Sequence Detail

ID/Version

P29477 Q6P6A0 O70515 Q5SXT3 O70516 Q8R410 (UniProt | EBI)

Last sequence update: 1993-04-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Nitric oxide synthase, inducible; EC=1.14.13.39 {ECO:0000250|UniProtKB:P35228};AltName: Full=Inducible NO synthase; Short=Inducible NOS; Short=iNOS;AltName: Full=Macrophage NOS; Short=MAC-NOS;AltName: Full=NOS

Provider

SWISS-PROT

Sequence

Polypeptide 1144 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nos2	nitric oxide synthase 2, inducible	100	113	4	18

Sequence references in MGI

J:528 Xie QW, et al., Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science. 1992 Apr 10;256(5054):225-8
J:1709 Lowenstein CJ, et al., Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6711-5
J:2324 Lyons CR, et al., Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem. 1992 Mar 25;267(9):6370-4
J:39499 Kone BC, et al., Role of NF-kappa B in the regulation of inducible nitric oxide synthase in an MTAL cell line. Am J Physiol. 1995 Nov;269(5 Pt 2):F718-29
J:56752 Teuscher C, et al., Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis. J Immunol. 1999 Aug 15;163(4):2262-6
J:58509 Ghosh DK, et al., Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction. EMBO J. 1999 Nov 15;18(22):6260-70
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:162874 Kuang Z, et al., The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation. J Cell Biol. 2010 Jul 12;190(1):129-41
J:168203 Kim SF, et al., Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science. 2005 Dec 23;310(5756):1966-70
J:180208 Erez A, et al., Requirement of argininosuccinate lyase for systemic nitric oxide production. Nat Med. 2011 Dec;17(12):1619-26
J:180997 Niu S, et al., The circadian deadenylase Nocturnin is necessary for stabilization of the iNOS mRNA in mice. PLoS One. 2011;6(11):e26954
J:343111 Ranjan R, et al., The transcription factor nuclear factor of activated T cells c3 modulates the function of macrophages in sepsis. J Innate Immun. 2014;6(6):754-64