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Lyn Gene Detail
Summary
  • Symbol
    Lyn
  • Name
    LYN proto-oncogene, Src family tyrosine kinase
  • Synonyms
    Hck-2, Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
  • Feature Type
    protein coding gene
  • IDs
    MGI:96892
    NCBI Gene: 17096
  • Gene Overview
    MyGene.info: LYN
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:3678121-3791612 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 2.05 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    742 from dbSNP Build 142
  • Strain Annotations
    16
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96892
protein coding gene Chr4:3678115-3813122 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028023
protein coding gene Chr4:149294-267788 (+)
A/J MGP_AJ_G0027981
protein coding gene Chr4:171529-315648 (+)
AKR/J MGP_AKRJ_G0027947
protein coding gene Chr4:148515-267395 (+)
BALB/cJ MGP_BALBcJ_G0027993
protein coding gene Chr4:141560-304016 (+)
C3H/HeJ MGP_C3HHeJ_G0027723
protein coding gene Chr4:319055-445824 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028436
protein coding gene Chr4:253641-412833 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0027176
protein coding gene Chr4:155866-322651 (+)
CBA/J MGP_CBAJ_G0027698
protein coding gene Chr4:206518-287022 (+)
DBA/2J MGP_DBA2J_G0027838
protein coding gene Chr4:155008-315370 (+)
FVB/NJ MGP_FVBNJ_G0027805
protein coding gene Chr4:128443-244052 (+)
LP/J MGP_LPJ_G0027949
protein coding gene Chr4:194026-317570 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027838
protein coding gene Chr4:309493-472321 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028495
protein coding gene Chr4:157234-285054 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0026728
protein coding gene Chr4:144212-297072 (+)
WSB/EiJ MGP_WSBEiJ_G0027256
protein coding gene Chr4:251684-406315 (+)



Homology
more
  • Human Ortholog
    LYN, LYN proto-oncogene, Src family tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LYN, LYN proto-oncogene, Src family tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JTK8, p53Lyn, p56Lyn
  • Links
    NCBI Gene ID: 4067
    neXtProt AC: NX_P07948
    UniProt: P07948

  • Chr Location
    8q12.1; chr8:55877305-56012447 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Lyn mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    99 phenotypes from 14 alleles in 18 genetic backgrounds
    63 phenotypes from multigenic genotypes
    3 images
    201 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit splenomegaly, reduced numbers of peripheral B cells, impaired immune responses, IgM hyperglobulinemia, autoimmunity with glomerulonephritis, and monocyte/macrophage tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17096 NCBI Gene Model | MGI Sequence Detail 113492 C57BL/6J ±  kb
    transcript NM_001111096 RefSeq | MGI Sequence Detail 3456 C57BL/6  
    polypeptide P25911 UniProt | EBI | MGI Sequence Detail 512 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 12
      cDNA 96
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10668, MGD-MRK-12071, MGI:2140121
    References
    more
    • Summaries
      All 313
      Developmental Gene Expression 11
      Diseases 2
      Gene Ontology 37
      Phenotypes 201
    • Earliest
      J:8639 Yamanashi Y, et al., The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol. 1987 Jan;7(1):237-43
    • Latest
      J:264511 Pore D, et al., Cutting Edge: Deletion of Ezrin in B Cells of Lyn-Deficient Mice Downregulates Lupus Pathology. J Immunol. 2018 Sep 1;201(5):1353-1358

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory