About   Help   FAQ
Sod1 Gene Detail
Summary
  • Symbol
    Sod1
  • Name
    superoxide dismutase 1, soluble
  • Synonyms
    B430204E11Rik, Cu(2+)-Zn2+ superoxide dismutase, CuZnSOD, Cu/Zn-SOD, Ipo1, Ipo-1, Sod-1, SODC
  • Feature Type
    protein coding gene
  • IDs
    MGI:98351
    NCBI Gene: 20655
  • Gene Overview
    MyGene.info: SOD1
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:90220762-90226333 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 51.56 cM, cytoband B5-C3
  • Mapping Data
    56 experiments
Strain
Comparison
more
  • SNPs within 2kb
    59 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98351
 protein coding gene Chr16:90220754-90226333 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023024
 protein coding gene Chr16:91140091-91145671 (+)
A/J MGP_AJ_G0022992
 protein coding gene Chr16:86895206-86900785 (+)
AKR/J MGP_AKRJ_G0022962
 protein coding gene Chr16:89501704-89507284 (+)
BALB/cJ MGP_BALBcJ_G0022994
 protein coding gene Chr16:87420949-87426529 (+)
C3H/HeJ MGP_C3HHeJ_G0022755
 protein coding gene Chr16:90065323-90070903 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023441
 protein coding gene Chr16:94102668-94108248 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020943
 protein coding gene Chr16:84614400-84620104 (+)
CAST/EiJ MGP_CASTEiJ_G0022274
 protein coding gene Chr16:90606201-90612048 (+)
CBA/J MGP_CBAJ_G0022724
 protein coding gene Chr16:98093322-98098902 (+)
DBA/2J MGP_DBA2J_G0022858
 protein coding gene Chr16:86800179-86805759 (+)
FVB/NJ MGP_FVBNJ_G0022832
 protein coding gene Chr16:85932241-85937821 (+)
LP/J MGP_LPJ_G0022928
 protein coding gene Chr16:90831078-90836658 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022853
 protein coding gene Chr16:102717136-102722716 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023459
 protein coding gene Chr16:90022223-90027803 (+)
PWK/PhJ MGP_PWKPhJ_G0022019
 protein coding gene Chr16:86955723-86961641 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021849
 protein coding gene Chr16:89567132-89572734 (+)
WSB/EiJ MGP_WSBEiJ_G0022326
 protein coding gene Chr16:90256926-90262506 (+)



Homology
more
  • Human Ortholog
    SOD1, superoxide dismutase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOD1, superoxide dismutase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALS, ALS1, HEL-S-44, homodimer, hSod1, IPOA, SOD, STAHP
  • Links
    NCBI Gene ID: 6647
    neXtProt AC: NX_P00441
    UniProt: P00441

  • Chr Location
    21q22.11; chr21:31659622-31668931 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    3 with Sod1 mouse models; 1 with human SOD1 associations

Human Disease Mouse Models
      
IDs
 View 39 models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    30 with disease annotations
  • References
    37 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    142 phenotypes from 9 alleles in 11 genetic backgrounds
    222 phenotypes from multigenic genotypes
    7 images
    1039 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit increased motor neuron loss after axonal injury and enhanced susceptibility to ischemic reperfusion injury. Homozygous females have irregular and small litters, and for some alleles exhibit immature ovarian follicles with few corpora lutea. Homozygous KO also causes progressive age-related retinal degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    138
  • GO References
    50
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    509
  • cDNA Data
    22
  • Literature Summary
    35
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20655 NCBI Gene Model | MGI Sequence Detail 5572 C57BL/6J ±  kb
    transcript NM_011434 RefSeq | MGI Sequence Detail 652 Not Specified  
    polypeptide P08228 UniProt | EBI | MGI Sequence Detail 154 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 5
      cDNA 25
      Primer pair 4
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11443, MGD-MRK-11444, MGD-MRK-14483, MGD-MRK-14485, MGI:2441859
    References
    more
    • Summaries
      All 1262
      Developmental Gene Expression 35
      Diseases 37
      Gene Ontology 50
      Phenotypes 1039
    • Earliest
      J:14869 Selander RK, et al., Protein polymorphism and genic heterozygosity in two European subspecies of the house mouse. Evolution. 1969;23:379-90
    • Latest
      J:282040 Saba L, et al., Modified age-dependent expression of NaV1.6 in an ALS model correlates with motor cortex excitability alterations. Neurobiol Dis. 2019 Oct;130:104532
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    01/14/2020
    MGI 6.14     		The Jackson Laboratory