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Abcb1a
Gene Detail
Symbol

Name
ID
Abcb1a
ATP-binding cassette, sub-family B (MDR/TAP), member 1A
MGI:97570
STS
Synonyms
Evi32, Mdr1a, mdr-3, MDR3, multiple drug resistant 1a, P-glycoprotein, Pgp, P-gp, Pgy3, Pgy-3
Feature Type
protein coding gene
Genetic Map
Chromosome 5
3.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:8660077-8748575 bp, + strand
From VEGA annotation of GRCm38

  88499 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55496  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: ABCB1
Gene Tree: Abcb1a

Human
homologs
ABCB1, ATP-binding cassette, sub-family B (MDR/TAP), member 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5243
neXtProt AC: NX_P08183

Human Synonyms: ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1

Human Chr (Location): 7q21.12; chr7:87503863-87713323 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ABCB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Spontaneous(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutations in this gene result in increased sensitivity to various drugs, including avermectins and vinblastine.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Abcb1a interacts with 219 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process daunorubicin transport, drug export, ...
Component apical part of cell, cell surface, ...
Function ATPase activity, ATPase activity, coupled, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (209)    Tissues (172)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 139
Northern blot 18
Western blot 2
RT-PCR 50
cDNA source data(32)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(7) cDNA(38) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000029053 (Evidence)
Ensembl Gene Model ENSMUSG00000040584 (Evidence)
Entrez Gene 18671 (Evidence)
UniGene 207354
DFCI TC1583894
DoTS DT.492420, DT.97382679
NIA Mouse Gene Index U025903
EC 3.6.3.44
PDB 3G5U, 4KSB, 4KSC, 4KSD, 4LSG, 4M1M, 4M2S, 4M2T, 4Q9H, 4Q9I, 4Q9J, 4Q9K, 4Q9L, 3G60, 3G61
Consensus CDS Project CCDS19084.1
International Mouse Phenotyping Consortium Status Abcb1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029053 VEGA Gene Model | MGI Sequence Detail 88499 C57BL/6J ±  kb
transcript OTTMUST00000072084 VEGA | MGI Sequence Detail 4997 Not Applicable 
polypeptide OTTMUSP00000037023 VEGA | MGI Sequence Detail 1276 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(848 from dbSNP Build 137)    SNPs within 2kb including multiple locations(916)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR017871 ABC transporter, conserved site
InterPro IPR003439 ABC transporter-like
InterPro IPR011527 ABC transporter, transmembrane domain, type 1
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000001891 multidrug resistance protein 1
References
(Earliest) J:8447 Gros P, et al., Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell. 1986 Nov 7;47(3):371-80
(Latest) J:211972 Chuan Tang S, et al., Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar. Int J Cancer. 2014 Mar 15;134(6):1484-94
All references(173)
Other
accession IDs
MGD-MRK-13285, MGD-MRK-13288, MGI:1928146

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory