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Mafg
Gene Detail
Symbol

Name
ID
Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
MGI:96911
Synonyms
C630022N07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
84.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:120625117-120633600 bp, - strand
From VEGA annotation of GRCm38

  8484 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81816  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: MAFG
Protein SuperFamily: transcription factor MafK
Gene Tree: Mafg

Human
homologs
MAFG, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4097
neXtProt AC: NX_O15525

Human Synonyms: hMAF

Human Chr (Location): 17q25.3; chr17:81918269-81931560 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(59) : Gene trapped(56) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene exhibit a background sensitive increase in perinatal lethality, hemopoietic abnormalities, and locomotor difficulties.
 
Interactions
Mafg interacts with 408 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process adult behavior, in utero embryonic development, ...
Component cell, nucleus
Function DNA binding, protein heterodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (350)    Tissues (214)    Images (54)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 307
In situ reporter (knock in) 11
RT-PCR 32
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA MAFG ; Xenbase mafg ; ZFIN mafga, mafgb    NEW 
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(10) Primer pair(4)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000004094 (Evidence)
Ensembl Gene Model ENSMUSG00000051510 (Evidence)
Entrez Gene 17134 (Evidence)
DFCI TC1578289, TC1597855, TC1670250
DoTS DT.101378191, DT.110514228, DT.530231
PDB 1K1V, 3A5T
Consensus CDS Project CCDS25748.1
International Mouse Phenotyping Consortium Status Mafg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004094 VEGA Gene Model | MGI Sequence Detail 8484 C57BL/6J ±  kb
transcript OTTMUST00000009210 VEGA | MGI Sequence Detail 4923 Not Applicable 
polypeptide OTTMUSP00000004490 VEGA | MGI Sequence Detail 162 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro IPR024874 Transcription factor Maf
Protein Ontology PR:000010050 transcription factor MafG
References
(Earliest) J:16848 Igarashi K, et al., Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins [see comments]. Nature. 1994 Feb 10;367(6463):568-72
(Latest) J:219776 de Aguiar Vallim TQ, et al., MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell Metab. 2015 Feb 3;21(2):298-310
All references(58)
Other
accession IDs
MGD-MRK-12103, MGI:2144026, MGI:2441918

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory