About   Help   FAQ
Mapt
Gene Detail
 Symbol
Name
ID
Mapt
microtubule-associated protein tau
MGI:97180
Synonyms Mtapt, Tau
Feature Type protein coding gene
Genetic Map
Chromosome 11
67.79 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:104231390-104332090 bp, + strand
From VEGA annotation of GRCm38

  100701 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74962  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mapt

Human
homologs
Human Homolog MAPT, microtubule-associated protein tau
NCBI Gene ID 4137
neXtProt AC  NX_P10636
Human Synonyms  DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU
Human Chr (Location)  17q21.1; chr17:45894336-46028334 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human MAPT
Alleles
and
phenotypes
All alleles(430) : Targeted(23) Gene trapped(407)
 
Homozygous mutants exhibit altered performance in behavioral tests and show mircotubule changes in small-calibre axons. Embryonic hippocampal cultures from mutants exhibit delayed axonal and neuritic maturation.
 
Human Diseases Modeled Using Mouse Mapt (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process adult walking behavior, apoptotic process, ...
Component axon, axonal growth cone, ...
Function apolipoprotein binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (40 records)
Data Summary: Results (393)    Tissues (91)    Images (58)
Theiler Stages: 16, 17, 21, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 343
Western blot 39
RT-PCR 8
cDNA source data(26)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(32) Genomic(3) cDNA(26) Primer pair(3)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000003153 (Evidence)
Ensembl Gene ModelENSMUSG00000018411 (Evidence)
Entrez Gene17762 (Evidence)
DFCITC1577412, TC1582042, TC1591009, TC1595991, TC1619579, TC1621917, TC1665909
DoTSDT.101204582, DT.101383559, DT.101383564, DT.101714060, DT.528743, DT.91341342, DT.97351013
NIA Mouse Gene IndexU013429
Consensus CDS ProjectCCDS25527.1, CCDS25528.1
International Mouse Knockout Project StatusMapt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003153 VEGA Gene Model | MGI Sequence Detail 100701 C57BL/6J ±  kb
transcript OTTMUST00000006512 VEGA | MGI Sequence Detail 2250 Not Applicable 
polypeptide OTTMUSP00000003080 VEGA | MGI Sequence Detail 749 Not Applicable 

For the selected sequences
All sequences(123) RefSeq(28) UniProt(9)
Polymorphisms SNPs within 2kb(548 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027324 Microtubule associated protein MAP2/MAP4/Tau
InterPro IPR001084 Tau and MAP proteins tubulin-binding repeat
InterPro IPR002955 Tau protein
Protein Ontology PR:000010173 microtubule-associated protein tau
References (Earliest) J:17288 Drubin DG, et al., Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes. J Cell Biol. 1984 Mar;98(3):1090-7
(Latest) J:205554 Pivetta C, et al., Motor-circuit communication matrix from spinal cord to brainstem neurons revealed by developmental origin. Cell. 2014 Jan 30;156(3):537-48
All references(243)
Other
accession IDs
MGD-MRK-12590, MGD-MRK-14720, MGI:2144146, MGI:2144478

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory