Mafg
Gene Detail

Symbol

Name
ID

Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
MGI:96911

Synonyms

C630022N07Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11
84.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:120625117-120633600 bp, - strand From VEGA annotation of GRCm38   8484 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:81816  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: transcription factor MafK
Gene Tree: Mafg

Human
homologs

Human Homolog		MAFG, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
NCBI Gene ID		4097
neXtProt AC		NX_O15525
Human Synonyms		hMAF
Human Chr (Location)		17q25.3; chr17:81918269-81927711 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(59) : Gene trapped(56) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruptions in this gene exhibit a background sensitive increase in perinatal lethality, hemopoietic abnormalities, and locomotor difficulties.

 

Interactions

Mafg interacts with 409 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (16 annotations)

Process	adult behavior, in utero embryonic development, ...
Component	cell, nucleus
Function	DNA binding, protein heterodimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)

Data Summary: Results (350)    Tissues (214)    Images (54)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	307
In situ reporter (knock in)	11
RT-PCR	32

cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(15) Genomic(1) cDNA(10) Primer pair(4)
Microarray probesets(8)

Other database
links

VEGA Gene Model	OTTMUSG00000004094 (Evidence)
Ensembl Gene Model	ENSMUSG00000051510 (Evidence)
Entrez Gene	17134 (Evidence)
DFCI	TC1578289, TC1597855, TC1670250
DoTS	DT.101378191, DT.110514228, DT.530231
PDB	1K1V, 3A5T
Consensus CDS Project	CCDS25748.1
International Mouse Knockout Project Status	Mafg

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004094	VEGA Gene Model | MGI Sequence Detail	8484	C57BL/6J
transcript	OTTMUST00000009210	VEGA | MGI Sequence Detail	4923	Not Applicable
polypeptide	OTTMUSP00000004490	VEGA | MGI Sequence Detail	162	Not Applicable

All sequences(53) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(1) : SNPs within 2kb(18 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR004826	Basic leucine zipper domain, Maf-type
InterPro	IPR008917	Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro	IPR024874	Transcription factor Maf
Protein Ontology	PR:000010050	transcription factor MafG

References

(Earliest) J:16848 Igarashi K, et al., Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins [see comments]. Nature. 1994 Feb 10;367(6463):568-72
(Latest) J:214095 Osipovich AB, et al., Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development. 2014 Aug;141(15):2939-49
All references(56)

Other
accession IDs

MGD-MRK-12103, MGI:2144026, MGI:2441918