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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pthlh
parathyroid hormone-like peptide
MGI:97800
62 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fgfr3tm1Dor/Fgfr3tm1Dor
Pthlhtm1Fbe/Pthlhtm1Fbe
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ 		abnormal axial skeleton morphology J:109505
abnormal long bone epiphyseal plate morphology J:109505
abnormal long bone hypertrophic chondrocyte zone J:109505
decreased long bone epiphyseal plate size J:109505
domed cranium J:109505
increased width of hypertrophic chondrocyte zone J:109505
neonatal lethality, complete penetrance J:109505
short femur J:109505
short humerus J:109505
short limbs J:109505
short radius J:109505
short ulna J:109505
Pthtm1Dgo/Pthtm1Dgo
Pthlhtm1Hmk/Pthlhtm1Hmk
involves: 129S2/SvPas * C57BL/6J 		abnormal angiogenesis J:76407
abnormal appendicular skeleton morphology J:76407
abnormal axial skeleton morphology J:76407
abnormal bone mineralization J:76407
abnormal bone structure J:76407
abnormal cartilage development J:76407
abnormal long bone epiphyseal plate proliferative zone J:76407
abnormal long bone hypertrophic chondrocyte zone J:76407
abnormal osteoclast morphology J:76407
abnormal skeleton morphology J:76407
abnormal trabecular bone morphology J:76407
decreased length of long bones J:76407
decreased osteoblast cell number J:76407
decreased osteoclast cell number J:76407
disproportionate dwarf J:76407
enlarged parathyroid gland J:76407
increased chondrocyte apoptosis J:76407
increased compact bone thickness J:76407
increased osteoblast apoptosis J:76407
increased osteocyte apoptosis J:76407
increased width of hypertrophic chondrocyte zone J:76407
perinatal lethality, complete penetrance J:76407
short limbs J:76407
Pthlhtm1Hmk/Pthlh+
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB/N 		decreased long bone epiphyseal plate size J:99641
Pthlhtm1Hmk/Pthlh+
Tg(Col2a1-GAL4)1Amc/0
Tg(UAS-IHH)1Amc/0
involves: 129S2/SvPas * C57BL/6 		decreased long bone epiphyseal plate size J:99641
Pthlhtm1Hmk/Pthlhtm1Hmk
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Bglap2-cre)1Kry/0
Tg(Col2a1-PTHLH)1Ecw/0
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * FVB * SJL 		abnormal chondrocyte differentiation J:99641
abnormal long bone epiphyseal plate morphology J:99641
long tibia J:99641
Pthlhtm1Hmk/Pthlhtm1Hmk
Pth1rtm1Hmk/Pth1rtm2Hmk
Tg(Col2a1-PTHLH)1Ecw/0
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * SJL 		abnormal bone marrow development J:99641
abnormal bone ossification J:99641
abnormal long bone epiphyseal plate morphology J:99641
short tibia J:99641
Pthlhtm1Hmk/Pthlhtm1Hmk
Tg(Col2a1-GAL4)1Amc/0
Tg(Col2a1-PTHR1*H223R)AHju/?
Tg(UAS-IHH)1Amc/0
involves: 129S2/SvPas * C57BL/6 		abnormal long bone epiphyseal plate morphology J:99641
Pthlhtm1Hmk/Pthlhtm1Hmk
Tg(Col2a1-PTHLH)2Ecw/0
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal ameloblast morphology J:50144
abnormal enamel morphology J:50144
abnormal molar morphology J:50144
abnormal neurocranium morphology J:50144
abnormal tooth development J:50144
absent tooth root J:50144
chondrodystrophy J:50144
decreased body size J:50144
disproportionate dwarf J:50144
exophthalmos J:50144
failure of tooth eruption J:50144
flattened snout J:50144
frontal bossing J:50144
postnatal lethality, incomplete penetrance J:50144
premature death J:50144
shallow orbits J:50144
short limbs J:50144
short mandible J:50144
short maxilla J:50144
tooth ankylosis J:50144
tooth impaction J:50144
Pthlhtm1Hmk/Pthlhtm1Hmk
Tg(Col2a1-PTHLH)2Ecw/0
Tg(KRT14-PTHLH)7Wmp/0
involves: 129S2/SvPas * C57BL/6 * SJL 		chondrodystrophy J:50144
decreased body size J:50144
decreased body weight J:50144
long lower incisors J:50144
malocclusion J:50144
premature death J:50144
short maxilla J:50144
Pthlhtm1Hmk/Pthlhtm1Hmk
Tg(Col2a1-PTHR1*H223R)AHju/0
involves: 129S2/SvPas * C57BL/6 		abnormal long bone hypertrophic chondrocyte zone J:99641
premature death J:77639
normal skeleton phenotype J:77639
Pthlhtm1Hmk/Pthlhtm1Hmk
Tg(Col2a1-PTHR1*H223R)AHju/Tg(Col2a1-PTHR1*H223R)AHju
involves: 129S2/SvPas * C57BL/6 		abnormal ameloblast morphology J:77639
abnormal long bone epiphyseal plate morphology J:77639
abnormal odontoblast morphology J:77639
abnormal postnatal growth J:77639
abnormal tooth morphology J:77639
failure of tooth eruption J:77639
premature death J:77639
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory