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Gene Detail

nitric oxide synthase 2, inducible
iNOS, Nos-2, Nos2a, NOS-II
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.74 cM
Detailed Genetic Map ± 1 cM

Mapping data(26)
Sequence Map
Chr11:78920787-78960254 bp, + strand
From VEGA annotation of GRCm38

  39468 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:55473  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: NOS2
Protein SuperFamily: nitric-oxide synthase, inducible
Gene Tree: Nos2

NOS2, nitric oxide synthase 2, inducible
Orthology source: HGNC, HomoloGene

NCBI Gene ID: 4843
neXtProt AC: NX_P35228

Human Synonyms: HEP-NOS, INOS, NOS, NOS2A

Human Chr (Location): 17q11.2; chr17:27756766-27804341 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human NOS2

alleles, and
All mutations/alleles(11) : Gene trapped(1) Targeted(7) Transgenic(3)
Genomic Mutations involving Nos2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Homozygous deletion of this gene alters susceptibility to infection, response to injury, sepsis and sensory stimuli, cardiac function, osteoclast, platelet and mammary gland physiology, tumor growth, testis and uterus morphology, diet-induced atherosclerosis, and blood, urine and glucose metabolism.
Human Diseases Modeled in Mice Using Nos2 (1)    Mutations Annotated to Human Diseases (4)    Phenotype Images(1)
Nos2 interacts with 98 markers (Mir7b, Mir17, Mir20a, ...)
Gene Ontology
All GO classifications: (72 annotations)
Process arginine catabolic process, cellular response to drug, ...
Component cortical cytoskeleton, cytoplasm, ...
Function actin binding, arginine binding, ...
External Resources: FuncBase
Literature Summary: (34 records)
Data Summary: Results (220)    Tissues (65)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 6
RT-PCR 208
RNase protection 6
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN nos2a, nos2b    NEW 
All nucleic(41) Genomic(3) cDNA(30) Primer pair(7) Other(1)
Microarray probesets(3)
Other database
VEGA Gene Model OTTMUSG00000000146 (Evidence)
Ensembl Gene Model ENSMUSG00000020826 (Evidence)
Entrez Gene 18126 (Evidence)
UniGene 2893
DFCI TC1585345
DoTS DT.527028
NIA Mouse Gene Index U040163
PDB 1DD7, 1DF1, 1DWV, 1DWW, 1DWX, 1JWJ, 1JWK, 1M8D, 1M8E, 1M8H, 1M8I, 1M9T, 1N2N, 1NOC, 1NOD, 1NOS, 1QOM, 1QW4, 1QW5, 1R35, 1VAF, 2BHJ, 2NOD, 2NOS, 2ORO, 2ORP, 2ORQ, 2ORR, 2ORS, 2ORT, 2Y37, 3DWJ, 3E65, 3E67, 3E68, 3E6L, 3E6N, 3E6O, 3E6T, 3E7I, 3E7M, 3E7T, 3EAI, 3EBD, 3EBF, 3GOF, 3NOD, 3NQS, 3NW2, 4JS9, 4UX6
Consensus CDS Project CCDS25115.1
International Mouse Phenotyping Consortium Status Nos2
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000146 VEGA Gene Model | MGI Sequence Detail 39468 C57BL/6J ±  kb
transcript OTTMUST00000000466 VEGA | MGI Sequence Detail 4192 Not Applicable 
polypeptide OTTMUSP00000000202 VEGA | MGI Sequence Detail 1144 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
RFLP(7) : SNPs within 2kb(235 from dbSNP Build 137)
InterPro IPR003097 FAD-binding, type 1
InterPro IPR017927 Ferredoxin reductase-type FAD-binding domain
InterPro IPR001094 Flavodoxin
InterPro IPR008254 Flavodoxin/nitric oxide synthase
InterPro IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
InterPro IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3
InterPro IPR004030 Nitric oxide synthase, oxygenase domain
InterPro IPR001433 Oxidoreductase FAD/NAD(P)-binding
InterPro IPR017938 Riboflavin synthase-like beta-barrel
Protein Ontology PR:000001901 nitric oxide synthase, inducible
(Earliest) J:1868 Liew FY, et al., Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages. Eur J Immunol. 1991 Dec;21(12):3009-14
(Latest) J:222122 Reho JJ, et al., Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis. Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1039-50
All references(736)
Disease annotation references (4)
accession IDs
MGD-MRK-12910, MGD-MRK-12913

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.0
The Jackson Laboratory