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Pthlh Gene Detail
Summary
  • Symbol
    Pthlh
  • Name
    parathyroid hormone-like peptide
  • Synonyms
    parathyroid hormone-like hormone, parathyroid hormone-related peptide, parathyroid hormone-related protein, PTH-like, PTH-related peptide, Pthrp
  • Feature Type
    protein coding gene
  • IDs
    MGI:97800
    NCBI Gene: 19227
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:147153607-147165511 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 78.19 cM, cytoband F-G
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97800
 protein coding gene Chr6:147153599-147165681 (-)
129S1/SvImJ ENSMUSG00200002959
 protein coding gene Chr6:144699363-144711421 (-)
A/J ENSMUSG00195003687
 protein coding gene Chr6:143605822-143617882 (-)
AKR/J ENSMUSG00220030815
 protein coding gene Chr6:141850470-141862558 (-)
BALB/cJ ENSMUSG00180002351
 protein coding gene Chr6:143732997-143745064 (-)
C3H/HeJ ENSMUSG00175002455
 protein coding gene Chr6:143639202-143651278 (-)
C57BL/6NJ ENSMUSG00215003528
 protein coding gene Chr6:143808528-143820612 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029067
 protein coding gene Chr6:145000787-145012082 (-)
CAST/EiJ ENSTCUG00005010400
 protein coding gene Chr6:144447398-144459499 (-)
CBA/J ENSMUSG00210004447
 protein coding gene Chr6:143709194-143721256 (-)
DBA/2J ENSMUSG00185015212
 protein coding gene Chr6:144352051-144364125 (-)
FVB/NJ ENSMUSG00205021019
 protein coding gene Chr6:142688077-142700144 (-)
JF1/MsJ ENSUMUG00000006570
 protein coding gene Chr6:143018460-143030538 (-)
LP/J ENSMUSG00230004399
 protein coding gene Chr6:145464183-145476240 (-)
NOD/ShiLtJ ENSMUSG00190002133
 protein coding gene Chr6:144191827-144203889 (-)
NZO/HlLtJ ENSMUSG00225013108
 protein coding gene Chr6:148354071-148366149 (-)
PWK/PhJ ENSLUMG00010030538
 protein coding gene Chr6:142090857-142102903 (-)
SPRET/EiJ ENSMSPG00010016397
 protein coding gene Chr6:146022826-146034994 (-)
WSB/EiJ ENSIUOG00005004462
 protein coding gene Chr6:144393541-144405606 (-)



Homology
more
  • Human Ortholog
    PTHLH, parathyroid hormone like hormone
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTHLH, parathyroid hormone like hormone
  • Synonyms
    BDE2, HHM, PLP, PTHR, PTHRP
  • Links
    NCBI Gene ID: 5744
    UniProt: P12272

  • Chr Location
    12p11.22; chr12:27958084-27972755 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Pthlh mouse models; 1 with human PTHLH associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    114 phenotypes from 7 alleles in 13 genetic backgrounds
    62 phenotypes from multigenic genotypes
    9 images
    107 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit dischondroplasia associated with premature maturation of chondrocytes and die postnatally from asphyxia. Mutants rescued from neonatal lethality lack mammary development and tooth eruption.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    938
  • Tissues
    150
  • cDNA Data
    13
  • Literature Summary
    137
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19227 NCBI Gene Model | MGI Sequence Detail 11905 C57BL/6J ±  kb
    transcript NM_008970 RefSeq | MGI Sequence Detail 1455 ZRU/MplStud  
    polypeptide P22858 UniProt | EBI | MGI Sequence Detail 175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 4
      cDNA 20
      Primer pair 7
      Other 10
      Antibodies 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13668
    References
    more
    • Summaries
      All 317
      Developmental Gene Expression 137
      Diseases 1
      Gene Ontology 18
      Phenotypes 107
    • Earliest
      J:9894 Yasuda T, et al., Rat parathyroid hormone-like peptide: comparison with the human homologue and expression in malignant and normal tissue. Mol Endocrinol. 1989 Mar;3(3):518-25
    • Latest
      J:389703 Komori T, et al., Wnt-dependent ontogeny of acellular cementum-forming cementoblasts on the tooth root surface. Nat Commun. 2026 May 13;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory