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Spp1
Gene Detail
Symbol

Name
ID
Spp1
secreted phosphoprotein 1
MGI:98389
STS
Synonyms
2ar, 44kDa bone phosphoprotein, Apl-1, BNSP, bone sialoprotein 1, ETA-1, minopontin, OP, Opn, Opnl, osteopontin, osteopontin-like protein, Ric, Spp-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
50.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(34)
Sequence Map
Chr5:104435118-104441050 bp, + strand
From VEGA annotation of GRCm38

  5933 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20156  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: osteopontin
Gene Tree: Spp1

Human
homologs
Human Homolog SPP1, secreted phosphoprotein 1
NCBI Gene ID 6696
neXtProt AC  NX_P10451
Human Synonyms  BNSP, BSPI, ETA-1, OPN
Human Chr (Location)  4q22.1; chr4:87975650-87983411 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(29) Spontaneous(2) Targeted(4)
 
Two alleles determine natural resistance/susceptibility to the lethal effects of the Gilliam strain of Rickettsia tsutsugamushi. Mice homozygous for a knock-out allele exhibit abnormal osteoclast physiology, macrophage recruitment, wound healing, response to injury, and inflammatory response.
 
Interactions
Spp1 interacts with 118 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process biomineral tissue development, cell adhesion, ...
Component apical part of cell, cell projection, ...
Function cytokine activity, extracellular matrix binding
External Resources: FuncBase
Expression
Literature Summary: (167 records)
Data Summary: Results (494)    Tissues (241)    Images (108)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 36
RNA in situ 346
Northern blot 45
RT-PCR 67
cDNA source data(1276)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(1301) Genomic(2) cDNA(1281) Primer pair(9) Other(9)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024389 (Evidence)
Ensembl Gene ModelENSMUSG00000029304 (Evidence)
Entrez Gene20750 (Evidence)
UniGene288474
DFCITC1573661
DoTSDT.101741470, DT.110654906, DT.91311983, DT.94153233, DT.94153236, DT.94153266, DT.97332913
NIA Mouse Gene IndexU005895
Consensus CDS ProjectCCDS19486.1, CCDS57367.1
International Mouse Knockout Project StatusSpp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024389 VEGA Gene Model | MGI Sequence Detail 5933 C57BL/6J ±  kb
transcript OTTMUST00000059774 VEGA | MGI Sequence Detail 1411 Not Applicable 
polypeptide OTTMUSP00000029096 VEGA | MGI Sequence Detail 295 Not Applicable 

For the selected sequences
All sequences(107) RefSeq(10) UniProt(21)
Polymorphisms
RFLP(4) : SNPs within 2kb(156 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002038 Osteopontin
InterPro IPR019841 Osteopontin, conserved site
Protein Ontology PR:000015561 osteopontin
References
(Earliest) J:5949 Groves MG, et al., Host defenses in experimental scrub typhus: genetics of natural resistance to infection. Infect Immun. 1978 Feb;19(2):583-8
(Latest) J:213351 Wong TM, et al., Respiratory syncytial virus (RSV) infection in elderly mice results in altered antiviral gene expression and enhanced pathology. PLoS One. 2014;9(2):e88764
All references(421)
Other
accession IDs
MGD-MRK-13036, MGD-MRK-13037, MGD-MRK-1359, MGD-MRK-13878, MGD-MRK-14544, MGD-MRK-14545, MGD-MRK-9656, MGI:2140792, MGI:2140963

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory