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Symbol
Name
ID
Mapt
microtubule-associated protein tau
MGI:97180
Phenotype annotations related to behavior/neurological
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Photophobia
Depression
Emotional lability
Low frustration tolerance
Diminished motivation
Apathy
Abnormal sexual behavior
Inappropriate laughter
Reduced social reciprocity
Personality changes
Polyphagia
Disinhibition
Impulsivity
Agitation
Restless legs
Abnormal repetitive mannerisms
Hyperorality
Weak voice
Disease(s) Associated with MAPT
frontotemporal dementia
late onset Parkinson's disease
Parkinson's disease
Pick's disease
progressive supranuclear palsy

Mouse Phenotypes
behavior/neurological phenotype
decreased susceptibility to pharmacologically induced seizures
impaired contextual conditioning behavior
impaired cued conditioning behavior
abnormal motor learning
decreased exploration in new environment
enhanced spatial learning
increased fluid intake
decreased grip strength
Availability Mouse Genotype
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt *
Mapttm1(Setdb1)Akba/Mapttm1(Setdb1)Akba *
Mapttm1.1Cole/Mapttm1.1Cole *
Mapttm1b(EUCOMM)Hmgu/Mapttm1b(EUCOMM)Hmgu
Mapttm1Hnd/Mapttm1Hnd
Mapttm1Hnd/Mapt+
Chattm2(cre)Lowl/Chat+
Mapttm3(Sema3e)Arbr/Mapttm3(Sema3e)Arbr  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory