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Lyn
Gene Detail
 Symbol
Name
ID
Lyn
Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
MGI:96892
Synonyms Hck-2
Feature Type protein coding gene
Genetic Map
Chromosome 4
2.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr4:3678115-3813122 bp, + strand
From VEGA annotation of GRCm38

  135008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55649  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Lyn

Human
homologs
Human Homolog LYN, LYN proto-oncogene, Src family tyrosine kinase
NCBI Gene ID 4067
neXtProt AC  NX_P07948
Human Synonyms  JTK8, p53Lyn, p56Lyn
Human Chr (Location)  8q13; chr8:55879827-56012447 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(3) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit splenomegaly, reduced numbers of peripheral B cells, impaired immune responses, IgM hyperglobulinemia, autoimmunity with glomerulonephritis, and monocyte/macrophage tumors.
 
Human Diseases Modeled Using Mouse Lyn (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Lyn interacts with 225 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (123 annotations)
Process B cell homeostasis, B cell receptor signaling pathway, ...
Component cell, cell-cell adherens junction, ...
Function ATP binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 46
cDNA source data(92)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(108) Genomic(12) cDNA(94) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000004398 (Evidence)
Ensembl Gene ModelENSMUSG00000042228 (Evidence)
Entrez Gene17096 (Evidence)
UniGene317331
DFCITC1576685, TC1583714, TC1633161
DoTSDT.101311785, DT.101400667, DT.91597006, DT.99859329
NIA Mouse Gene IndexU041317
EC2.7.10.2
PDB2ZVA, 2ZV7, 2ZV8, 2ZV9
Consensus CDS ProjectCCDS17939.1, CCDS51109.1
International Mouse Knockout Project StatusLyn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004398 VEGA Gene Model | MGI Sequence Detail 135008 C57BL/6J ±  kb
transcript OTTMUST00000009967 VEGA | MGI Sequence Detail 3463 Not Applicable 
polypeptide OTTMUSP00000004774 VEGA | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(5)
Polymorphisms RFLP(3) : SNPs within 2kb(1227 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1901)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000010002 tyrosine-protein kinase Lyn
References (Earliest) J:8639 Yamanashi Y, et al., The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol. 1987 Jan;7(1):237-43
(Latest) J:210183 Lovewell RR, et al., Pseudomonas aeruginosa flagellar motility activates the phagocyte PI3K/Akt pathway to induce phagocytic engulfment. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1;306(7):L698-707
All references(257)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10668, MGD-MRK-12071, MGI:2140121

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory