Mapt
Gene Detail

Symbol Name ID

Mapt microtubule-associated protein tau MGI:97180

Synonyms

Mtapt, Tau

Feature Type

protein coding gene

Genetic Map

Chromosome 11

67.79 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr11:104231390-104332090 bp, + strand From VEGA annotation of GRCm38   100701 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74962  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mapt

Human homologs

Human Homolog		MAPT, microtubule-associated protein tau
NCBI Gene ID		4137
neXtProt AC		NX_P10636
Human Synonyms		DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU
Human Chr (Location)		17q21.1; chr17:43971748-44105700 (+)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human MAPT

Alleles and phenotypes

All alleles(429) : Targeted(22) Gene trapped(407)
 

Homozygous mutants exhibit altered performance in behavioral tests and show mircotubule changes in small-calibre axons. Embryonic hippocampal cultures from mutants exhibit delayed axonal and neuritic maturation.

 
Human Diseases Modeled Using Mouse Mapt (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (49 annotations)

Process	adult walking behavior, apoptotic process, ...
Component	axon, axonal growth cone, ...
Function	apolipoprotein binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (38 records)
Data Summary: Results (347)    Tissues (45)    Images (46)
Theiler Stages: 17, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	300
Western blot	39
RT-PCR	8

cDNA source data(23)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(3) cDNA(23) Primer pair(3)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000003153 (Evidence)
Ensembl Gene Model	ENSMUSG00000018411 (Evidence)
Entrez Gene	17762 (Evidence)
DFCI	TC1577412, TC1582042, TC1591009, TC1595991, TC1619579, TC1621917, TC1665909
DoTS	DT.101204582, DT.101383559, DT.101383564, DT.101714060, DT.528743, DT.91341342, DT.97351013
NIA Mouse Gene Index	U013429
Consensus CDS Project	CCDS25527.1, CCDS25528.1
International Mouse Knockout Project Status	Mapt

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003153	VEGA Gene Model | MGI Sequence Detail	100701	C57BL/6J
transcript	OTTMUST00000006512	VEGA | MGI Sequence Detail	2250	Not Applicable
polypeptide	OTTMUSP00000003080	VEGA | MGI Sequence Detail	749	Not Applicable

All sequences(95) RefSeq(4) UniProt(9)

Polymorphisms

SNPs(427 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR027324	Microtubule associated protein MAP2/MAP4/Tau
InterPro	IPR001084	Tau and MAP proteins tubulin-binding repeat
InterPro	IPR002955	Tau protein
Protein Ontology	PR:000010173	microtubule-associated protein tau

References

(Earliest) J:17288 Drubin DG, et al., Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes. J Cell Biol. 1984 Mar;98(3):1090-7
(Latest) J:194513 Xiong Y, et al., Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging. 2013 Mar;34(3):745-56
All references(222)

Other accession IDs

MGD-MRK-12590, MGD-MRK-14720, MGI:2144146, MGI:2144478