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Gene Detail
notch 1
Synonyms 9930111A19Rik, lin-12, Mis6, Motch A, N1, Tan1
Feature Type protein coding gene
Genetic Map
Chromosome 2
18.91 cM
Detailed Genetic Map ± 1 cM

Mapping data(19)
Sequence Map
Chr2:26457903-26516663 bp, - strand
From VEGA annotation of GRCm38

  58761 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:32049  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: notch protein
Gene Tree: Notch1

Human Homolog NOTCH1, notch 1
NCBI Gene ID 4851
neXtProt AC  NX_P46531
Human Synonyms  hN1, TAN1
Human Chr (Location)  9q34.3; chr9:136494444-136545786 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NOTCH1
alleles, and
All mutations/alleles(45) : Chemically induced (ENU)(1) Gene trapped(26) Targeted(18)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for null alleles exhibit defects in embryonic development resulting in lethality at some point in organogenesis. Lethal phenotype may be affected by genetic background.
Notch1 interacts with 305 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (206 annotations)
Process anagen, angiogenesis, ...
Component acrosomal vesicle, cell, ...
Function calcium ion binding, chromatin binding, ...
External Resources: FuncBase
Literature Summary: (403 records)
Data Summary: Results (821)    Tissues (354)    Images (229)
Theiler Stages: 1, 2, 3, 4, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 26
RNA in situ 608
Northern blot 30
Western blot 9
RT-PCR 127
RNase protection 21
cDNA source data(166)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(195) Genomic(5) cDNA(174) Primer pair(15) Other(1)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000012795 (Evidence)
Ensembl Gene ModelENSMUSG00000026923 (Evidence)
Entrez Gene18128 (Evidence)
PDB1YMP, 2RQZ, 3P3N, 3P3P, 2QC9, 2RR0, 2RR2
Consensus CDS ProjectCCDS15806.1
International Mouse Knockout Project StatusNotch1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012795 VEGA Gene Model | MGI Sequence Detail 58761 C57BL/6J ±  kb
transcript OTTMUST00000030656 VEGA | MGI Sequence Detail 9488 Not Applicable 
polypeptide OTTMUSP00000013754 VEGA | MGI Sequence Detail 2531 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(2) UniProt(3)
Polymorphisms RFLP(5) : SNPs within 2kb(372 from dbSNP Build 137)
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR024600 Domain of unknown function DUF3454, notch
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR022362 Neurogenic locus Notch 1
InterPro IPR008297 Notch
InterPro IPR000800 Notch domain
InterPro IPR010660 Notch, NOD domain
InterPro IPR011656 Notch, NODP domain
Protein Ontology PR:000011331 neurogenic locus notch homolog protein 1
References (Earliest) J:31835 Weinmaster G, et al., A homolog of Drosophila Notch expressed during mammalian development. Development. 1991 Sep;113(1):199-205
(Latest) J:211478 Zhang K, et al., Notch1 mediates postnatal neurogenesis in hippocampus enhanced by intermittent hypoxia. Neurobiol Dis. 2014 Apr;64:66-78
All references(725)
accession IDs
MGD-MRK-12915, MGD-MRK-18791, MGI:1915375

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory