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Gene Detail
notch 2
Synonyms Motch B, N2
Feature Type protein coding gene
Genetic Map
Chromosome 3
42.42 cM
Detailed Genetic Map ± 1 cM

Mapping data(3)
Sequence Map
Chr3:98013538-98150367 bp, + strand
From NCBI annotation of GRCm38

  136830 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:7865  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: notch protein
Gene Tree: Notch2

Human Homolog NOTCH2, notch 2
NCBI Gene ID 4853
neXtProt AC  NX_Q04721
Human Synonyms  AGS2, HJCYS, hN2
Human Chr (Location)  1p13-p11; chr1:119911553-120100748 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human NOTCH2
alleles, and
All mutations/alleles(33) : Gene trapped(17) Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for null alleles exhibit defects in embryonic development resulting in embryonic or neonatal lethality.
Human Diseases Modeled Using Mouse Notch2 (1)    Alleles Annotated to Human Diseases(2)   
Notch2 interacts with 381 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
All GO classifications: (57 annotations)
Process atrial septum morphogenesis, bone remodeling, ...
Component cell, cell surface, ...
Function calcium ion binding, enzyme binding, ...
External Resources: FuncBase
Literature Summary: (166 records)
Data Summary: Results (981)    Tissues (250)    Images (102)
Theiler Stages: 1, 2, 3, 5, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 744
In situ reporter (knock in) 23
Northern blot 6
RT-PCR 205
cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(31) Genomic(1) cDNA(21) Primer pair(8) Other(1)
Microarray probesets(5)
Other database
Ensembl Gene ModelENSMUSG00000027878 (Evidence)
Entrez Gene18129 (Evidence)
DoTSDT.111042104, DT.99853173
NIA Mouse Gene IndexU003621
Consensus CDS ProjectCCDS51013.1
International Mouse Knockout Project StatusNotch2
Representative SequencesLengthStrain/SpeciesFlank
genomic 18129 NCBI Gene Model | MGI Sequence Detail 136830 C57BL/6J ±  kb
transcript NM_010928 RefSeq | MGI Sequence Detail 10506 C57BL/6 
polypeptide O35516 UniProt | EBI | MGI Sequence Detail 2470 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(1099 from dbSNP Build 137)
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR024600 Domain of unknown function DUF3454, notch
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR022336 Neurogenic locus Notch 2
InterPro IPR008297 Notch
InterPro IPR000800 Notch domain
InterPro IPR010660 Notch, NOD domain
InterPro IPR011656 Notch, NODP domain
Protein Ontology PR:000011332 neurogenic locus notch homolog protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:34445 Weinmaster G, et al., Notch2: a second mammalian Notch gene. Development. 1992 Dec;116(4):931-41
(Latest) J:208857 Ishifune C, et al., Differentiation of CD11c+CX3CR1+ cells in the small intestine requires Notch signaling. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5986-91
All references(290)
Disease annotation references (1)
accession IDs
MGD-MRK-12916, MGI:2139830

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory