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Tph1
Gene Detail
 Symbol
Name
ID
Tph1
tryptophan hydroxylase 1
MGI:98796
Feature Type protein coding gene
Genetic Map
Chromosome 7
30.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr7:46647130-46672537 bp, - strand
From VEGA annotation of GRCm38

  25408 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121565  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: tyrosine 3-monooxygenase
Gene Tree: Tph1

Human
homologs
Human Homolog TPH1, tryptophan hydroxylase 1
NCBI Gene ID 7166
neXtProt AC  NX_P17752
Human Synonyms  TPRH, TRPH
Human Chr (Location)  11p15.3-p14; chr11:18020537-18040788 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null allele display no gross behavioral abnormalities. Mice homozygous for a second null allele display fatigue, breathing difficulties, progressive pallor, and impaired cardiac function.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process aromatic amino acid family metabolic process, bone remodeling, ...
Component neuron projection
Function amino acid binding, iron ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (49)    Tissues (44)    Images (13)
Theiler Stages: 2, 3, 4, 19, 22, 23, 24, 28
Assay TypeResults
RNA in situ 41
RT-PCR 8
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(26) Genomic(12) cDNA(13) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000036091 (Evidence)
Ensembl Gene ModelENSMUSG00000040046 (Evidence)
Entrez Gene21990 (Evidence)
DFCITC1581593, TC1668618, TC1699840
DoTSDT.101161412, DT.101344434, DT.102555260, DT.492697, DT.55136412
NIA Mouse Gene IndexU028556, U188014
EC1.14.16.4
Consensus CDS ProjectCCDS21280.1, CCDS71970.1
International Mouse Knockout Project StatusTph1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036091 VEGA Gene Model | MGI Sequence Detail 25408 C57BL/6J ±  kb
transcript OTTMUST00000092725 VEGA | MGI Sequence Detail 1762 Not Applicable 
polypeptide OTTMUSP00000051314 VEGA | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(8) UniProt(6)
Polymorphisms RFLP(2) : SNPs within 2kb(278 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002912 ACT domain
InterPro IPR001273 Aromatic amino acid hydroxylase
InterPro IPR019774 Aromatic amino acid hydroxylase, C-terminal
InterPro IPR018301 Aromatic amino acid hydroxylase, iron/copper binding site
InterPro IPR005963 Tryptophan 5-monooxygenase
InterPro IPR019773 Tyrosine 3-monooxygenase-like
Protein Ontology PR:000016575 tryptophan 5-hydroxylase 1
References (Earliest) J:4454 Kulikov AV, et al., [Genetic control of tryptophan hydroxylase activity in the mouse brain]. Genetika. 1983 May;19(5):784-8
(Latest) J:209858 Amireault P, et al., Serotonin is a key factor for mouse red blood cell survival. PLoS One. 2013;8(12):e83010
All references(99)
Other
accession IDs
MGD-MRK-15178

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory