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Sod1 Gene Detail
Summary
  • Symbol
    Sod1
  • Name
    superoxide dismutase 1, soluble
  • Synonyms
    B430204E11Rik, Cu(2+)-Zn2+ superoxide dismutase, CuZnSOD, Cu/Zn-SOD, Ipo1, Ipo-1, Sod-1, SODC
  • Feature Type
    protein coding gene
  • IDs
    MGI:98351
    NCBI Gene: 20655
Location & Maps
more
  • Sequence Map
    Chr16:90220742-90226322 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5581 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SOD1, superoxide dismutase 1, soluble
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOD1, superoxide dismutase 1, soluble
    Orthology source: HomoloGene
  • Synonyms
    ALS, ALS1, HEL-S-44, homodimer, hSod1, IPOA, SOD
  • Links
    NCBI Gene ID: 6647
    neXtProt AC: NX_P00441

  • Chr Location
    21q22.11; chr21:31659622-31668931 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Sod1 mouse models; 1 with human SOD1 associations

Human Disease Mouse Models
       Amyotrophic Lateral Sclerosis 1; ALS1   OMIM: 105400 View 37 models
       Glaucoma, Normal Tension, Susceptibility to   OMIM: 606657 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    28 with disease annotations
  • References
    114 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    114 phenotypes from 8 alleles in 9 genetic backgrounds
    212 phenotypes from multigenic genotypes
    5 images
    782 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    75
  • Chemically induced (ENU)
    1
  • Gene trapped
    20
  • Targeted
    13
  • Transgenic
    41
  • Genomic Mutations
    5 involving Sod1
  • Incidental Mutations
Homozygous mutants exhibit increased motor neuron loss after axonal injury and enhanced susceptibility to ischemic reperfusion injury. Homozygous females have irregular and small litters, and for some alleles exhibit immature ovarian follicles with few corpora lutea.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022982 Ensembl Gene Model | MGI Sequence Detail 5581 C57BL/6J ±  kb
transcript ENSMUST00000023707 Ensembl | MGI Sequence Detail 646 Not Applicable  
polypeptide ENSMUSP00000023707 Ensembl | MGI Sequence Detail 154 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    59 from dbSNP Build 137
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015399 superoxide dismutase [Cu-Zn]
  • PDB
  • EC
  • InterPro Domains
    IPR001424 Superoxide dismutase, copper/zinc binding domain
    IPR018152 Superoxide dismutase, copper/zinc, binding site
    IPR024134 Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone
Molecular
Reagents
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  • All nucleic 33
    Genomic 5
    cDNA 24
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11443, MGD-MRK-11444, MGD-MRK-14483, MGD-MRK-14485, MGI:2441859
References
more
  • Summaries
    All 363
    Developmental Gene Expression 28
    Diseases 114
    Gene Ontology 47
    Phenotypes 782
  • Earliest
    J:14869 Selander RK, et al., Protein polymorphism and genic heterozygosity in two European subspecies of the house mouse. Evolution. 1969;23:379-90
  • Latest
    J:226973 Henriques A, et al., Amyotrophic lateral sclerosis and denervation alter sphingolipids and up-regulate glucosylceramide synthase. Hum Mol Genet. 2015 Dec 20;24(25):7390-405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory