Symbol
Name
ID

Notch1
notch 1
MGI:97363

Phenotype annotations related to embryo

Darker colors indicate more annotations

Human Phenotypes	Oligohydramnios	Decreased fetal movement
Disease(s) Associated with NOTCH1	Oligohydramnios	Decreased fetal movement
Adams-Oliver syndrome

Mouse Phenotypes

abnormal placenta vasculature

abnormal placental labyrinth vasculature morphology

abnormal vitelline vasculature morphology

absent vitelline blood vessels

small pharyngeal arch

incomplete embryo turning

abnormal left-right axis symmetry of the somites

abnormal rostral-caudal axis patterning

embryonic growth arrest

embryonic growth retardation

decreased embryo size

abnormal embryonic tissue morphology

abnormal embryonic neuroepithelium morphology

kinked neural tube

neural tube degeneration

notochord degeneration

abnormal somite development

abnormal somite size

delayed somite formation

pale yolk sac

abnormal vitelline vascular remodeling

Availability

Mouse Genotype

Notch1^sot/Notch1^sot

Notch1^tm1Con/Notch1^tm1Con

Notch1^tm1Grid/Notch1^tm1Grid

Notch1^tm1Pst/Notch1^tm1Pst

Notch1^tm1Rko/Notch1^tm1Rko

Notch1^tm2Pst/Notch1^tm2.1Pst

Notch1^tm1Agt/Notch1^tm1Agt
Tg(Tek-cre)1Ywa/0 (conditional)

Notch1^tm1Agt/Notch1^tm1Agt
Tg(Tek-cre)12Flv/0 (conditional)

Notch1^tm2Rko/Notch1^tm4(cre)Rko (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23