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Notch2 Gene Detail
Summary
  • Symbol
    Notch2
  • Name
    notch 2
  • Synonyms
    Motch B, N2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97364
    NCBI Gene: 18129
  • Gene Overview
    MyGene.info: NOTCH2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:98013538-98150367 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 42.42 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1098 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97364
protein coding gene Chr3:98013527-98150367 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027647
protein coding gene Chr3:98995089-99135666 (+)
A/J MGP_AJ_G0027609
protein coding gene Chr3:95818356-95956393 (+)
AKR/J MGP_AKRJ_G0027576
protein coding gene Chr3:98114708-98253006 (+)
BALB/cJ MGP_BALBcJ_G0027619
protein coding gene Chr3:95622169-95759999 (+)
C3H/HeJ MGP_C3HHeJ_G0027351
protein coding gene Chr3:98379714-98516126 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028065
protein coding gene Chr3:102666486-102809405 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025407
protein coding gene Chr3:92074117-92210420 (+)
CAST/EiJ MGP_CASTEiJ_G0026806
protein coding gene Chr3:97678842-97824110 (+)
CBA/J MGP_CBAJ_G0027326
protein coding gene Chr3:106328161-106475418 (+)
DBA/2J MGP_DBA2J_G0027469
protein coding gene Chr3:95130611-95267484 (+)
FVB/NJ MGP_FVBNJ_G0027438
protein coding gene Chr3:93121957-93261024 (+)
LP/J MGP_LPJ_G0027574
protein coding gene Chr3:100257334-100399814 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027464
protein coding gene Chr3:112399698-112543392 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028119
protein coding gene Chr3:97739282-97880506 (+)
PWK/PhJ MGP_PWKPhJ_G0026531
protein coding gene Chr3:95023478-95162790 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026353
protein coding gene Chr3:96014908-96153001 (+)
WSB/EiJ MGP_WSBEiJ_G0026884
protein coding gene Chr3:98176643-98318321 (+)



Homology
more
  • Human Ortholog
    NOTCH2, notch 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NOTCH2, notch 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGS2, HJCYS, hN2
  • Links
    NCBI Gene ID: 4853
    neXtProt AC: NX_Q04721
    UniProt: Q04721

  • Chr Location
    1p12; chr1:119911553-120073449 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Notch2 mouse models; 2 with human NOTCH2 associations

Human Disease Mouse Models
      
IDs
View 3 models
      
IDs
View 1 model
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    143 phenotypes from 17 alleles in 23 genetic backgrounds
    60 phenotypes from multigenic genotypes
    145 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for null alleles exhibit defects in embryonic development resulting in embryonic or neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18129 NCBI Gene Model | MGI Sequence Detail 136830 C57BL/6J ±  kb
    transcript NM_010928 RefSeq | MGI Sequence Detail 10506 C57BL/6  
    polypeptide O35516 UniProt | EBI | MGI Sequence Detail 2470 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 24
      Primer pair 9
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12916, MGI:2139830
    References
    more
    • Summaries
      All 396
      Developmental Gene Expression 210
      Diseases 5
      Gene Ontology 22
      Phenotypes 145
    • Earliest
      J:34445 Weinmaster G, et al., Notch2: a second mammalian Notch gene. Development. 1992 Dec;116(4):931-41
    • Latest
      J:266199 Huang S, et al., Jagged1/Notch2 controls kidney fibrosis via Tfam-mediated metabolic reprogramming. PLoS Biol. 2018 Sep;16(9):e2005233

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory