Plau
Gene Detail

Symbol Name ID

Plau plasminogen activator, urokinase MGI:97611

STS

D14Nds1

Synonyms

uPA, u-PA, urokinase-type plasminogen activator

Feature Type

protein coding gene

Genetic Map

Chromosome 14

11.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(41)

Sequence Map

Chr14:20836662-20843388 bp, + strand From NCBI annotation of GRCm38   6727 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55670  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: urokinase-type plasminogen activator
Gene Tree: Plau

Human homologs

Human Homolog		PLAU, plasminogen activator, urokinase
NCBI Gene ID		5328
neXtProt AC		NX_P00749
Human Synonyms		ATF, BDPLT5, QPD, u-PA, UPA, URK
Human Chr (Location)		10q22.2; chr10:75670862-75677259 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PLAU

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygotes show occasional fibrin deposits in non-healing ulcerations and reduced neointima formation after arterial injury. They are susceptible to thrombosis after traumatic or inflammatory challenge and appear to be immunologically hyporesponsive displaying characteristics of functional anergy.

 
Human Diseases Modeled Using Mouse Plau (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	angiogenesis, fibrinolysis, ...
Component	cell surface, extracellular region, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (188)    Tissues (158)    Images (31)
Theiler Stages: 1, 2, 3, 4, 7, 9, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	151
Northern blot	11
RT-PCR	21

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(14) Primer pair(8) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000021822 (Evidence)
Entrez Gene	18792 (Evidence)
UniGene	4183
DFCI	TC1587755
DoTS	DT.87035702
NIA Mouse Gene Index	U015369
EC	3.4.21.73
PDB	3LAQ
Consensus CDS Project	CCDS26858.1
International Mouse Knockout Project Status	Plau

Sequences

Length	Strain/Species
genomic	18792	NCBI Gene Model | MGI Sequence Detail	6727	C57BL/6J
transcript	NM_008873	RefSeq | MGI Sequence Detail	2343	Not Specified
polypeptide	P06869	UniProt | EBI | MGI Sequence Detail	433	Not Applicable

All sequences(18) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(14) : PCR(7) RFLP(7) SNPs(48 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR000001	Kringle
InterPro	IPR018056	Kringle, conserved site
InterPro	IPR013806	Kringle-like fold
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
Protein Ontology	PR:000012826	urokinase-type plasminogen activator

Graphical View of Protein Domain Structure

References

(Earliest) J:7809 Belin D, et al., Cloning, nucleotide sequencing and expression of cDNAs encoding mouse urokinase-type plasminogen activator. Eur J Biochem. 1985 Apr 15;148(2):225-32
(Latest) J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
All references(206)

Other accession IDs

MGD-MRK-13347