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Sod1
Gene Detail
Symbol

Name
ID
Sod1
superoxide dismutase 1, soluble
MGI:98351
Synonyms
B430204E11Rik, Cu(2+)-Zn2+ superoxide dismutase, CuZnSOD, Cu/Zn-SOD, Ipo1, Ipo-1, Sod-1, SODC
Feature Type
protein coding gene
Genetic Map
Chromosome 16
51.56 cM, cytoband B5-C3
Detailed Genetic Map ± 1 cM


Mapping data(56)
Sequence Map
Chr16:90220742-90226322 bp, + strand
From Ensembl annotation of GRCm38

  5581 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:392  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SOD1
Protein SuperFamily: superoxide dismutase [Cu-Zn]
Gene Tree: Sod1

Human
homologs
SOD1, superoxide dismutase 1, soluble
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6647
neXtProt AC: NX_P00441

Human Synonyms: ALS, ALS1, HEL-S-44, homodimer, hSod1, IPOA, SOD

Human Chr (Location): 21q22.11; chr21:31659622-31668931 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SOD1

Mutations,
alleles, and
phenotypes
All mutations/alleles(62) : Gene trapped(20) Targeted(13) Transgenic(29)
Genomic Mutations involving Sod1 (5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit increased motor neuron loss after axonal injury and enhanced susceptibility to ischemic reperfusion injury. Homozygous females have irregular and small litters, and for some alleles exhibit immature ovarian follicles with few corpora lutea.
 
Human Diseases Modeled in Mice Using Sod1 (2)    Mutations Annotated to Human Diseases (24)    Phenotype Images(5)
Interactions
Sod1 interacts with 7 markers (Mir101a, Mir101b, Mir155, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (131 annotations)
Process activation of MAPK activity, aging, ...
Component cell, cytoplasm, ...
Function antioxidant activity, chaperone binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (491)    Tissues (356)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 351
Northern blot 90
Western blot 16
RT-PCR 34
cDNA source data(21)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase sod1 ; ZFIN sod1    NEW 
Molecular
reagents
All nucleic(33) Genomic(5) cDNA(24) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000022982 (Evidence)
Entrez Gene 20655 (Evidence)
DFCI TC1572135, TC1586699, TC1597259, TC1651349
DoTS DT.101215638, DT.101370212, DT.101370422, DT.40152870, DT.55107810
EC 1.15.1.1
PDB 3GTT, 3GTV, 3LTV
Consensus CDS Project CCDS37395.1
International Mouse Phenotyping Consortium Status Sod1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022982 Ensembl Gene Model | MGI Sequence Detail 5581 C57BL/6J ±  kb
transcript ENSMUST00000023707 Ensembl | MGI Sequence Detail 646 Not Applicable 
polypeptide ENSMUSP00000023707 Ensembl | MGI Sequence Detail 154 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(14) : SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001424 Superoxide dismutase, copper/zinc binding domain
InterPro IPR018152 Superoxide dismutase, copper/zinc, binding site
Protein Ontology PR:000015399 superoxide dismutase [Cu-Zn]
References
(Earliest) J:14869 Selander RK, et al., Protein polymorphism and genic heterozygosity in two European subspecies of the house mouse. Evolution. 1969;23:379-90
(Latest) J:219024 Ibrahim OM, et al., Oxidative stress induced age dependent meibomian gland dysfunction in Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice. PLoS One. 2014;9(7):e99328
All references(358)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-11443, MGD-MRK-11444, MGD-MRK-14483, MGD-MRK-14485, MGI:2441859

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory