Notch2
Gene Detail

Symbol Name ID

Notch2 notch 2 MGI:97364

Synonyms

Motch B, N2

Feature Type

protein coding gene

Genetic Map

Chromosome 3

42.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:98013538-98150367 bp, + strand From NCBI annotation of GRCm38   136830 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7865  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: notch protein
Gene Tree: Notch2

Human homologs

Human Homolog		NOTCH2, notch 2
NCBI Gene ID		4853
neXtProt AC		NX_Q04721
Human Synonyms		AGS2, HJCYS, hN2
Human Chr (Location)		1p13-p11; chr1:120454176-120612317 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human NOTCH2

Alleles and phenotypes

All alleles(31) : Targeted(14) Gene trapped(17)
 

Homozygotes for null alleles exhibit defects in embryonic development resulting in embryonic or neonatal lethality.

 
Human Diseases Modeled Using Mouse Notch2 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (48 annotations)

Process	atrial septum morphogenesis, bone remodeling, ...
Component	cell surface, integral to membrane, ...
Function	calcium ion binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (153 records)
Data Summary: Results (983)    Tissues (246)    Images (102)
Theiler Stages: 1, 2, 3, 4, 5, 10, 11, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	744
In situ reporter (knock in)	23
Northern blot	6
RT-PCR	207

cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(31) Genomic(1) cDNA(21) Primer pair(8) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000027878 (Evidence)
Entrez Gene	18129 (Evidence)
DoTS	DT.111042104, DT.99853173
NIA Mouse Gene Index	U003621
Consensus CDS Project	CCDS51013.1
International Mouse Knockout Project Status	Notch2

Sequences

Length	Strain/Species
genomic	18129	NCBI Gene Model | MGI Sequence Detail	136830	C57BL/6J
transcript	NM_010928	RefSeq | MGI Sequence Detail	10506	C57BL/6
polypeptide	O35516	UniProt | EBI | MGI Sequence Detail	2470	Not Applicable

All sequences(25) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(713 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR024600	Domain of unknown function DUF3454, notch
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR022336	Neurogenic locus Notch 2
InterPro	IPR008297	Notch
InterPro	IPR000800	Notch domain
InterPro	IPR010660	Notch, NOD domain
InterPro	IPR011656	Notch, NODP domain
Protein Ontology	PR:000011332	neurogenic locus notch protein 2

Graphical View of Protein Domain Structure

References

(Earliest) J:34445 Weinmaster G, et al., Notch2: a second mammalian Notch gene. Development. 1992 Dec;116(4):931-41
(Latest) J:194597 Zanotti S, et al., Notch suppresses nuclear factor of activated T cells (NFAT) transactivation and Nfatc1 expression in chondrocytes. Endocrinology. 2013 Feb;154(2):762-72
All references(258)

Other accession IDs

MGD-MRK-12916, MGI:2139830