Sequence Detail

ID/Version

P22858 (UniProt | EBI)

Last sequence update: 1991-08-01
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Parathyroid hormone-related protein {ECO:0000303|PubMed:2249778}; Short=PTH-rP; Short=PTHrP {ECO:0000303|PubMed:17301089};AltName: Full=Parathyroid hormone-like protein; Short=PLP;Contains: RecName: Full=Osteostatin;

Provider

SWISS-PROT

Sequence

Polypeptide 175 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pthlh	parathyroid hormone-like peptide	55	133	4	12

Sequence references in MGI

J:10854 Mangin M, et al., Structure of the mouse gene encoding parathyroid hormone-related peptide. Gene. 1990 Nov 15;95(2):195-202
J:16911 Karaplis AC, et al., Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 1994 Feb 1;8(3):277-89
J:60156 Lee K, et al., Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology. 1996 Nov;137(11):5109-18
J:118865 Hens JR, et al., BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Development. 2007 Mar;134(6):1221-30
J:208750 Guo J, et al., Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH. Endocrinology. 2010 Aug;151(8):3502-13