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Pparg
Gene Detail
Symbol

Name
ID
Pparg
peroxisome proliferator activated receptor gamma
MGI:97747
Synonyms
Nr1c3, PPARgamma, PPAR-gamma, Ppar-gamma2, PPARgamma2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
53.41 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr6:115361221-115490401 bp, + strand
From Ensembl annotation of GRCm38

  129181 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7899  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: peroxisome proliferator activated receptor (PPAR)
Gene Tree: Pparg

Human
homologs
Human Homolog PPARG, peroxisome proliferator-activated receptor gamma
NCBI Gene ID 5468
neXtProt AC  NX_P37231
Human Synonyms  CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma
Human Chr (Location)  3p25; chr3:12287850-12434356 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human PPARG
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Targeted(29)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit lethality due to placental defects. Heterozygotes show greater B cell proliferation, enhanced leptin secretion, and resistance to diet-induced adipocyte hypertrophy and insulin resistance.
 
Human Diseases Modeled Using Mouse Pparg (4)    Alleles Annotated to Human Diseases(5)    Phenotype Images(6)
Interactions
Pparg interacts with 88 markers (Mir1a-1, Mir1a-2, Mir10b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (64 records)
Data Summary: Results (226)    Tissues (161)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 162
Northern blot 31
RT-PCR 33
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(49) Genomic(7) cDNA(35) Primer pair(5) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000000440 (Evidence)
Entrez Gene19016 (Evidence)
UniGene3020
DFCITC1584275
DoTSDT.527551, DT.529203, DT.91379717
NIA Mouse Gene IndexU007293
Consensus CDS ProjectCCDS20439.1, CCDS51876.1
International Mouse Knockout Project StatusPparg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000440 Ensembl Gene Model | MGI Sequence Detail 129181 C57BL/6J ±  kb
transcript ENSMUST00000000450 Ensembl | MGI Sequence Detail 1769 Not Applicable 
polypeptide ENSMUSP00000000450 Ensembl | MGI Sequence Detail 505 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(22) UniProt(15)
Polymorphisms
RFLP(2) : SNPs within 2kb(858 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR003074 Peroxisome proliferator-activated receptor
InterPro IPR003077 Peroxisome proliferator-activated receptor, gamma
InterPro IPR022590 Peroxisome proliferator-activated receptor gamma, N-terminal
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000013058 peroxisome proliferator-activated receptor gamma
References
(Earliest) J:15412 Chen F, et al., Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem Biophys Res Commun. 1993 Oct 29;196(2):671-7
(Latest) J:213530 He H, et al., Rosiglitazone causes cardiotoxicity via peroxisome proliferator-activated receptor gamma-independent mitochondrial oxidative stress in mouse hearts. Toxicol Sci. 2014 Apr;138(2):468-81
All references(445)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-13589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory