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Sod1
Gene Detail
 Symbol
Name
ID
Sod1
superoxide dismutase 1, soluble
MGI:98351
Synonyms B430204E11Rik, Cu(2+)-Zn2+ superoxide dismutase, CuZnSOD, Cu/Zn-SOD, Ipo1, Ipo-1, Sod-1, SODC
Feature Type protein coding gene
Genetic Map
Chromosome 16
51.56 cM, cytoband B5-C3
Detailed Genetic Map ± 1 cM


Mapping data(56)
Sequence Map
Chr16:90220742-90226322 bp, + strand
From Ensembl annotation of GRCm38

  5581 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:392  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: superoxide dismutase [Cu-Zn]
Gene Tree: Sod1

Human
homologs
Human Homolog SOD1, superoxide dismutase 1, soluble
NCBI Gene ID 6647
neXtProt AC  NX_P00441
Human Synonyms  ALS, ALS1, HEL-S-44, homodimer, hSod1, IPOA, SOD
Human Chr (Location)  21q22.11; chr21:31659622-31668931 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SOD1
Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(20) Targeted(11)
Genomic Mutations involving Sod1 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit increased motor neuron loss after axonal injury and enhanced susceptibility to ischemic reperfusion injury. Homozygous females have irregular and small litters, and for some alleles exhibit immature ovarian follicles with few corpora lutea.
 
Human Diseases Modeled Using Mouse Sod1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Sod1 interacts with 7 markers (Mir101a, Mir101b, Mir155, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (128 annotations)
Process activation of MAPK activity, aging, ...
Component cell, cytoplasm, ...
Function antioxidant activity, chaperone binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (491)    Tissues (356)    Images (38)
Theiler Stages: 4, 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 351
Northern blot 90
Western blot 16
RT-PCR 34
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(5) cDNA(24) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022982 (Evidence)
Entrez Gene20655 (Evidence)
DFCITC1572135, TC1586699, TC1597259, TC1651349
DoTSDT.101215638, DT.101370212, DT.101370422, DT.40152870, DT.55107810
EC1.15.1.1
PDB3GTT, 3GTV, 3LTV
Consensus CDS ProjectCCDS37395.1
International Mouse Knockout Project StatusSod1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022982 Ensembl Gene Model | MGI Sequence Detail 5581 C57BL/6J ±  kb
transcript ENSMUST00000023707 Ensembl | MGI Sequence Detail 646 Not Applicable 
polypeptide ENSMUSP00000023707 Ensembl | MGI Sequence Detail 154 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(2)
Polymorphisms RFLP(14) : SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001424 Superoxide dismutase, copper/zinc binding domain
InterPro IPR018152 Superoxide dismutase, copper/zinc, binding site
Protein Ontology PR:000015399 superoxide dismutase [Cu-Zn]
References (Earliest) J:14869 Selander RK, et al., Protein polymorphism and genic heterozygosity in two European subspecies of the house mouse. Evolution. 1969;23:379-90
(Latest) J:211617 Sakellariou GK, et al., Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice. FASEB J. 2014 Apr;28(4):1666-81
All references(358)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11443, MGD-MRK-11444, MGD-MRK-14483, MGD-MRK-14485, MGI:2441859

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory