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Symbol Name ID |
Pthlh
parathyroid hormone-like peptide MGI:97800 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Brachydactyly |
Short metatarsal |
Short metacarpal |
| Disease(s) Associated with PTHLH | |||
| brachydactyly type E2 |
| Mouse Phenotypes | skeleton phenotype |
increased chondrocyte apoptosis |
increased osteocyte apoptosis |
increased osteoblast apoptosis |
abnormal osteoblast differentiation |
decreased chondrocyte proliferation |
abnormal cranium morphology |
failure of tooth eruption |
abnormal mandible morphology |
short mandible |
domed cranium |
decreased osteoclast cell number |
abnormal osteoclast morphology |
short humerus |
short radius |
short ulna |
short femur |
short tibia |
abnormal long bone morphology |
abnormal clavicle morphology |
abnormal long bone epiphyseal plate morphology |
abnormal long bone epiphyseal plate proliferative zone |
abnormal long bone hypertrophic chondrocyte zone |
increased width of hypertrophic chondrocyte zone |
decreased long bone epiphyseal plate size |
disorganized long bone epiphyseal plate |
abnormal long bone metaphysis morphology |
decreased length of long bones |
increased diameter of long bones |
abnormal sternum ossification |
short sternum |
abnormal axial skeleton morphology |
abnormal rib morphology |
abnormal cervical rib |
short ribs |
splayed ribs |
abnormal thoracic cage shape |
kyphosis |
abnormal vertebral body morphology |
abnormal bone structure |
decreased bone mineral density |
increased compact bone thickness |
abnormal osteoblast morphology |
decreased osteoblast cell number |
increased osteoblast cell number |
abnormal trabecular bone morphology |
abnormal bone trabecula morphology |
osteoporosis |
increased bone mass |
abnormal cartilage development |
decreased chondrocyte number |
abnormal skeleton development |
chondrodystrophy |
abnormal bone ossification |
abnormal bone mineralization |
premature endochondral bone ossification |
premature bone ossification |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pthlhtm1a(KOMP)Wtsi/Pthlhtm1a(KOMP)Wtsi | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pthlhtm1Broa/Pthlhtm1Broa | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pthlhtm1Fbe/Pthlhtm1Fbe | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pthlhtm1Hmk/Pthlhtm1Hmk | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pthlhtm2Ack/Pthlhtm2Ack | * | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pthlhtm1a(KOMP)Wtsi/Pthlh+ | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pthlhtm1Hmk/Pthlh+ | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pthlhtm1Ack/Pthlhtm1Ack Tg(Col1a1-cre)1Ack/0 (conditional) |
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| Pthlhtm1Ack/Pthlhtm1.1Ack Tmem163Tg(ACTB-cre)2Mrt/0 (conditional) |
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| Pthlhtm1Ack/Pthlhtm1Hmk Tmem163Tg(ACTB-cre)2Mrt/0 (conditional) |
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| Pthlhtm1Ack/Pthlhtm1Hmk Tg(LGB-cre)74Acl/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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