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Pthlh
Gene Detail
 Symbol
Name
ID
Pthlh
parathyroid hormone-like peptide
MGI:97800
STS D6Mit26
Synonyms parathyroid hormone-like hormone, parathyroid hormone-related peptide, parathyroid hormone-related protein, PTH-like, PTH-related peptide, Pthrp
Feature Type protein coding gene
Genetic Map
Chromosome 6
78.19 cM, cytoband F-G
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:147252101-147264167 bp, - strand
From VEGA annotation of GRCm38

  12067 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2113  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: parathyroid hormone-related protein
Gene Tree: Pthlh

Human
homologs
Human Homolog PTHLH, parathyroid hormone-like hormone
NCBI Gene ID 5744
neXtProt AC  NX_P12272
Human Synonyms  BDE2, HHM, PLP, PTHR, PTHRP
Human Chr (Location)  12p12.1-p11.2; chr12:27958084-27971983 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human PTHLH
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit dischondroplasia associated with premature maturation of chondrocytes and die postnatally from asphyxia. Mutants rescued from neonatal lethality lack mammary development and tooth eruption.
 
Human Diseases Modeled Using Mouse Pthlh (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(9)
Interactions
Pthlh interacts with 162 markers (Mir10a, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process adenylate cyclase-activating G-protein coupled receptor signaling pathway, endochondral ossification, ...
Component cytoplasm, extracellular region, ...
Function hormone activity, peptide hormone receptor binding
External Resources: FuncBase
Expression
Literature Summary: (86 records)
Data Summary: Results (104)    Tissues (68)    Images (29)
Theiler Stages: 1, 2, 3, 4, 15, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 41
In situ reporter (knock in) 48
RT-PCR 10
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(4) cDNA(17) Primer pair(2) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026067 (Evidence)
Ensembl Gene ModelENSMUSG00000048776 (Evidence)
Entrez Gene19227 (Evidence)
DFCITC1583824, TC1657151
DoTSDT.522903, DT.94287965
NIA Mouse Gene IndexU028042
Consensus CDS ProjectCCDS39717.1
International Mouse Knockout Project StatusPthlh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026067 VEGA Gene Model | MGI Sequence Detail 12067 C57BL/6J ±  kb
transcript OTTMUST00000064342 VEGA | MGI Sequence Detail 1603 Not Applicable 
polypeptide OTTMUSP00000031937 VEGA | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(73 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001415 Parathyroid hormone/parathyroid hormone-related protein
InterPro IPR003626 Parathyroid hormone-related protein
Protein Ontology PR:000013433 parathyroid hormone-related protein
References (Earliest) J:9894 Yasuda T, et al., Rat parathyroid hormone-like peptide: comparison with the human homologue and expression in malignant and normal tissue. Mol Endocrinol. 1989 Mar;3(3):518-25
(Latest) J:205339 Mis EK, et al., Forward genetics defines Xylt1 as a key, conserved regulator of early chondrocyte maturation and skeletal length. Dev Biol. 2014 Jan 1;385(1):67-82
All references(205)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13668

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory