Automated description from the Alliance of Genome Resources (Release 6.0.0)
Predicted to enable several functions, including Hsp70 protein binding activity; protein homodimerization activity; and transferrin receptor activity. Involved in osteoclast differentiation; positive regulation of bone resorption; and positive regulation of lymphocyte proliferation. Acts upstream of or within cellular response to leukemia inhibitory factor and intracellular iron ion homeostasis. Located in several cellular components, including clathrin-coated pit; endosome; and extracellular exosome. Part of HFE-transferrin receptor complex. Is expressed in several structures, including extraembryonic component; gut; liver; lung; and meninges. Used to study Weissenbacher-Zweymuller syndrome. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor).