About   Help   FAQ
Mapt
Gene Detail
Symbol

Name
ID
Mapt
microtubule-associated protein tau
MGI:97180
Synonyms
Mtapt, Tau
Feature Type
protein coding gene
Genetic Map
Chromosome 11
67.79 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:104231390-104332090 bp, + strand
From VEGA annotation of GRCm38

  100701 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74962  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: MAPT
Gene Tree: Mapt

Human
homologs
MAPT, microtubule-associated protein tau
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4137
neXtProt AC: NX_P10636

Human Synonyms: DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU

Human Chr (Location): 17q21.1; chr17:45894382-46028334 (+)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human MAPT

Mutations,
alleles, and
phenotypes
All mutations/alleles(461) : Gene trapped(407) Targeted(25) Transgenic(29)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit altered performance in behavioral tests and show mircotubule changes in small-calibre axons. Embryonic hippocampal cultures from mutants exhibit delayed axonal and neuritic maturation.
 
Mutations Annotated to Human Diseases (25)   
Interactions
Mapt interacts with 320 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process adult walking behavior, apoptotic process, ...
Component axon, axonal growth cone, ...
Function apolipoprotein binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (45 records)
Data Summary: Results (392)    Tissues (91)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 342
Western blot 39
RT-PCR 8
cDNA source data(26)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase mapt ; ZFIN mapta, maptb    NEW 
Molecular
reagents
All nucleic(32) Genomic(3) cDNA(26) Primer pair(3)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000003153 (Evidence)
Ensembl Gene Model ENSMUSG00000018411 (Evidence)
Entrez Gene 17762 (Evidence)
DFCI TC1577412, TC1582042, TC1591009, TC1595991, TC1619579, TC1621917, TC1665909
DoTS DT.101204582, DT.101383559, DT.101383564, DT.101714060, DT.528743, DT.91341342, DT.97351013
NIA Mouse Gene Index U013429
Consensus CDS Project CCDS25527.1, CCDS25528.1
International Mouse Phenotyping Consortium Status Mapt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003153 VEGA Gene Model | MGI Sequence Detail 100701 C57BL/6J ±  kb
transcript OTTMUST00000006512 VEGA | MGI Sequence Detail 2250 Not Applicable 
polypeptide OTTMUSP00000003080 VEGA | MGI Sequence Detail 749 Not Applicable 

For the selected sequences
All sequences(138) RefSeq(42) UniProt(10)
Polymorphisms
SNPs within 2kb(548 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027324 Microtubule associated protein MAP2/MAP4/Tau
InterPro IPR001084 Tau and MAP proteins tubulin-binding repeat
InterPro IPR002955 Tau protein
Protein Ontology PR:000010173 microtubule-associated protein tau
References
(Earliest) J:17288 Drubin DG, et al., Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes. J Cell Biol. 1984 Mar;98(3):1090-7
(Latest) J:221676 Miller N, et al., Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy. J Neurosci. 2015 Apr 15;35(15):6038-50
All references(278)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-12590, MGD-MRK-14720, MGI:2144146, MGI:2144478

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory