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Nos2
Gene Detail
Symbol

Name
ID
Nos2
nitric oxide synthase 2, inducible
MGI:97361
Synonyms
iNOS, Nos-2, Nos2a, NOS-II
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(26)
Sequence Map
Chr11:78920787-78960254 bp, + strand
From VEGA annotation of GRCm38

  39468 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55473  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: NOS2
Protein SuperFamily: nitric-oxide synthase, inducible
Gene Tree: Nos2

Human
homologs
NOS2, nitric oxide synthase 2, inducible
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4843
neXtProt AC: NX_P35228

Human Synonyms: HEP-NOS, INOS, NOS, NOS2A

Human Chr (Location): 17q11.2; chr17:27756766-27804341 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human NOS2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(1) Targeted(7) Transgenic(3)
Genomic Mutations involving Nos2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous deletion of this gene alters susceptibility to infection, response to injury, sepsis and sensory stimuli, cardiac function, osteoclast, platelet and mammary gland physiology, tumor growth, testis and uterus morphology, diet-induced atherosclerosis, and blood, urine and glucose metabolism.
 
Human Diseases Modeled in Mice Using Nos2 (1)    Mutations Annotated to Human Diseases (4)    Phenotype Images(1)
Interactions
Nos2 interacts with 98 markers (Mir7b, Mir17, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (72 annotations)
Process arginine catabolic process, cellular response to drug, ...
Component cortical cytoskeleton, cytoplasm, ...
Function actin binding, arginine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (220)    Tissues (65)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 6
RT-PCR 208
RNase protection 6
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN nos2a, nos2b    NEW 
Molecular
reagents
All nucleic(41) Genomic(3) cDNA(30) Primer pair(7) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000000146 (Evidence)
Ensembl Gene Model ENSMUSG00000020826 (Evidence)
Entrez Gene 18126 (Evidence)
UniGene 2893
DFCI TC1585345
DoTS DT.527028
NIA Mouse Gene Index U040163
EC 1.14.13.39
PDB 1DWV, 1DWW, 1DWX, 1JWJ, 1JWK, 1M8D, 1M8E, 1M8H, 1M8I, 1M9T, 1N2N, 1NOC, 1NOD, 1NOS, 1QOM, 1VAF, 2BHJ, 2NOD, 2NOS, 2ORO, 2ORP, 2ORQ, 2ORR, 2ORS, 2ORT, 3DWJ, 3E6L, 3E6N, 3E6O, 3E6T, 3E7I, 3E7M, 3E7T, 3EAI, 3EBD, 3EBF, 3GOF, 3NOD, 3NQS, 1DD7, 1DF1, 1QW4, 1QW5, 1R35, 2Y37, 3E65, 3E67, 3E68, 3NW2, 4JS9, 4UX6
Consensus CDS Project CCDS25115.1
International Mouse Phenotyping Consortium Status Nos2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000146 VEGA Gene Model | MGI Sequence Detail 39468 C57BL/6J ±  kb
transcript OTTMUST00000000466 VEGA | MGI Sequence Detail 4192 Not Applicable 
polypeptide OTTMUSP00000000202 VEGA | MGI Sequence Detail 1144 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(7) : SNPs within 2kb(235 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003097 FAD-binding, type 1
InterPro IPR017927 Ferredoxin reductase-type FAD-binding domain
InterPro IPR001094 Flavodoxin
InterPro IPR008254 Flavodoxin/nitric oxide synthase
InterPro IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
InterPro IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3
InterPro IPR004030 Nitric oxide synthase, oxygenase domain
InterPro IPR001433 Oxidoreductase FAD/NAD(P)-binding
InterPro IPR017938 Riboflavin synthase-like beta-barrel
Protein Ontology PR:000001901 nitric oxide synthase, inducible
References
(Earliest) J:1868 Liew FY, et al., Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages. Eur J Immunol. 1991 Dec;21(12):3009-14
(Latest) J:221863 Lu G, et al., Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization. Nat Commun. 2015;6:6676
All references(735)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-12910, MGD-MRK-12913

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory