About   Help   FAQ
Pparg Gene Detail
Summary
  • Symbol
    Pparg
  • Name
    peroxisome proliferator activated receptor gamma
  • Synonyms
    Nr1c3, PPARgamma, PPAR-gamma, Ppar-gamma2, PPARgamma2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97747
    NCBI Gene: 19016
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:115360951-115490399 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 53.41 cM, cytoband E3-F1
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    854 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97747
protein coding gene Chr6:115360877-115490404 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031148
protein coding gene Chr6:117973980-118109395 (+)
A/J MGP_AJ_G0031117
protein coding gene Chr6:113447122-113577670 (+)
AKR/J MGP_AKRJ_G0031048
protein coding gene Chr6:116504747-116637943 (+)
BALB/cJ MGP_BALBcJ_G0031128
protein coding gene Chr6:113263524-113393400 (+)
C3H/HeJ MGP_C3HHeJ_G0030580
protein coding gene Chr6:67664852-67796933 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031587
protein coding gene Chr6:120977640-121121081 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028751
protein coding gene Chr6:110463263-110593171 (+)
CAST/EiJ MGP_CASTEiJ_G0030235
protein coding gene Chr6:116860554-116993523 (+)
CBA/J MGP_CBAJ_G0030814
protein coding gene Chr6:125735533-125879183 (+)
DBA/2J MGP_DBA2J_G0030967
protein coding gene Chr6:112379775-112509424 (+)
FVB/NJ MGP_FVBNJ_G0030921
protein coding gene Chr6:111547612-111680179 (+)
LP/J MGP_LPJ_G0031047
protein coding gene Chr6:117991081-118126805 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030955
protein coding gene Chr6:129932992-130075596 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031614
protein coding gene Chr6:116514265-116646212 (+)
PWK/PhJ MGP_PWKPhJ_G0029951
protein coding gene Chr6:111379560-111509633 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029779
protein coding gene Chr6:115219709-115356776 (+)
WSB/EiJ MGP_WSBEiJ_G0030319
protein coding gene Chr6:116767854-116903332 (+)



Homology
more
  • Human Ortholog
    PPARG, peroxisome proliferator activated receptor gamma
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPARG, peroxisome proliferator activated receptor gamma
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma
  • Links
    NCBI Gene ID: 5468
    neXtProt AC: NX_P37231
    UniProt: P37231

  • Chr Location
    3p25.2; chr3:12287850-12471054 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    5 with Pparg mouse models; 2 with human PPARG associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 2 models
IDs
View 3 models
IDs
View 1 model
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    9 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    241 phenotypes from 26 alleles in 28 genetic backgrounds
    95 phenotypes from multigenic genotypes
    6 images
    236 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit lethality due to placental defects. Heterozygotes show greater B cell proliferation, enhanced leptin secretion, and resistance to diet-induced adipocyte hypertrophy and insulin resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000440 Ensembl Gene Model | MGI Sequence Detail 129449 C57BL/6J ±  kb
    transcript ENSMUST00000000450 Ensembl | MGI Sequence Detail 1767 Not Applicable  
    polypeptide ENSMUSP00000000450 Ensembl | MGI Sequence Detail 505 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000013058 peroxisome proliferator-activated receptor gamma
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR003074 Peroxisome proliferator-activated receptor
      IPR003077 Peroxisome proliferator-activated receptor gamma
      IPR022590 Peroxisome proliferator-activated receptor gamma, N-terminal
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 7
      cDNA 36
      Primer pair 9
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13589
    References
    more
    • Summaries
      All 753
      Developmental Gene Expression 90
      Diseases 8
      Gene Ontology 54
      Phenotypes 236
    • Earliest
      J:15412 Chen F, et al., Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem Biophys Res Commun. 1993 Oct 29;196(2):671-7
    • Latest
      J:267062 Karnati S, et al., PPARalpha-mediated peroxisome induction compensates PPARgamma-deficiency in bronchiolar club cells. PLoS One. 2018;13(9):e0203466

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory