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Spp1 Gene Detail
Summary
  • Symbol
    Spp1
  • Name
    secreted phosphoprotein 1
  • Synonyms
    2ar, 44kDa bone phosphoprotein, Apl-1, BNSP, bone sialoprotein 1, ETA-1, minopontin, OP, Opn, Opnl, osteopontin, osteopontin-like protein, Ric, Spp-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98389
    NCBI Gene: 20750
  • Gene Overview
    MyGene.info: SPP1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:104435118-104441050 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5933 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 50.68 cM
  • Mapping Data
    35 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    SPP1, secreted phosphoprotein 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SPP1, secreted phosphoprotein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BNSP, BSPI, ETA-1, OPN
  • Links
    NCBI Gene ID: 6696
    neXtProt AC: NX_P10451
    UniProt: P10451

  • Chr Location
    4q22.1; chr4:87975650-87983411 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    99 phenotypes from 5 alleles in 27 genetic backgrounds
    47 phenotypes from multigenic genotypes
    2 images
    188 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Two alleles determine natural resistance/susceptibility to the lethal effects of the Gilliam strain of Rickettsia tsutsugamushi. Mice homozygous for a knock-out allele exhibit abnormal osteoclast physiology, macrophage recruitment, wound healing, response to injury, and inflammatory response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000024389 VEGA Gene Model | MGI Sequence Detail 5933 C57BL/6J ±  kb
    transcript OTTMUST00000059774 VEGA | MGI Sequence Detail 1411 Not Applicable  
    polypeptide OTTMUSP00000029096 VEGA | MGI Sequence Detail 295 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      149 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 1302
      Genomic 2
      cDNA 1281
      Primer pair 9
      Other 10

      Microarray probesets 3
    Other
    Accession IDs
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    MGD-MRK-13036, MGD-MRK-13037, MGD-MRK-1359, MGD-MRK-13878, MGD-MRK-14544, MGD-MRK-14545, MGD-MRK-9656, MGI:2140792, MGI:2140963
    References
    more
    • Summaries
      All 541
      Developmental Gene Expression 198
      Gene Ontology 12
      Phenotypes 188
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:257556 Foster BL, et al., Osteopontin regulates dentin and alveolar bone development and mineralization. Bone. 2018 Feb;107(None):196-207

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/05/2018
    MGI 6.12
    The Jackson Laboratory