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Mapt
Gene Detail
 Symbol
Name
ID
Mapt
microtubule-associated protein tau
MGI:97180
Synonyms Mtapt, Tau
Feature Type protein coding gene
Genetic Map
Chromosome 11
67.79 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:104231390-104332090 bp, + strand
From VEGA annotation of GRCm38

  100701 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74962  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Mapt

Human
homologs
Human Homolog MAPT, microtubule-associated protein tau
NCBI Gene ID 4137
neXtProt AC  NX_P10636
Human Synonyms  DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU
Human Chr (Location)  17q21.1; chr17:45894336-46028334 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human MAPT
Mutations,
alleles, and
phenotypes
All mutations/alleles(430) : Gene trapped(407) Targeted(23)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants exhibit altered performance in behavioral tests and show mircotubule changes in small-calibre axons. Embryonic hippocampal cultures from mutants exhibit delayed axonal and neuritic maturation.
 
Human Diseases Modeled Using Mouse Mapt (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Mapt interacts with 321 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process adult walking behavior, apoptotic process, ...
Component axon, axonal growth cone, ...
Function apolipoprotein binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (393)    Tissues (92)    Images (58)
Theiler Stages: 16, 17, 21, 22, 23, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 343
Western blot 39
RT-PCR 8
cDNA source data(26)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(3) cDNA(26) Primer pair(3)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000003153 (Evidence)
Ensembl Gene ModelENSMUSG00000018411 (Evidence)
Entrez Gene17762 (Evidence)
DFCITC1577412, TC1582042, TC1591009, TC1595991, TC1619579, TC1621917, TC1665909
DoTSDT.101204582, DT.101383559, DT.101383564, DT.101714060, DT.528743, DT.91341342, DT.97351013
NIA Mouse Gene IndexU013429
Consensus CDS ProjectCCDS25527.1, CCDS25528.1
International Mouse Knockout Project StatusMapt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003153 VEGA Gene Model | MGI Sequence Detail 100701 C57BL/6J ±  kb
transcript OTTMUST00000006512 VEGA | MGI Sequence Detail 2250 Not Applicable 
polypeptide OTTMUSP00000003080 VEGA | MGI Sequence Detail 749 Not Applicable 

For the selected sequences
All sequences(123) RefSeq(28) UniProt(9)
Polymorphisms SNPs within 2kb(548 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027324 Microtubule associated protein MAP2/MAP4/Tau
InterPro IPR001084 Tau and MAP proteins tubulin-binding repeat
InterPro IPR002955 Tau protein
Protein Ontology PR:000010173 microtubule-associated protein tau
References (Earliest) J:17288 Drubin DG, et al., Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes. J Cell Biol. 1984 Mar;98(3):1090-7
(Latest) J:211349 Ma QL, et al., Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. J Neurosci. 2014 May 21;34(21):7124-36
All references(256)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-12590, MGD-MRK-14720, MGI:2144146, MGI:2144478

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory