Symbol Name ID |
Mapt
microtubule-associated protein tau MGI:97180 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Photophobia |
Depression |
Emotional lability |
Low frustration tolerance |
Diminished motivation |
Apathy |
Abnormal sexual behavior |
Inappropriate laughter |
Reduced social reciprocity |
Personality changes |
Polyphagia |
Disinhibition |
Impulsivity |
Agitation |
Restless legs |
Abnormal repetitive mannerisms |
Hyperorality |
Weak voice |
Disease(s) Associated with MAPT | ||||||||||||||||||
frontotemporal dementia | ||||||||||||||||||
late onset Parkinson's disease | ||||||||||||||||||
Parkinson's disease | ||||||||||||||||||
Pick's disease | ||||||||||||||||||
progressive supranuclear palsy |
Mouse Phenotypes | behavior/neurological phenotype |
decreased susceptibility to pharmacologically induced seizures |
impaired contextual conditioning behavior |
impaired cued conditioning behavior |
abnormal motor learning |
decreased exploration in new environment |
enhanced spatial learning |
increased fluid intake |
decreased grip strength |
|
Availability | Mouse Genotype | |||||||||
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt | * | |||||||||
Mapttm1(Setdb1)Akba/Mapttm1(Setdb1)Akba | * | |||||||||
Mapttm1.1Cole/Mapttm1.1Cole | * | |||||||||
Mapttm1b(EUCOMM)Hmgu/Mapttm1b(EUCOMM)Hmgu | ||||||||||
Mapttm1Hnd/Mapttm1Hnd | ||||||||||
Mapttm1Hnd/Mapt+ | ||||||||||
Chattm2(cre)Lowl/Chat+ Mapttm3(Sema3e)Arbr/Mapttm3(Sema3e)Arbr (conditional) |
* |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/19/2024 MGI 6.23 |
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