Spp1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Spp1
secreted phosphoprotein 1
MGI:98389

106 phenotypes from 6 alleles in 28 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Spp1^Ric-r/Spp1⁺ A/J	decreased susceptibility to bacterial infection	J:5949
Spp1^Ric-r/Spp1⁺ AKR/J	decreased susceptibility to bacterial infection	J:5949
Spp1^Ric-r/Spp1⁺ BALB/cJ	decreased susceptibility to bacterial infection	J:5949
Spp1^Ric-r/Spp1⁺ C3H/Rv	decreased susceptibility to bacterial infection induced morbidity/mortality	J:7240
Spp1^Ric-r/Spp1⁺ C3H/Rv	increased macrophage cell number	J:7240
Spp1^Ric-r/Spp1⁺ C57BL/6J	decreased susceptibility to bacterial infection	J:5949
Spp1^Ric-r/Spp1⁺ C57L/J	decreased susceptibility to bacterial infection	J:5949
Spp1^Ric-r/Spp1⁺ SWR/J	decreased susceptibility to bacterial infection	J:5949
Spp1^Ric-s/Spp1⁺ A/HeJ	increased susceptibility to bacterial infection	J:5949
Spp1^Ric-s/Spp1⁺ C3H/HeJ	increased susceptibility to bacterial infection	J:5949
Spp1^Ric-s/Spp1⁺ C3H/HeN	increased susceptibility to bacterial infection	J:5949
Spp1^Ric-s/Spp1⁺ C3H/St	increased susceptibility to bacterial infection	J:5949
Spp1^Ric-s/Spp1⁺ CBA/J	increased susceptibility to bacterial infection	J:5949
Spp1^Ric-s/Spp1⁺ DBA/1J	increased susceptibility to bacterial infection	J:5949
Spp1^Ric-s/Spp1⁺ DBA/2J	increased susceptibility to bacterial infection	J:5949
Spp1^Ric-s/Spp1⁺ SJL/J	increased susceptibility to bacterial infection	J:5949
Spp1^{tm1.1(KOMP)Vlcg}/Spp1^{tm1.1(KOMP)Vlcg} C57BL/6N-Spp1^{tm1.1(KOMP)Vlcg}/J	abnormal eyelid morphology	J:211773
	anophthalmia	J:211773
	exophthalmos	J:211773
	eye hemorrhage	J:211773
	eyelids fail to open	J:211773
Spp1^tm1.1Dhd/Spp1^tm1.1Dhd involves: 129P2/OlaHsd * C57BL/6	abnormal long bone metaphysis morphology	J:237104
	abnormal macrophage morphology	J:237104
	abnormal osteoclast physiology	J:237104
	decreased osteoclast cell number	J:237104
Spp1^tm1Blh/Spp1⁺ BKSW.129S6-Spp1^tm1Blh	abnormal immune system physiology	J:113585
Spp1^tm1Blh/Spp1⁺ BKSW.129S6-Spp1^tm1Blh	calcified aortic valve cusp	J:113585
Spp1^tm1Blh/Spp1⁺ involves: 129S6/SvEvTac * Black Swiss	abnormal leukocyte migration	J:86531
Spp1^tm1Blh/Spp1^tm1Blh 129S6/SvEvTac-Spp1^tm1Blh	decreased incidence of tumors by chemical induction	J:112122
Spp1^tm1Blh/Spp1^tm1Blh 129S/SvEv-Spp1^tm1Blh	crystalluria	J:127526
	decreased urine chloride ion level	J:127526
	decreased urine sodium level	J:127526
	nephrocalcinosis	J:127526
Spp1^tm1Blh/Spp1^tm1Blh B6.129S6(Cg)-Spp1^tm1Blh/J	abnormal hematopoietic system physiology	J:133795
	decreased hematocrit	J:133795
	decreased hemoglobin content	J:133795
	normal reproductive system phenotype	J:99574
Spp1^tm1Blh/Spp1^tm1Blh B6.129S6-Spp1^tm1Blh	abnormal microglial cell morphology	J:118432
	abnormal striatum morphology	J:118432
	abnormal substantia nigra morphology	J:118432
	decreased physiological sensitivity to xenobiotic	J:118432
	decreased susceptibility to dopaminergic neuron neurotoxicity	J:118432
	decreased susceptibility to experimental autoimmune uveoretinitis	J:116272
	granulomatous inflammation	J:116272
	increased neuron number	J:118432
Spp1^tm1Blh/Spp1^tm1Blh BKSW.129S6-Spp1^tm1Blh	abnormal immune system physiology	J:113585
	calcified aortic valve cusp	J:113585
	impaired macrophage chemotaxis	J:113585
Spp1^tm1Blh/Spp1^tm1Blh involves: 129S6/SvEvTac	abnormal bone mineralization	J:81625
Spp1^tm1Blh/Spp1^tm1Blh involves: 129S6/SvEvTac	increased bone mineral density	J:81625
Spp1^tm1Blh/Spp1^tm1Blh involves: 129S6/SvEvTac * Black Swiss	abnormal blood flow velocity	J:103050
	abnormal blood vessel morphology	J:103050
	abnormal blood vessel physiology	J:103050
	abnormal chemokine level	J:127389
	abnormal leukocyte migration	J:86531
	abnormal leukocyte physiology	J:86531
	abnormal macrophage chemotaxis	J:140014
	abnormal macrophage physiology	J:127389
	abnormal response to cardiac infarction	J:115399
	abnormal response to infection	J:103013
	abnormal susceptibility to infection	J:140014
	abnormal vascular wound healing	J:103050
	abnormal vasodilation	J:103050
	abnormal wound healing	J:46863
	crystalluria	J:103140
	decreased circulating glucose level	J:127389
	decreased circulating insulin level	J:127389
	decreased circulating interleukin-6 level	J:127389
	decreased circulating triglyceride level	J:127389
	decreased lean body mass	J:127389
	decreased leukocyte cell number	J:86531
	decreased macrophage cell number	J:127389
	decreased susceptibility to atherosclerosis	J:86531
	decreased systemic arterial blood pressure	J:103050
	decreased systemic arterial systolic blood pressure	J:103050
	granulomatous inflammation	J:140014
	normal homeostasis/metabolism phenotype	J:103140
	improved glucose tolerance	J:127389
	increased heart rate	J:103050
	increased insulin sensitivity	J:127389
	increased lung weight	J:115399
	increased lymphocyte cell number	J:103050
	increased physiological sensitivity to xenobiotic	J:108144
	increased respiratory quotient	J:127389
	lung cyst	J:108144
	normal mortality/aging	J:46863
	normal renal/urinary system phenotype	J:103140
Spp1^tm1Blh/Spp1^tm1Blh involves: 129S6/SvEvTac * C57BL/6	abnormal immune system physiology	J:119298
	decreased dendritic cell number	J:119298
	decreased physiological sensitivity to xenobiotic	J:119298
Spp1^tm1Rit/Spp1^tm1Rit B6.129S7-Spp1^tm1Rit	abnormal liver morphology	J:93915
	decreased acute inflammation	J:93915
	decreased interferon-gamma secretion	J:93915
	decreased physiological sensitivity to xenobiotic	J:93915
	decreased tumor necrosis factor secretion	J:93915
Spp1^tm1Rit/Spp1^tm1Rit involves: 129S7/SvEvBrd	abnormal blood cell morphology/development	J:117329
	abnormal bone mineralization	J:81625
	increased bone marrow cell number	J:117329
	increased bone mineral density	J:81625
	increased hematopoietic stem cell number	J:117329
	increased susceptibility to induced morbidity/mortality	J:117329
Spp1^tm1Rit/Spp1^tm1Rit involves: 129S7/SvEvBrd * C57BL/6	abnormal cardiovascular system physiology	J:95591
	abnormal inflammatory response	J:60284
	abnormal osteoblast physiology	J:128077
	abnormal osteoclast physiology	J:56353, J:68872
	abnormal physiological neovascularization	J:115395
	abnormal response to infection	J:60284
	decreased bone resorption	J:115395
	decreased cardiac muscle contractility	J:95591
	decreased fibroblast chemotaxis	J:106243
	decreased heart weight	J:95591
	decreased interferon-gamma secretion	J:60284
	decreased interleukin-12 secretion	J:60284
	decreased osteoclast cell number	J:115395
	decreased sensitivity to induced cell death	J:95591
	decreased susceptibility to Herpesvirales infection	J:60284
	decreased susceptibility to type IV hypersensitivity reaction	J:60284
	delayed wound healing	J:141747
	dilated renal tubule	J:56204
	hyporesponsive to tactile stimuli	J:120346
	increased blood urea nitrogen level	J:56204
	increased bone mineral density	J:128077
	increased bone mineral density of lumbar vertebrae	J:128077
	increased bone mineral density of presacral vertebrae	J:128077
	increased circulating creatinine level	J:56204
	increased interleukin-4 secretion	J:60284
	increased interleukin-10 secretion	J:60284
	increased osteoclast cell number	J:56353, J:56535
	increased susceptibility to injury	J:56204
	increased trabecular bone thickness	J:128077
	normal mortality/aging	J:56535
	normal nervous system phenotype	J:120346
	renal tubular necrosis	J:56204
	normal skeleton phenotype	J:56535

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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