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Abcb1a Gene Detail
Summary
  • Symbol
    Abcb1a
  • Name
    ATP-binding cassette, sub-family B (MDR/TAP), member 1A
  • Synonyms
    Evi32, Mdr1a, mdr-3, MDR3, multiple drug resistant 1a, P-glycoprotein, Pgp, P-gp, Pgy3, Pgy-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:97570
    NCBI Gene: 18671
  • Gene Overview
    MyGene.info: ABCB1
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 5, 3.43 cM
  • Mapping Data
    2 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    ABCB1, ATP binding cassette subfamily B member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ABCB1, ATP binding cassette subfamily B member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
  • Links
    NCBI Gene ID: 5243
    neXtProt AC: NX_P08183
    UniProt: P08183

  • Chr Location
    7q21.12; chr7:87503863-87713323 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Abcb1a mouse models; 1 with human ABCB1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 2 alleles in 4 genetic backgrounds
    12 phenotypes from multigenic genotypes
    1 images
    102 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene result in increased sensitivity to various drugs, including avermectins and vinblastine. Mice with a null allele develop spontanous colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000029053 VEGA Gene Model | MGI Sequence Detail 88499 C57BL/6J ±  kb
    transcript OTTMUST00000072084 VEGA | MGI Sequence Detail 4997 Not Applicable  
    polypeptide OTTMUSP00000037023 VEGA | MGI Sequence Detail 1276 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      1415 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 7
      cDNA 39
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13285, MGD-MRK-13288, MGI:1928146
    References
    more
    • Summaries
      All 195
      Developmental Gene Expression 12
      Diseases 2
      Gene Ontology 8
      Phenotypes 102
    • Earliest
      J:8447 Gros P, et al., Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell. 1986 Nov 7;47(3):371-80
    • Latest
      J:257414 Sason H, et al., Asc-1 Transporter Regulation of Synaptic Activity via the Tonic Release of d-Serine in the Forebrain. Cereb Cortex. 2017 Feb 1;27(2):1573-1587

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory