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Abcb1a Gene Detail
Summary
  • Symbol
    Abcb1a
  • Name
    ATP-binding cassette, sub-family B (MDR/TAP), member 1A
  • Synonyms
    Evi32, Mdr1a, mdr-3, MDR3, multiple drug resistant 1a, P-glycoprotein, Pgp, P-gp, Pgy3, Pgy-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97570
    NCBI Gene: 18671
  • Gene Overview
    MyGene.info: ABCB1
Location & Maps
more
  • Genetic Map
    Chromosome 5, 3.43 cM
  • Mapping Data
    2 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    ABCB1, ATP binding cassette subfamily B member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ABCB1, ATP binding cassette subfamily B member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
  • Links
    NCBI Gene ID: 5243
    neXtProt AC: NX_P08183

  • Chr Location
    7q21.12; chr7:87503863-87713323 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Abcb1a mouse models; 2 with human ABCB1 associations

Human Disease Mouse Models
       Inflammatory Bowel Disease 13; IBD13   OMIM: 612244 View 1 model
       Colchicine Resistance   OMIM: 120080
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 2 alleles in 4 genetic backgrounds
    12 phenotypes from multigenic genotypes
    1 images
    94 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    6
  • Spontaneous
    1
  • Targeted
    3
  • Incidental Mutations
Mutations in this gene result in increased sensitivity to various drugs, including avermectins and vinblastine. Mice with a null allele develop spontanous colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029053 VEGA Gene Model | MGI Sequence Detail 88499 C57BL/6J ±  kb
transcript OTTMUST00000072084 VEGA | MGI Sequence Detail 4997 Not Applicable  
polypeptide OTTMUSP00000037023 VEGA | MGI Sequence Detail 1276 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1415 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 47
    Genomic 7
    cDNA 38
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-13285, MGD-MRK-13288, MGI:1928146
References
more
  • Summaries
    All 179
    Developmental Gene Expression 12
    Diseases 4
    Gene Ontology 9
    Phenotypes 94
  • Earliest
    J:8447 Gros P, et al., Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell. 1986 Nov 7;47(3):371-80
  • Latest
    J:231825 Phoenix TN, et al., Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype. Cancer Cell. 2016 Apr 11;29(4):508-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory