Pparg
Gene Detail

Symbol Name ID

Pparg peroxisome proliferator activated receptor gamma MGI:97747

Synonyms

Nr1c3, PPARgamma, PPAR-gamma, Ppar-gamma2, PPARgamma2

Feature Type

protein coding gene

Genetic Map

Chromosome 6

53.41 cM, cytoband E3-F1
Detailed Genetic Map ± 1 cM


Mapping data(21)

Sequence Map

Chr6:115361221-115490401 bp, + strand From NCBI annotation of GRCm38   129181 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7899  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: peroxisome proliferator activated receptor (PPAR)
Gene Tree: Pparg

Human homologs

Human Homolog		PPARG, peroxisome proliferator-activated receptor gamma
NCBI Gene ID		5468
neXtProt AC		NX_P37231
Human Synonyms		CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma
Human Chr (Location)		3p25; chr3:12329349-12475855 (+)  GRCh37.p10
Disease Associations		(4) Diseases Associated with Human PPARG

Alleles and phenotypes

All alleles(29) : Targeted(29)
 

Homozygotes for targeted null mutations exhibit lethality due to placental defects. Heterozygotes show greater B cell proliferation, enhanced leptin secretion, and resistance to diet-induced adipocyte hypertrophy and insulin resistance.

 
Human Diseases Modeled Using Mouse Pparg (5)    Alleles Annotated to Human Diseases(6)    Phenotype Images(6)

Gene Ontology (GO) classifications

All GO classifications: (99 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, brown fat cell differentiation, ...
Component	cytoplasm, cytosol, ...
Function	activating transcription factor binding, arachidonic acid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (49 records)
Data Summary: Results (198)    Tissues (133)    Images (31)
Theiler Stages: 5, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	134
Northern blot	31
RT-PCR	33

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(49) Genomic(7) cDNA(35) Primer pair(5) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000000440 (Evidence)
Entrez Gene	19016 (Evidence)
UniGene	3020
DFCI	TC1584275
DoTS	DT.527551, DT.529203, DT.91379717
NIA Mouse Gene Index	U007293
Consensus CDS Project	CCDS20439.1, CCDS51876.1
International Mouse Knockout Project Status	Pparg

Sequences

Length	Strain/Species
genomic	19016	NCBI Gene Model | MGI Sequence Detail	129181	C57BL/6J
transcript	NM_001127330	RefSeq | MGI Sequence Detail	1857	C57BL/6
polypeptide	P37238	UniProt | EBI | MGI Sequence Detail	505	Not Applicable

All sequences(50) RefSeq(4) UniProt(7)

Polymorphisms

RFLP(2) : SNPs(305 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR003074	Peroxisome proliferator-activated receptor
InterPro	IPR003077	Peroxisome proliferator-activated receptor, gamma
InterPro	IPR022590	Peroxisome proliferator-activated receptor gamma, N-terminal
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000013058	peroxisome proliferator-activated receptor gamma

Graphical View of Protein Domain Structure

References

(Earliest) J:15412 Chen F, et al., Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem Biophys Res Commun. 1993 Oct 29;196(2):671-7
(Latest) J:194317 Vasheghani F, et al., Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype. Am J Pathol. 2013 Apr;182(4):1099-106
All references(391)

Other accession IDs

MGD-MRK-13589