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Sod1 Gene Detail
Summary
  • Symbol
    Sod1
  • Name
    superoxide dismutase 1, soluble
  • Synonyms
    B430204E11Rik, Cu(2+)-Zn2+ superoxide dismutase, CuZnSOD, Cu/Zn-SOD, Ipo1, Ipo-1, Sod-1, SODC
  • Feature Type
    protein coding gene
  • IDs
    MGI:98351
    NCBI Gene: 20655
  • Gene Overview
    MyGene.info: SOD1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr16:90220742-90226322 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      5581 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 51.56 cM, cytoband B5-C3
  • Mapping Data
    56 experiments
Homology
more
  • Human Ortholog
    SOD1, superoxide dismutase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOD1, superoxide dismutase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALS, ALS1, HEL-S-44, homodimer, hSod1, IPOA, SOD
  • Links
    NCBI Gene ID: 6647
    neXtProt AC: NX_P00441
    UniProt: P00441

  • Chr Location
    21q22.11; chr21:31659622-31668931 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    3 with Sod1 mouse models; 1 with human SOD1 associations

Human Disease Mouse Models
      
IDs
 View 38 models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    29 with disease annotations
  • References
    36 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    137 phenotypes from 9 alleles in 10 genetic backgrounds
    213 phenotypes from multigenic genotypes
    5 images
    938 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit increased motor neuron loss after axonal injury and enhanced susceptibility to ischemic reperfusion injury. Homozygous females have irregular and small litters, and for some alleles exhibit immature ovarian follicles with few corpora lutea.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    129
  • GO References
    48
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    503
  • cDNA Data
    22
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022982 Ensembl Gene Model | MGI Sequence Detail 5581 C57BL/6J ±  kb
    transcript ENSMUST00000023707 Ensembl | MGI Sequence Detail 646 Not Applicable  
    polypeptide ENSMUSP00000023707 Ensembl | MGI Sequence Detail 154 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      59 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 5
      cDNA 25
      Primer pair 4
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11443, MGD-MRK-11444, MGD-MRK-14483, MGD-MRK-14485, MGI:2441859
    References
    more
    • Summaries
      All 1160
      Developmental Gene Expression 34
      Diseases 36
      Gene Ontology 48
      Phenotypes 938
    • Earliest
      J:14869 Selander RK, et al., Protein polymorphism and genic heterozygosity in two European subspecies of the house mouse. Evolution. 1969;23:379-90
    • Latest
      J:263107 Varga B, et al., Myotube elasticity of an amyotrophic lateral sclerosis mouse model. Sci Rep. 2018 Apr 12;8(1):5917
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/31/2018
    MGI 6.12     		The Jackson Laboratory