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Pparg Gene Detail
Summary
  • Symbol
    Pparg
  • Name
    peroxisome proliferator activated receptor gamma
  • Synonyms
    Nr1c3, PPARgamma, PPAR-gamma, Ppar-gamma2, PPARgamma2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97747
    NCBI Gene: 19016
Location & Maps
more
  • Sequence Map
    Chr6:115360951-115490399 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      129449 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PPARG, peroxisome proliferator activated receptor gamma
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPARG, peroxisome proliferator activated receptor gamma
    Orthology source: HomoloGene
  • Synonyms
    CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma
  • Links
    NCBI Gene ID: 5468
    neXtProt AC: NX_P37231

  • Chr Location
    3p25; chr3:12287850-12471013 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    4 with Pparg mouse models; 3 with human PPARG associations

Human Disease Mouse Models
       Lipodystrophy, Familial Partial, Type 3; FPLD3   OMIM: 604367 View 3 models
       Lipodystrophy, Congenital Generalized, Type 2; CGL2   OMIM: 269700 View 2 models
Pulmonary Hypertension, Primary, 1; PPH1   OMIM: 178600 View 1 model
Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 1 model
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853
Obesity   OMIM: 601665
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    7 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    240 phenotypes from 25 alleles in 27 genetic backgrounds
    90 phenotypes from multigenic genotypes
    6 images
    192 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    34
  • Spontaneous
    1
  • Targeted
    31
  • Transgenic
    2
  • Genomic Mutations
    1 involving Pparg
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit lethality due to placental defects. Heterozygotes show greater B cell proliferation, enhanced leptin secretion, and resistance to diet-induced adipocyte hypertrophy and insulin resistance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056643 VEGA Gene Model | MGI Sequence Detail 129449 C57BL/6J ±  kb
transcript OTTMUST00000139814 VEGA | MGI Sequence Detail 1767 Not Applicable  
polypeptide OTTMUSP00000073339 VEGA | MGI Sequence Detail 505 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    854 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000013058 peroxisome proliferator-activated receptor gamma
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR003074 Peroxisome proliferator-activated receptor
    IPR003077 Peroxisome proliferator-activated receptor, gamma
    IPR022590 Peroxisome proliferator-activated receptor gamma, N-terminal
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 52
    Genomic 7
    cDNA 35
    Primer pair 8
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13589
References
more
  • Summaries
    All 489
    Developmental Gene Expression 69
    Diseases 7
    Gene Ontology 49
    Phenotypes 192
  • Earliest
    J:15412 Chen F, et al., Identification of two mPPAR related receptors and evidence for the existence of five subfamily members. Biochem Biophys Res Commun. 1993 Oct 29;196(2):671-7
  • Latest
    J:230921 Abd Alla J, et al., Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. J Biol Chem. 2016 Feb 5;291(6):2583-600

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory