Abcb1a
Gene Detail

Symbol Name ID

Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A MGI:97570

STS

D5Mit47

Synonyms

Evi32, Mdr1a, mdr-3, MDR3, multiple drug resistant 1a, P-glycoprotein, Pgp, P-gp, Pgy3, Pgy-3

Feature Type

protein coding gene

Genetic Map

Chromosome 5

3.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:8660077-8748575 bp, + strand From VEGA annotation of GRCm38   88499 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55496  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

Protein SuperFamily: multidrug resistance protein
Gene Tree: Abcb1a

Human homologs

Human Homolog		ABCB1, ATP-binding cassette, sub-family B (MDR/TAP), member 1
NCBI Gene ID		5243
neXtProt AC		NX_P08183
Human Synonyms		ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Human Chr (Location)		7q21.12; chr7:87133179-87342639 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ABCB1

Alleles and phenotypes

All alleles(10) : Targeted(3) Gene trapped(6) Spontaneous(1)
 

Mutations in this gene result in increased sensitivity to various drugs, including avermectins and vinblastine.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	ATP catabolic process, drug transmembrane transport, ...
Component	apical plasma membrane, cell surface, ...
Function	ATPase activity, ATPase activity, coupled, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (209)    Tissues (172)    Images (15)
Theiler Stages: 2, 5, 10, 14, 19, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	139
Northern blot	18
Western blot	2
RT-PCR	50

cDNA source data(32)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(47) Genomic(7) cDNA(38) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000029053 (Evidence)
Ensembl Gene Model	ENSMUSG00000040584 (Evidence)
Entrez Gene	18671 (Evidence)
UniGene	207354
DFCI	TC1583894
DoTS	DT.492420, DT.97382679
NIA Mouse Gene Index	U025903
EC	3.6.3.44
PDB	3G5U, 3G60, 3G61
Consensus CDS Project	CCDS19084.1
International Mouse Knockout Project Status	Abcb1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029053	VEGA Gene Model | MGI Sequence Detail	88499	C57BL/6J
transcript	OTTMUST00000072084	VEGA | MGI Sequence Detail	4997	Not Applicable
polypeptide	OTTMUSP00000037023	VEGA | MGI Sequence Detail	1276	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(471 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR017871	ABC transporter, conserved site
InterPro	IPR017940	ABC transporter, integral membrane type 1
InterPro	IPR003439	ABC transporter-like
InterPro	IPR001140	ABC transporter, transmembrane domain
InterPro	IPR011527	ABC transporter, transmembrane domain, type 1
Protein Ontology	PR:000001891	multidrug resistance protein 1

References

(Earliest) J:8447 Gros P, et al., Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell. 1986 Nov 7;47(3):371-80
(Latest) J:193631 Jaspers JE, et al., Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov. 2013 Jan;3(1):68-81
All references(169)

Other accession IDs

MGD-MRK-13285, MGD-MRK-13288, MGI:1928146