Mafg MGI Mouse Gene Detail - MGI:96911 - v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)

Mafg Gene Detail

Symbol

Mafg
Name

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
Synonyms

C630022N07Rik

Feature Type

protein coding gene
IDs

MGI:96911
NCBI Gene: 17134
Gene Overview

MyGene.info: MAFG

Sequence Map

Chr11:120625117-120633600 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

8484 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 84.35 cM
Mapping Data

3 experiments

Human Ortholog

MAFG, MAF bZIP transcription factor G

Vertebrate Orthologs

11

Human Ortholog

MAFG, MAF bZIP transcription factor G
Orthology source: HomoloGene, HGNC
Synonyms

hMAF
Links

HGNC:6781

NCBI Gene ID: 4097

neXtProt AC: NX_O15525

UniProt: O15525
Chr Location

17q25.3; chr17:81918269-81927711 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 81816
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: MAFG
Protein SuperFamily

transcription factor MafK
Gene Tree

Mafg

less

Phenotype Summary

6 phenotypes from 1 allele in 2 genetic backgrounds
16 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

59
Gene trapped

56
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

Mice homozygous for disruptions in this gene exhibit a background sensitive increase in perinatal lethality, hemopoietic abnormalities, and locomotor difficulties.

less

All GO Annotations

18
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

384
Tissues

237
cDNA Data

10
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MAFG

ZFIN mafga, mafgb

less

Mafg interacts with 408 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

less

All Sequences

55
RefSeq

12
UniProt

2
CCDS

CCDS25748.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000004094	VEGA Gene Model \| MGI Sequence Detail	8484	C57BL/6J	± kb
transcript	OTTMUST00000009213	VEGA \| MGI Sequence Detail	1104	Not Applicable
polypeptide	OTTMUSP00000004493	VEGA \| MGI Sequence Detail	162	Not Applicable

less

SNPs within 2kb

18 from dbSNP Build 142

RFLP

1

less

UniProt

2 Sequences
Protein Ontology

PR:000010050 transcription factor MafG

(term hierarchy)
PDB

1K1V, 3A5T
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR004826 Basic leucine zipper domain, Maf-type

IPR024874 Transcription factor Maf family

IPR028551 Transcription factor MafG

IPR008917 Transcription factor, Skn-1-like, DNA-binding domain

less

All nucleic 15

Genomic 1

cDNA 10

Primer pair 4

Microarray probesets 8

less

MGD-MRK-12103, MGI:2144026, MGI:2441918

Summaries

All 56

Developmental Gene Expression 11

Gene Ontology 9

Phenotypes 19
Earliest

J:16848 Igarashi K, et al., Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins [see comments]. Nature. 1994 Feb 10;367(6463):568-72
Latest

J:219776 de Aguiar Vallim TQ, et al., MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell Metab. 2015 Feb 3;21(2):298-310

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/12/2017 MGI 6.10