Sod1
Gene Detail

Symbol

Name
ID

Sod1
superoxide dismutase 1, soluble
MGI:98351

Synonyms

B430204E11Rik, Cu(2+)-Zn2+ superoxide dismutase, CuZnSOD, Cu/Zn-SOD, Ipo1, Ipo-1, Sod-1, SODC

Feature Type

protein coding gene

Genetic Map

Chromosome 16
51.56 cM, cytoband B5-C3
Detailed Genetic Map ± 1 cM


Mapping data(56)

Sequence Map

Chr16:90220742-90226322 bp, + strand From Ensembl annotation of GRCm38   5581 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:392  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: superoxide dismutase [Cu-Zn]
Gene Tree: Sod1

Human
homologs

Human Homolog		SOD1, superoxide dismutase 1, soluble
NCBI Gene ID		6647
neXtProt AC		NX_P00441
Human Synonyms		ALS, ALS1, HEL-S-44, homodimer, hSod1, IPOA, SOD
Human Chr (Location)		21q22.11; chr21:31659622-31668931 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human SOD1

Mutations,
alleles, and
phenotypes

All mutations/alleles(62) : Gene trapped(20) Targeted(13) Transgenic(29)
Genomic Mutations involving Sod1 (5)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutants exhibit increased motor neuron loss after axonal injury and enhanced susceptibility to ischemic reperfusion injury. Homozygous females have irregular and small litters, and for some alleles exhibit immature ovarian follicles with few corpora lutea.

 
Human Diseases Modeled in Mice Using Sod1 (2)    Mutations Annotated to Human Diseases (24)    Phenotype Images(5)

Interactions

Sod1 interacts with 7 markers (Mir101a, Mir101b, Mir155, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (129 annotations)

Process	activation of MAPK activity, aging, ...
Component	cell, cytoplasm, ...
Function	antioxidant activity, chaperone binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (27 records)

Data Summary: Results (491)    Tissues (356)    Images (38)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	351
Northern blot	90
Western blot	16
RT-PCR	34

cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(33) Genomic(5) cDNA(24) Primer pair(3) Other(1)
Microarray probesets(5)

Other database
links

Ensembl Gene Model	ENSMUSG00000022982 (Evidence)
Entrez Gene	20655 (Evidence)
DFCI	TC1572135, TC1586699, TC1597259, TC1651349
DoTS	DT.101215638, DT.101370212, DT.101370422, DT.40152870, DT.55107810
EC	1.15.1.1
PDB	3GTT, 3GTV, 3LTV
Consensus CDS Project	CCDS37395.1
International Mouse Knockout Project Status	Sod1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022982	Ensembl Gene Model | MGI Sequence Detail	5581	C57BL/6J
transcript	ENSMUST00000023707	Ensembl | MGI Sequence Detail	646	Not Applicable
polypeptide	ENSMUSP00000023707	Ensembl | MGI Sequence Detail	154	Not Applicable

All sequences(39) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(14) : SNPs within 2kb(59 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001424	Superoxide dismutase, copper/zinc binding domain
InterPro	IPR018152	Superoxide dismutase, copper/zinc, binding site
Protein Ontology	PR:000015399	superoxide dismutase [Cu-Zn]

References

(Earliest) J:14869 Selander RK, et al., Protein polymorphism and genic heterozygosity in two European subspecies of the house mouse. Evolution. 1969;23:379-90
(Latest) J:216815 Shi Y, et al., The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice. PLoS One. 2014;9(6):e100834
All references(364)
Disease annotation references (1)

Other
accession IDs

MGD-MRK-11443, MGD-MRK-11444, MGD-MRK-14483, MGD-MRK-14485, MGI:2441859