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Gene Detail
nitric oxide synthase 2, inducible
Synonyms iNOS, Nos-2, Nos2a, NOS-II
Feature Type protein coding gene
Genetic Map
Chromosome 11
46.74 cM
Detailed Genetic Map ± 1 cM

Mapping data(26)
Sequence Map
Chr11:78920787-78960254 bp, + strand
From VEGA annotation of GRCm38

  39468 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:55473  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: nitric-oxide synthase, inducible
Gene Tree: Nos2

Human Homolog NOS2, nitric oxide synthase 2, inducible
NCBI Gene ID 4843
neXtProt AC  NX_P35228
Human Synonyms  HEP-NOS, INOS, NOS, NOS2A
Human Chr (Location)  17q11.2; chr17:27756766-27800529 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human NOS2
alleles, and
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
Homozygous deletion of this gene alters susceptibility to infection, response to injury, sepsis and sensory stimuli, cardiac function, osteoclast, platelet and mammary gland physiology, tumor growth, testis and uterus morphology, diet-induced atherosclerosis, and blood, urine and glucose metabolism.
Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Nos2 interacts with 98 markers (Mir7b, Mir17, Mir20a, ...)
Gene Ontology
All GO classifications: (72 annotations)
Process arginine catabolic process, cellular response to interferon-gamma, ...
Component cortical cytoskeleton, cytoplasm, ...
Function actin binding, arginine binding, ...
External Resources: FuncBase
Literature Summary: (34 records)
Data Summary: Results (220)    Tissues (65)    Images (6)
Theiler Stages: 13, 15, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Western blot 6
RT-PCR 208
RNase protection 6
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(41) Genomic(3) cDNA(30) Primer pair(7) Other(1)
Microarray probesets(3)
Other database
VEGA Gene ModelOTTMUSG00000000146 (Evidence)
Ensembl Gene ModelENSMUSG00000020826 (Evidence)
Entrez Gene18126 (Evidence)
NIA Mouse Gene IndexU040163
PDB1DWV, 1DWW, 1DWX, 1JWJ, 1JWK, 1M8D, 1M8E, 1M8H, 1M8I, 1M9T, 1N2N, 1NOC, 1NOD, 1NOS, 1QOM, 1VAF, 2BHJ, 2NOD, 2NOS, 2ORO, 2ORP, 2ORQ, 2ORR, 2ORS, 2ORT, 3DWJ, 3E6L, 3E6N, 3E6O, 3E6T, 3E7I, 3E7M, 3E7T, 3EAI, 3EBD, 3EBF, 3GOF, 3NOD, 3NQS, 1DD7, 1DF1, 1QW4, 1QW5, 1R35, 2Y37, 3E65, 3E67, 3E68, 3NW2, 4JS9
Consensus CDS ProjectCCDS25115.1
International Mouse Knockout Project StatusNos2
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000146 VEGA Gene Model | MGI Sequence Detail 39468 C57BL/6J ±  kb
transcript OTTMUST00000000466 VEGA | MGI Sequence Detail 4192 Not Applicable 
polypeptide OTTMUSP00000000202 VEGA | MGI Sequence Detail 1144 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
Polymorphisms RFLP(7) : SNPs within 2kb(235 from dbSNP Build 137)
InterPro IPR003097 FAD-binding, type 1
InterPro IPR017927 Ferredoxin reductase-type FAD-binding domain
InterPro IPR001094 Flavodoxin
InterPro IPR008254 Flavodoxin/nitric oxide synthase
InterPro IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
InterPro IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain-3
InterPro IPR012144 Nitric-oxide synthase, metazoa
InterPro IPR004030 Nitric oxide synthase, oxygenase domain
InterPro IPR001433 Oxidoreductase FAD/NAD(P)-binding
InterPro IPR017938 Riboflavin synthase-like beta-barrel
Protein Ontology PR:000001901 nitric oxide synthase, inducible
References (Earliest) J:1868 Liew FY, et al., Resistance to Leishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages. Eur J Immunol. 1991 Dec;21(12):3009-14
(Latest) J:209894 Everts B, et al., TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKvarepsilon supports the anabolic demands of dendritic cell activation. Nat Immunol. 2014 Apr;15(4):323-32
All references(728)
accession IDs
MGD-MRK-12910, MGD-MRK-12913

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory