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Plau
Gene Detail
Symbol

Name
ID
Plau
plasminogen activator, urokinase
MGI:97611
STS
Synonyms
uPA, u-PA, urokinase-type plasminogen activator
Feature Type
protein coding gene
Genetic Map
Chromosome 14
11.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(41)
Sequence Map
Chr14:20836662-20843388 bp, + strand
From NCBI annotation of GRCm38

  6727 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55670  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: PLAU
Protein SuperFamily: urokinase-type plasminogen activator
Gene Tree: Plau

Human
homologs
PLAU, plasminogen activator, urokinase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5328
neXtProt AC: NX_P00749

Human Synonyms: ATF, BDPLT5, QPD, u-PA, UPA, URK

Human Chr (Location): 10q22.2; chr10:73909182-73917501 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human PLAU

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes show occasional fibrin deposits in non-healing ulcerations and reduced neointima formation after arterial injury. They are susceptible to thrombosis after traumatic or inflammatory challenge and appear to be immunologically hyporesponsive displaying characteristics of functional anergy.
 
Human Diseases Modeled in Mice Using Plau (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Plau interacts with 158 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process angiogenesis, fibrinolysis, ...
Component cell surface, extracellular exosome, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (242)    Tissues (212)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 208
Northern blot 11
RT-PCR 18
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(14) Primer pair(8) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000021822 (Evidence)
Entrez Gene 18792 (Evidence)
UniGene 4183
DFCI TC1587755
DoTS DT.87035702
NIA Mouse Gene Index U015369
EC 3.4.21.73
PDB 3LAQ
Consensus CDS Project CCDS26858.1
International Mouse Phenotyping Consortium Status Plau
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18792 NCBI Gene Model | MGI Sequence Detail 6727 C57BL/6J ±  kb
transcript NM_008873 RefSeq | MGI Sequence Detail 2343 Not Specified 
polypeptide P06869 UniProt | EBI | MGI Sequence Detail 433 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(14) : PCR(7) RFLP(7) SNPs within 2kb(56 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000012826 urokinase-type plasminogen activator
Graphical View of Protein Domain Structure
References
(Earliest) J:7809 Belin D, et al., Cloning, nucleotide sequencing and expression of cDNAs encoding mouse urokinase-type plasminogen activator. Eur J Biochem. 1985 Apr 15;148(2):225-32
(Latest) J:216959 Marudamuthu AS, et al., Role of the Urokinase-Fibrinolytic System in Epithelial-Mesenchymal Transition during Lung Injury. Am J Pathol. 2015 Jan;185(1):55-68
All references(212)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13347

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory