Lyn
Gene Detail

Symbol Name ID

Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog MGI:96892

Synonyms

Hck-2

Feature Type

protein coding gene

Genetic Map

Chromosome 4

2.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr4:3678115-3813122 bp, + strand From VEGA annotation of GRCm38   135008 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55649  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Lyn

Human homologs

Human Homolog		LYN, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
NCBI Gene ID		4067
neXtProt AC		NX_P07948
Human Synonyms		JTK8, p53Lyn, p56Lyn
Human Chr (Location)		8q13; chr8:56792386-56925006 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(7) Chemically induced(2)
 

Homozygotes for targeted null mutations exhibit splenomegaly, reduced numbers of peripheral B cells, impaired immune responses, IgM hyperglobulinemia, autoimmunity with glomerulonephritis, and monocyte/macrophage tumors.

 
Human Diseases Modeled Using Mouse Lyn (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (119 annotations)

Process	apoptotic nuclear changes, B cell homeostasis, ...
Component	alpha2-beta1 integrin complex, cell, ...
Function	ATP binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28

Assay Type	Results
RT-PCR	46

cDNA source data(92)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(108) Genomic(12) cDNA(94) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000004398 (Evidence)
Ensembl Gene Model	ENSMUSG00000042228 (Evidence)
Entrez Gene	17096 (Evidence)
UniGene	317331
DFCI	TC1576685, TC1583714, TC1633161
DoTS	DT.101311785, DT.101400667, DT.91597006, DT.99859329
EC	2.7.10.2
PDB	2ZVA, 2ZV7, 2ZV8, 2ZV9
Consensus CDS Project	CCDS17939.1, CCDS51109.1
International Mouse Knockout Project Status	Lyn

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004398	VEGA Gene Model | MGI Sequence Detail	135008	C57BL/6J
transcript	OTTMUST00000009967	VEGA | MGI Sequence Detail	3463	Not Applicable
polypeptide	OTTMUSP00000004774	VEGA | MGI Sequence Detail	512	Not Applicable

All sequences(49) RefSeq(4) UniProt(5)

Polymorphisms

RFLP(3) : SNPs(603 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR000980	SH2 domain
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
Protein Ontology	PR:000010002	tyrosine-protein kinase Lyn

References

(Earliest) J:8639 Yamanashi Y, et al., The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol. 1987 Jan;7(1):237-43
(Latest) J:194836 Fumagalli L, et al., Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation. J Immunol. 2013 Apr 1;190(7):3648-60
All references(239)

Other accession IDs

MGD-MRK-10668, MGD-MRK-12071, MGI:2140121