptor: studies with an anti-receptor monoclonal antibody. J Cell Physiol. 1982 Sep;112(3):403-10
(Latest) J:198162 Chen C, et al., Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab. 2013 Mar 5;17(3):343-52
All references(107)
Other
accession IDs
MGD-MRK-12700, MGD-MRK-12701, MGD-MRK-15225, MGI:1923611, MGI:2146387, MGI:2146425, MGI:2146541, MGI:2442494, MGI:97229

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory