Spp1tm1Blh
Targeted Allele Detail
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Symbol: |
Spp1tm1Blh |
Name: |
secreted phosphoprotein 1; targeted mutation 1, Brigid L Hogan |
MGI ID: |
MGI:1932083 |
Synonyms: |
eta1, Eta-1, Opn-, OPN-, OPN-KO |
Gene: |
Spp1 Location: Chr5:104582984-104588916 bp, + strand Genetic Position: Chr5, 50.68 cM
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Alliance: |
Spp1tm1Blh page
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Reduced diaphragm and cardiac fibrosis in Dmdmdx/Y Spp1tm1Blh/Spp1tm1Blh and Dmdmdx/Dmdmdx Spp1tm1Blh/Spp1tm1Blh mice compared to Dmdmdx/Dmdmdx mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:46863
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Parent Cell Line: |
TL1/TL-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A PGK neomycin resistance cassette replaced exons 4-7 of the Spp1 gene. No Spp1 transcript was detected by RT-PCR in embryonic fibroblasts or adult kidney from homozygous mutant animals. Spp1 transcript was not detected in homozygous mutant animals by in situ hybridization. Immunohistochemistry studies of adult kidney and bone did not detect protein in homozygous mutant mice.
(J:46863)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:46863 Liaw L, et al., Altered wound healing in mice lacking a functional osteopontin gene (spp1). J Clin Invest. 1998 Apr 1;101(7):1468-78 |
All: |
128 reference(s) |
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