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Notch1
Gene Detail
Symbol

Name
ID
Notch1
notch 1
MGI:97363
Synonyms
9930111A19Rik, lin-12, Mis6, Motch A, N1, Tan1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
18.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(19)
Sequence Map
Chr2:26457903-26516663 bp, - strand
From VEGA annotation of GRCm38

  58761 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32049  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NOTCH1
Protein SuperFamily: notch protein
Gene Tree: Notch1

Human
homologs
NOTCH1, notch 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4851
neXtProt AC: NX_P46531

Human Synonyms: AOS5, AOVD1, hN1, TAN1

Human Chr (Location): 9q34.3; chr9:136494444-136545786 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human NOTCH1

Mutations,
alleles, and
phenotypes
All mutations/alleles(55) : Chemically induced (ENU)(1) Gene trapped(26) Targeted(25) Transgenic(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for null alleles exhibit defects in embryonic development resulting in lethality at some point in organogenesis. Lethal phenotype may be affected by genetic background.
 
Interactions
Notch1 interacts with 304 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (218 annotations)
Process anagen, angiogenesis, ...
Component acrosomal vesicle, cell, ...
Function calcium ion binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (437 records)
Data Summary: Results (832)    Tissues (361)    Images (232)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 26
RNA in situ 619
Northern blot 30
Western blot 9
RT-PCR 127
RNase protection 21
cDNA source data(167)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NOTCH1 ; Xenbase notch1 ; ZFIN notch1a, notch1b    NEW 
Molecular
reagents
All nucleic(196) Genomic(5) cDNA(175) Primer pair(15) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000012795 (Evidence)
Ensembl Gene Model ENSMUSG00000026923 (Evidence)
Entrez Gene 18128 (Evidence)
UniGene 290610
PDB 1YMP, 2RQZ, 3P3N, 3P3P, 2QC9, 2RR0, 2RR2
Consensus CDS Project CCDS15806.1
International Mouse Phenotyping Consortium Status Notch1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012795 VEGA Gene Model | MGI Sequence Detail 58761 C57BL/6J ±  kb
transcript OTTMUST00000030656 VEGA | MGI Sequence Detail 9488 Not Applicable 
polypeptide OTTMUSP00000013754 VEGA | MGI Sequence Detail 2531 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(5) : SNPs within 2kb(372 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR024600 Domain of unknown function DUF3454, notch
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR022362 Neurogenic locus Notch 1
InterPro IPR008297 Notch
InterPro IPR000800 Notch domain
InterPro IPR010660 Notch, NOD domain
InterPro IPR011656 Notch, NODP domain
Protein Ontology PR:000011331 neurogenic locus notch homolog protein 1
References
(Earliest) J:31835 Weinmaster G, et al., A homolog of Drosophila Notch expressed during mammalian development. Development. 1991 Sep;113(1):199-205
(Latest) J:221164 Di Giovanni V, et al., Fibroblast growth factor receptor-Frs2alpha signaling is critical for nephron progenitors. Dev Biol. 2015 Apr 1;400(1):82-93
All references(769)
Other
accession IDs
MGD-MRK-12915, MGD-MRK-18791, MGI:1915375

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory