Abcb4
Gene Detail

Symbol Name ID

Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 MGI:97569

STS

D5Mit47

Synonyms

mdr-2, Mdr2, Pgy2, Pgy-2

Feature Type

protein coding gene

Genetic Map

Chromosome 5

3.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:8893721-8959225 bp, + strand From Ensembl annotation of GRCm38   65505 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:113698  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: multidrug resistance protein
Gene Tree: Abcb4

Human homologs

Human Homolog		ABCB4, ATP-binding cassette, sub-family B (MDR/TAP), member 4
NCBI Gene ID		5244
neXtProt AC		NX_P21439
Human Synonyms		ABC21, GBD1, ICP3, MDR2, MDR2/3, MDR3, PFIC-3, PGY3
Human Chr (Location)		7q21.1; chr7:87031361-87105019 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human ABCB4

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for targeted mutations that inactivate the gene are unable to secrete phospholipids into bile, leading to progressive hepatic disease, with an end stage of 3 months.

 
Human Diseases Modeled Using Mouse Abcb4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	ATP catabolic process, drug transmembrane transport, ...
Component	apical plasma membrane, Golgi membrane, ...
Function	ATPase activity, ATPase activity, coupled to transmembrane movement of substances, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (99)    Tissues (99)    Images (2)
Theiler Stages: 2, 5, 10, 14, 22, 28

Assay Type	Results
RNA in situ	94
Northern blot	1
RT-PCR	4

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) Genomic(5) cDNA(31) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000042476 (Evidence)
Entrez Gene	18670 (Evidence)
UniGene	297825
DFCI	TC1585725, TC1684699
DoTS	DT.101325359, DT.101338403, DT.40158266, DT.97387414
NIA Mouse Gene Index	U025901
EC	3.6.3.44
Consensus CDS Project	CCDS19086.1
International Mouse Knockout Project Status	Abcb4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000042476	Ensembl Gene Model | MGI Sequence Detail	65505	C57BL/6J
transcript	ENSMUST00000003717	Ensembl | MGI Sequence Detail	4074	Not Applicable
polypeptide	ENSMUSP00000003717	Ensembl | MGI Sequence Detail	1276	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(753 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003593	AAA+ ATPase domain
InterPro	IPR017871	ABC transporter, conserved site
InterPro	IPR017940	ABC transporter, integral membrane type 1
InterPro	IPR003439	ABC transporter-like
InterPro	IPR001140	ABC transporter, transmembrane domain
InterPro	IPR011527	ABC transporter, transmembrane domain, type 1
Protein Ontology	PR:000031831	multidrug resistance protein 3

References

(Earliest) J:8447 Gros P, et al., Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell. 1986 Nov 7;47(3):371-80
(Latest) J:194005 Singer S, et al., Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes. Mol Cell. 2012 Dec 14;48(5):799-810
All references(109)

Other accession IDs

MGD-MRK-13284, MGD-MRK-13287