Pparg^tm2(tTA)Yba
Targeted Allele Detail

Summary

• Symbol: Pparg^tm2(tTA)Yba
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 2, Yaacob Barak
• MGI ID: MGI:3511358
• Synonyms: Pparg^ldi, Pparg^tm2Yba
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm2(tTA)Yba page

Lipodystrophy phenotypes of Pparg^tm2(tTA)Yba/Pparg⁺ mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125992
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with an Idi cassette that contains an IRES-tTA, neo, poly-adenylation signal, TetO and flag-tagged cDNA. While expression is modest in adipose tissue, it is poor in the liver and placenta. (J:125992)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 39 strains or lines available

References

• Original: J:125992 Kim S, et al., A mouse model of conditional lipodystrophy. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16627-32
• All: 2 reference(s)