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Spp1 Gene Detail
Summary
  • Symbol
    Spp1
  • Name
    secreted phosphoprotein 1
  • Synonyms
    2ar, 44kDa bone phosphoprotein, Apl-1, BNSP, bone sialoprotein 1, ETA-1, minopontin, OP, Opn, Opnl, osteopontin, osteopontin-like protein, Ric, Spp-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98389
    NCBI Gene: 20750
  • Gene Overview
    MyGene.info: SPP1
Location & Maps
more
  • Sequence Map
    Chr5:104435118-104441050 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5933 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SPP1, secreted phosphoprotein 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SPP1, secreted phosphoprotein 1
    Orthology source: HomoloGene
  • Synonyms
    BNSP, BSPI, ETA-1, OPN
  • Links
    NCBI Gene ID: 6696
    neXtProt AC: NX_P10451

  • Chr Location
    4q22.1; chr4:87975650-87983411 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    97 phenotypes from 4 alleles in 26 genetic backgrounds
    45 phenotypes from multigenic genotypes
    2 images
    169 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Gene trapped
    21
  • Radiation induced
    1
  • Spontaneous
    3
  • Targeted
    6
  • Genomic Mutations
    3 involving Spp1
Two alleles determine natural resistance/susceptibility to the lethal effects of the Gilliam strain of Rickettsia tsutsugamushi. Mice homozygous for a knock-out allele exhibit abnormal osteoclast physiology, macrophage recruitment, wound healing, response to injury, and inflammatory response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024389 VEGA Gene Model | MGI Sequence Detail 5933 C57BL/6J ±  kb
transcript OTTMUST00000059774 VEGA | MGI Sequence Detail 1411 Not Applicable  
polypeptide OTTMUSP00000029096 VEGA | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    149 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 1302
    Genomic 2
    cDNA 1281
    Primer pair 9
    Other 10

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-13036, MGD-MRK-13037, MGD-MRK-1359, MGD-MRK-13878, MGD-MRK-14544, MGD-MRK-14545, MGD-MRK-9656, MGI:2140792, MGI:2140963
References
more
  • Summaries
    All 440
    Developmental Gene Expression 179
    Gene Ontology 11
    Phenotypes 169
  • Earliest
    J:5949 Groves MG, et al., Host defenses in experimental scrub typhus: genetics of natural resistance to infection. Infect Immun. 1978 Feb;19(2):583-8
  • Latest
    J:229013 Liu ES, et al., c-Raf promotes angiogenesis during normal growth plate maturation. Development. 2016 Jan 15;143(2):348-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory