Sod1
Gene Detail

Symbol Name ID

Sod1 superoxide dismutase 1, soluble MGI:98351

Synonyms

B430204E11Rik, Cu(2+)-Zn2+ superoxide dismutase, CuZnSOD, Cu/Zn-SOD, Ipo1, Ipo-1, Sod-1, SODC

Feature Type

protein coding gene

Genetic Map

Chromosome 16

51.56 cM, cytoband B5-C3
Detailed Genetic Map ± 1 cM


Mapping data(56)

Sequence Map

Chr16:90220742-90226322 bp, + strand From Ensembl annotation of GRCm38   5581 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cat, domestic; cattle; chimpanzee; dog, domestic; goat; horse; pig, domestic; rabbit, European; sheep    (Mammalian Orthology)
Comparative Map (Mouse/Human Sod1 ± 2 cM)

Protein SuperFamily: superoxide dismutase [Cu-Zn]
Gene Tree: Sod1

Human ortholog

SOD1 superoxide dismutase 1, soluble NCBI Gene ID 6647
Human Synonyms: ALS, ALS1, homodimer, hSod1, IPOA, SOD
Human Chr21:33031935-33041244 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human SOD1 (1)

Alleles and phenotypes

All alleles(27) : Targeted(7) Gene trapped(20)
 

Homozygous mutants exhibit increased motor neuron loss after axonal injury and enhanced susceptibility to ischemic reperfusion injury. Homozygous females have irregular and small litters, and for some alleles exhibit immature ovarian follicles with few corpora lutea.

 
Human Diseases Modeled Using Mouse Sod1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (118 annotations)

Process	activation of MAPK activity, aging, ...
Component	cytoplasm, cytoplasmic vesicle, ...
Function	antioxidant activity, chaperone binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (492)    Tissues (351)    Images (38)
Theiler Stages: 4, 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	351
Northern blot	90
Western blot	16
RT-PCR	35

cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(5) cDNA(24) Primer pair(3) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000022982 (Evidence)
Entrez Gene	20655 (Evidence)
DFCI	TC1572135, TC1586699, TC1597259, TC1651349
DoTS	DT.101215638, DT.101370212, DT.101370422, DT.40152870, DT.55107810
EC	1.15.1.1
PDB	3GTT, 3GTV
Consensus CDS Project	CCDS37395.1
International Mouse Knockout Project Status	Sod1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022982	Ensembl Gene Model | MGI Sequence Detail	5581	C57BL/6J
transcript	ENSMUST00000023707	Ensembl | MGI Sequence Detail	646	Not Applicable
polypeptide	ENSMUSP00000023707	Ensembl | MGI Sequence Detail	154	Not Applicable

All sequences(39) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(14) : SNPs(23 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001424	Superoxide dismutase, copper/zinc binding domain
InterPro	IPR018152	Superoxide dismutase, copper/zinc, binding site
InterPro	IPR024134	Superoxide dismutase (Cu/Zn) / chaperones
Protein Ontology	PR:000015399	superoxide dismutase [Cu-Zn]

References

(Earliest) J:14869 Selander RK, et al., Protein polymorphism and genic heterozygosity in two European subspecies of the house mouse. Evolution. 1969;23:379-90
(Latest) J:192588 Roberts K, et al., Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype. Glia. 2013 Mar;61(3):409-19
All references(334)

Other accession IDs

MGD-MRK-11443, MGD-MRK-11444, MGD-MRK-14483, MGD-MRK-14485, MGI:2441859