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Lyn
Gene Detail
Symbol

Name
ID
Lyn
Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
MGI:96892
Synonyms
Hck-2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
2.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr4:3678115-3813122 bp, + strand
From VEGA annotation of GRCm38

  135008 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55649  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LYN
Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Lyn

Human
homologs
LYN, LYN proto-oncogene, Src family tyrosine kinase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4067
neXtProt AC: NX_P07948

Human Synonyms: JTK8, p53Lyn, p56Lyn

Human Chr (Location): 8q13; chr8:55878463-56012447 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Chemically induced (ENU)(6) Targeted(8) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit splenomegaly, reduced numbers of peripheral B cells, impaired immune responses, IgM hyperglobulinemia, autoimmunity with glomerulonephritis, and monocyte/macrophage tumors.
 
Human Diseases Modeled in Mice Using Lyn (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(3)
Interactions
Lyn interacts with 225 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (128 annotations)
Process adaptive immune response, B cell homeostasis, ...
Component cell, cell-cell adherens junction, ...
Function ATP binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (76)    Tissues (75)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 30
RT-PCR 46
cDNA source data(92)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lyn ; ZFIN lyn    NEW 
Molecular
reagents
All nucleic(108) Genomic(12) cDNA(94) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000004398 (Evidence)
Ensembl Gene Model ENSMUSG00000042228 (Evidence)
Entrez Gene 17096 (Evidence)
UniGene 317331
DFCI TC1576685, TC1583714, TC1633161
DoTS DT.101311785, DT.101400667, DT.91597006, DT.99859329
NIA Mouse Gene Index U041317
EC 2.7.10.2
PDB 2ZV7, 2ZV8, 2ZV9, 2ZVA, 4TZI
Consensus CDS Project CCDS17939.1, CCDS51109.1
International Mouse Phenotyping Consortium Status Lyn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004398 VEGA Gene Model | MGI Sequence Detail 135008 C57BL/6J ±  kb
transcript OTTMUST00000009967 VEGA | MGI Sequence Detail 3463 Not Applicable 
polypeptide OTTMUSP00000004774 VEGA | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(8) UniProt(5)
Polymorphisms
RFLP(3) : SNPs within 2kb(1227 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1901)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 SH3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000010002 tyrosine-protein kinase Lyn
References
(Earliest) J:8639 Yamanashi Y, et al., The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol. 1987 Jan;7(1):237-43
(Latest) J:215994 Gelman IH, et al., Differential requirement for Src family tyrosine kinases in the initiation, progression, and metastasis of prostate cancer. Mol Cancer Res. 2014 Oct;12(10):1470-9
All references(261)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10668, MGD-MRK-12071, MGI:2140121

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory