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Plau Gene Detail
Summary
  • Symbol
    Plau
  • Name
    plasminogen activator, urokinase
  • Synonyms
    uPA, u-PA, urokinase-type plasminogen activator
  • Feature Type
    protein coding gene
  • IDs
    MGI:97611
    NCBI Gene: 18792
  • Gene Overview
    MyGene.info: PLAU
Location & Maps
more
  • Sequence Map
    Chr14:20836662-20843388 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6727 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    41 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    PLAU, plasminogen activator, urokinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLAU, plasminogen activator, urokinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATF, BDPLT5, QPD, u-PA, UPA, URK
  • Links
    NCBI Gene ID: 5328
    neXtProt AC: NX_P00749

  • Chr Location
    10q22.2; chr10:73909182-73917501 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with Plau mouse models; 2 with human PLAU associations

Human Disease Mouse Models
       Alzheimer Disease; AD   OMIM: 104300 View 1 model
       Fatty Liver Disease, Nonalcoholic, Susceptibility to, 1; NAFLD1   OMIM: 613282 View 1 model
Hepatocellular Carcinoma   OMIM: 114550 View 1 model
       Quebec Platelet Disorder; QPD   OMIM: 601709
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    74 phenotypes from 4 alleles in 8 genetic backgrounds
    28 phenotypes from multigenic genotypes
    139 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Targeted
    7
  • Transgenic
    5
  • Incidental Mutations
Homozygotes show occasional fibrin deposits in non-healing ulcerations and reduced neointima formation after arterial injury. They are susceptible to thrombosis after traumatic or inflammatory challenge and appear to be immunologically hyporesponsive displaying characteristics of functional anergy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18792 NCBI Gene Model | MGI Sequence Detail 6727 C57BL/6J ±  kb
transcript NM_008873 RefSeq | MGI Sequence Detail 2343 Not Specified  
polypeptide P06869 UniProt | EBI | MGI Sequence Detail 433 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    52 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 15
    Primer pair 8
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13347
References
more
  • Summaries
    All 219
    Developmental Gene Expression 26
    Diseases 4
    Gene Ontology 8
    Phenotypes 139
  • Earliest
    J:7809 Belin D, et al., Cloning, nucleotide sequencing and expression of cDNAs encoding mouse urokinase-type plasminogen activator. Eur J Biochem. 1985 Apr 15;148(2):225-32
  • Latest
    J:232502 Motley MP, et al., A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo. Blood. 2016 Mar 3;127(9):1085-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory