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Mafg Gene Detail
Summary
  • Symbol
    Mafg
  • Name
    v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
  • Synonyms
    C630022N07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:96911
    NCBI Gene: 17134
  • Gene Overview
    MyGene.info: MAFG
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:120625117-120633600 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      8484 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 84.35 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MAFG, MAF bZIP transcription factor G
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MAFG, MAF bZIP transcription factor G
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hMAF
  • Links
    NCBI Gene ID: 4097
    neXtProt AC: NX_O15525
    UniProt: O15525

  • Chr Location
    17q25.3; chr17:81918269-81927711 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit a background sensitive increase in perinatal lethality, hemopoietic abnormalities, and locomotor difficulties.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    19
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    384
  • Tissues
    237
  • cDNA Data
    10
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000004094 VEGA Gene Model | MGI Sequence Detail 8484 C57BL/6J ±  kb
    transcript OTTMUST00000009213 VEGA | MGI Sequence Detail 1104 Not Applicable  
    polypeptide OTTMUSP00000004493 VEGA | MGI Sequence Detail 162 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      18 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 10
      Primer pair 4

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-12103, MGI:2144026, MGI:2441918
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 11
      Gene Ontology 10
      Phenotypes 19
    • Earliest
      J:16848 Igarashi K, et al., Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins [see comments]. Nature. 1994 Feb 10;367(6463):568-72
    • Latest
      J:219776 de Aguiar Vallim TQ, et al., MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell Metab. 2015 Feb 3;21(2):298-310
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory