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Nos2 Gene Detail
Summary
  • Symbol
    Nos2
  • Name
    nitric oxide synthase 2, inducible
  • Synonyms
    iNOS, Nos-2, Nos2a, NOS-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:97361
    NCBI Gene: 18126
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78920787-78960232 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    235 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97361
protein coding gene Chr11:78920787-78960254 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018791
protein coding gene Chr11:79978936-80021467 (+)
A/J MGP_AJ_G0018758
protein coding gene Chr11:76908010-76947472 (+)
AKR/J MGP_AKRJ_G0018728
protein coding gene Chr11:79215772-79255173 (+)
BALB/cJ MGP_BALBcJ_G0018731
protein coding gene Chr11:77320065-77359027 (+)
C3H/HeJ MGP_C3HHeJ_G0018545
protein coding gene Chr11:79263220-79303324 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019183
protein coding gene Chr11:82443125-82484262 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016818
protein coding gene Chr11:73866986-73905083 (+)
CAST/EiJ MGP_CASTEiJ_G0018100
protein coding gene Chr11:79729557-79770158 (+)
CBA/J MGP_CBAJ_G0018516
protein coding gene Chr11:86032831-86072186 (+)
DBA/2J MGP_DBA2J_G0018624
protein coding gene Chr11:76473641-76513849 (+)
FVB/NJ MGP_FVBNJ_G0018613
protein coding gene Chr11:76067304-76107805 (+)
LP/J MGP_LPJ_G0018694
protein coding gene Chr11:80497263-80537541 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018640
protein coding gene Chr11:86416139-86460683 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019223
protein coding gene Chr11:79472471-79514711 (+)
PWK/PhJ MGP_PWKPhJ_G0017870
protein coding gene Chr11:77277909-77318456 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017661
protein coding gene Chr11:79087804-79129974 (+)
WSB/EiJ MGP_WSBEiJ_G0018152
protein coding gene Chr11:79298802-79339346 (+)



Homology
more
  • Human Ortholog
    NOS2, nitric oxide synthase 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    NOS2, nitric oxide synthase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEP-NOS, INOS, NOS, NOS2A
  • Links
    NCBI Gene ID: 4843
    neXtProt AC: NX_P35228
    UniProt: P35228

  • Chr Location
    17q11.2; chr17:27756766-27804339 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Nos2 mouse models; 2 with human NOS2 associations

Human Disease Mouse Models
      
IDs
View 5 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    159 phenotypes from 7 alleles in 17 genetic backgrounds
    123 phenotypes from multigenic genotypes
    1 images
    602 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous deletion of this gene alters susceptibility to infection, response to injury, sepsis and sensory stimuli, cardiac function, osteoclast, platelet and mammary gland physiology, tumor growth, testis and uterus morphology, diet-induced atherosclerosis, and blood, urine and glucose metabolism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18126 NCBI Gene Model | MGI Sequence Detail 39446 C57BL/6J ±  kb
    transcript NM_010927 RefSeq | MGI Sequence Detail 4164 Not Specified  
    polypeptide P29477 UniProt | EBI | MGI Sequence Detail 1144 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 3
      cDNA 32
      Primer pair 7
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12910, MGD-MRK-12913
    References
    more
    • Summaries
      All 899
      Developmental Gene Expression 40
      Diseases 7
      Gene Ontology 25
      Phenotypes 602
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:276897 Lacey CA, et al., IFN-gamma-dependent nitric oxide suppresses Brucella-induced arthritis by inhibition of inflammasome activation. J Leukoc Biol. 2019 Jul;106(1):27-34

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory