Nos2
Gene Detail

Symbol Name ID

Nos2 nitric oxide synthase 2, inducible MGI:97361

Synonyms

iNOS, Nos-2, Nos2a, NOS-II

Feature Type

protein coding gene

Genetic Map

Chromosome 11

46.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)

Sequence Map

Chr11:78920787-78960254 bp, + strand From VEGA annotation of GRCm38   39468 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Nos2 ± 2 cM)

Protein SuperFamily: nitric-oxide synthase, inducible
Gene Tree: Nos2

Human ortholog

NOS2 nitric oxide synthase 2, inducible NCBI Gene ID 4843
Human Synonyms: HEP-NOS, INOS, NOS, NOS2A
Human Chr17:26083792-26127555 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human NOS2 (2)

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Homozygous deletion of this gene alters susceptibility to infection, response to injury, sepsis and sensory stimuli, cardiac function, osteoclast, platelet and mammary gland physiology, tumor growth, testis and uterus morphology, diet-induced atherosclerosis, and blood, urine and glucose metabolism.

 
Human Diseases Modeled Using Mouse Nos2 (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (75 annotations)

Process	arginine catabolic process, blood vessel remodeling, ...
Component	cortical cytoskeleton, cytoplasm, ...
Function	arginine binding, calmodulin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (33 records)
Data Summary: Results (220)    Tissues (63)    Images (6)
Theiler Stages: 13, 15, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Western blot	6
RT-PCR	208
RNase protection	6

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(41) Genomic(3) cDNA(30) Primer pair(7) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000000146 (Evidence)
Ensembl Gene Model	ENSMUSG00000020826 (Evidence)
Entrez Gene	18126 (Evidence)
UniGene	2893
DFCI	TC1585345
DoTS	DT.527028
NIA Mouse Gene Index	U040163
EC	1.14.13.39
PDB	1DD7, 1DF1, 1DWV, 1DWW, 1DWX, 1JWJ, 1JWK, 1M8D, 1M8E, 1M8H, 1M8I, 1M9T, 1N2N, 1NOC, 1NOD, 1NOS, 1QOM, 1QW4, 1QW5, 1R35, 1VAF, 2BHJ, 2NOD, 2NOS, 2ORO, 2ORP, 2ORQ, 2ORR, 2ORS, 2ORT, 2Y37, 3DWJ, 3E65, 3E67, 3E68, 3E6L, 3E6N, 3E6O, 3E6T, 3E7I, 3E7M, 3E7T, 3EAI, 3EBD, 3EBF, 3GOF, 3NOD, 3NQS, 3NW2
Consensus CDS Project	CCDS25115.1
International Mouse Knockout Project Status	Nos2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000146	VEGA Gene Model | MGI Sequence Detail	39468	C57BL/6J
transcript	OTTMUST00000000466	VEGA | MGI Sequence Detail	4192	Not Applicable
polypeptide	OTTMUSP00000000202	VEGA | MGI Sequence Detail	1144	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(7) : SNPs(138 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003097	FAD-binding, type 1
InterPro	IPR017927	Ferredoxin reductase-type FAD-binding domain
InterPro	IPR001094	Flavodoxin
InterPro	IPR008254	Flavodoxin/nitric oxide synthase
InterPro	IPR001709	Flavoprotein pyridine nucleotide cytochrome reductase
InterPro	IPR023173	NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3
InterPro	IPR026009	Nitric-oxide synthase
InterPro	IPR012144	Nitric-oxide synthase, metazoa
InterPro	IPR004030	Nitric oxide synthase, oxygenase domain
InterPro	IPR001433	Oxidoreductase FAD/NAD(P)-binding
InterPro	IPR017938	Riboflavin synthase-like beta-barrel
Protein Ontology	PR:000001901	nitric oxide synthase, inducible

References

(Earliest) J:1868 Liew FY, et al., Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages. Eur J Immunol. 1991 Dec;21(12):3009-14
(Latest) J:193601 Winter SE, et al., Host-derived nitrate boosts growth of E. coli in the inflamed gut. Science. 2013 Feb 8;339(6120):708-11
All references(699)

Other accession IDs

MGD-MRK-12910, MGD-MRK-12913