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Targeted Allele Detail
Symbol: Spp1tm1Blh
Name: secreted phosphoprotein 1; targeted mutation 1, Brigid L Hogan
MGI ID: MGI:1932083
Synonyms: eta1, Eta-1, Opn-, OPN-, OPN-KO
Gene: Spp1  Location: Chr5:104582984-104588916 bp, + strand  Genetic Position: Chr5, 50.68 cM
Alliance: Spp1tm1Blh page
Reduced diaphragm and cardiac fibrosis in Dmdmdx/Y Spp1tm1Blh/Spp1tm1Blh and Dmdmdx/Dmdmdx Spp1tm1Blh/Spp1tm1Blh mice compared to Dmdmdx/Dmdmdx mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:46863
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK neomycin resistance cassette replaced exons 4-7 of the Spp1 gene. No Spp1 transcript was detected by RT-PCR in embryonic fibroblasts or adult kidney from homozygous mutant animals. Spp1 transcript was not detected in homozygous mutant animals by in situ hybridization. Immunohistochemistry studies of adult kidney and bone did not detect protein in homozygous mutant mice. (J:46863)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Spp1 Mutation:  29 strains or lines available
Original:  J:46863 Liaw L, et al., Altered wound healing in mice lacking a functional osteopontin gene (spp1). J Clin Invest. 1998 Apr 1;101(7):1468-78
All:  128 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory