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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lyn
LYN proto-oncogene, Src family tyrosine kinase
MGI:96892
45 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Blktm1Tara/\Blktm1Tara
\Fyntm1Sor/\Fyntm1Sor
\Lyntm1Ard/\Lyntm1Ard
either: B6.129-Lyntm1Ard Fyntm1Sor Blktm1Tara or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6) 		abnormal B cell differentiation J:115080
abnormal pro-B cell differentiation J:115080
arrested B cell differentiation J:115080
decreased B cell number J:115080
decreased immature B cell number J:115080
decreased pre-B cell number J:115080
\Cd19tm1Tft/\Cd19tm1Tft
\Lyntm1Sor/\Lyntm1Sor
involves: 129S4/SvJaeSor * C57BL/6 		abnormal humoral immune response J:71174
decreased anti-double stranded DNA antibody level J:71174
decreased B cell number J:71174
decreased B cell proliferation J:71174
decreased B-1 B cell number J:71174
decreased mature B cell number J:71174
decreased susceptibility to systemic lupus erythematosus J:71174
enlarged spleen J:71174
normal immune system phenotype J:71174
\Cd22tm1Eac/\Cd22+
\Lyntm1Ard/\Lyn+
\Ptpn6me-v/\Ptpn6+
\Tg(IghelMD4)4Ccg/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell negative selection J:110531
abnormal mature B cell morphology J:110531
increased IgM level J:110531
\Cd22tm1Eac/\Cd22+
\Lyntm1Ard/\Lyn+
\Tg(IghelMD4)4Ccg/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell negative selection J:110531
abnormal mature B cell morphology J:110531
\Fgrtm1Hev/\Fgrtm1Hev
\Hcktm1Hev/\Hcktm1Hev
\Lyntm1Sor/\Lyntm1Sor
B6.Cg-Hcktm1Hev Fgrtm1Hev Lyntm1Sor 		abnormal inflammatory response J:113463
abnormal neutrophil physiology J:113463
\Igh-7tm1Led/\Igh-7tm1Led
\Lyntm1Ard/\Lyntm1Ard
involves: 129P2/OlaHsd * 129S4/SvJae 		abnormal circulating complement protein level J:161523
decreased B cell number J:161523
increased anti-double stranded DNA antibody level J:161523
increased anti-nuclear antigen antibody level J:161523
increased basophil cell number J:161523
increased IgA level J:161523
increased IgM level J:161523
\Ightm1Mnz/\Ightm1Mnz
\Lyntm1Sor/\Lyntm1Sor
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 		abnormal B cell physiology J:75653
increased B cell proliferation J:75653
\Ightm2Mnz/\Ightm2Mnz
\Lyntm1Sor/\Lyntm1Sor
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 		abnormal B cell physiology J:75653
increased B cell proliferation J:75653
\Il4tm1Kopf/\Il4tm1Kopf
\Lyntm1Ard/\Lyntm1Ard
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal circulating complement protein level J:161523
decreased B cell number J:161523
decreased IgE level J:161523
decreased IgG1 level J:161523
increased anti-double stranded DNA antibody level J:161523
increased anti-nuclear antigen antibody level J:161523
increased basophil cell number J:161523
increased IgA level J:161523
increased IgG2a level J:161523
increased IgG2b level J:161523
increased IgM level J:161523
increased mast cell number J:161523
\Il5ratm1Ktk/\Il5ratm1Ktk
\Lyntm1Tya/\Lyntm1Tya
involves: 129P2/OlaHsd * C57BL/6 		abnormal immune system organ morphology J:91089
abnormal spleen B cell corona morphology J:91089
abnormal spleen white pulp morphology J:91089
decreased B-1 B cell number J:91089
enlarged lymph nodes J:91089
enlarged spleen J:91089
glomerulonephritis J:91089
increased anti-double stranded DNA antibody level J:91089
increased IgA level J:91089
increased IgM level J:91089
increased immunoglobulin level J:91089
\KitW-sh/\KitW-sh
\Lyntm1Ard/\Lyntm1Ard
involves: 101 * 129P2/OlaHsd * C3H/HeH 		abnormal circulating complement protein level J:161523
albuminuria J:161523
decreased B cell number J:161523
glomerulonephritis J:161523
increased anti-double stranded DNA antibody level J:161523
increased anti-nuclear antigen antibody level J:161523
increased basophil cell number J:161523
increased IgA level J:161523
increased IgE level J:161523
increased IgG2b level J:161523
increased IgM level J:161523
\Lynmld4/\Lynmld4
\Mpltm1Wsa/\Mpltm1Wsa
B6.129S1-Mpltm1Wsa 		decreased erythrocyte cell number J:144799
decreased leukocyte cell number J:144799
thrombocytopenia J:144799
\Lyntm1.1Calo/\Lyntm1.1Calo
\Myd88tm1Defr/\Myd88tm1Defr
\Tg(Itgax-cre)1-1Reiz/0
involves: 129P2/OlaHsd * C57BL/6 * CBA 		normal immune system phenotype J:200745
normal renal/urinary system phenotype J:200745
\Lyntm1Ard/\Lyn+
\Ptpn6me-v/\Ptpn6+
\Tg(IghelMD4)4Ccg/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal mature B cell morphology J:110531
\Lyntm1Ard/\Lyn+
\Tg(IghelMD4)4Ccg/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal mature B cell morphology J:110531
\Lyntm1Ard/\Lyntm1Ard
\Tg(IghelMD4)4Ccg/0
involves: 129P2/OlaHsd * C57BL/6 		abnormal B cell activation J:110531
abnormal B cell negative selection J:110531
abnormal mature B cell morphology J:110531
absent B-1 B cells J:110531
increased IgM level J:110531
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory