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Notch2 Gene Detail
Summary
  • Symbol
    Notch2
  • Name
    notch 2
  • Synonyms
    Motch B, N2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97364
    NCBI Gene: 18129
  • Gene Overview
    MyGene.info: NOTCH2
Location & Maps
more
  • Sequence Map
    Chr3:98013527-98150361 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      136835 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 42.42 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NOTCH2, notch 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NOTCH2, notch 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGS2, HJCYS, hN2
  • Links
    NCBI Gene ID: 4853
    neXtProt AC: NX_Q04721
    UniProt: Q04721

  • Chr Location
    1p12; chr1:119911553-120073449 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Notch2 mouse models; 2 with human NOTCH2 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    136 phenotypes from 15 alleles in 20 genetic backgrounds
    60 phenotypes from multigenic genotypes
    118 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null alleles exhibit defects in embryonic development resulting in embryonic or neonatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053240 VEGA Gene Model | MGI Sequence Detail 136835 C57BL/6J ±  kb
transcript OTTMUST00000132998 VEGA | MGI Sequence Detail 10500 Not Applicable  
polypeptide OTTMUSP00000070816 VEGA | MGI Sequence Detail 2473 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1098 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 32
    Genomic 1
    cDNA 21
    Primer pair 9
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12916, MGI:2139830
References
more
  • Summaries
    All 332
    Developmental Gene Expression 189
    Diseases 3
    Gene Ontology 22
    Phenotypes 118
  • Earliest
    J:34445 Weinmaster G, et al., Notch2: a second mammalian Notch gene. Development. 1992 Dec;116(4):931-41
  • Latest
    J:237537 Liu C, et al., Mapping lineage progression of somatic progenitor cells in the mouse fetal testis. Development. 2016 Oct 15;143(20):3700-3710

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory