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Abcb4tm1Bor
Targeted Allele Detail
Summary
Symbol: Abcb4tm1Bor
Name: ATP-binding cassette, sub-family B member 4; targeted mutation 1, Piet Borst
MGI ID: MGI:1857236
Synonyms: mdr2-, Mdr2ko, mdr2neo1, Pgy2tm1Bor
Gene: Abcb4  Location: Chr5:8943717-9009231 bp, + strand  Genetic Position: Chr5, 3.43 cM
Alliance: Abcb4tm1Bor page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:15531
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exons 1 and 2. The translation initiation site is in exon 2. RNase proteiction assays indicated that mutant truncated transcripts are produced from this allele that contain exons 3-6 or 4-6. (J:15531)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 8 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 13 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Abcb4tm1Bor
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abcb4 Mutation:  66 strains or lines available
References
Original:  J:15531 Smit JJ, et al., Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell. 1993 Nov 5;75(3):451-62
All:  135 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/01/2024
MGI 6.24
The Jackson Laboratory