Phenotypes Associated with This Genotype

Genotype
MGI:3767995

• Allelic Composition: Lyn^tm1Ard/Lyn^tm1Ard
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:72269 )

• mice develop age-dependent splenomegaly

• 20% of mice greater than 1 year of age exhibit severe splenomegaly with partial to complete replacement of red and white pulp with myelomonocytic cells that are often centers of extramedullary hematopoiesis

extramedullary hematopoiesis ( J:72269 )

• red and white pulp are often replaced with of red and white pulp with myelomonocytic cells that are often centers of extramedullary hematopoiesis

• myelomonocytic cells often accumulate in other organs and on the surface of the ears, tails and legs

increased basophil cell number ( J:161523 )

• in cervical and inguinal lymph nodes and spleen

increased mast cell number ( J:161523 )

• in the peritoneum

increased neutrophil cell number ( J:72269 )

• mice exhibit decreased platelet numbers that becomes more pronounced with age (at 6 to 8 weeks in peripheral blood, 1089+/-242 per ul compared to 609+/-207 per ul in wild-type mice; at 52 to 58 weeks in peripheral blood, 2540+/-1050 per ul compared to 1264+/-434 per ul in wild-type mice)

thrombocytopenia ( J:72269 )

decreased spleen red pulp amount ( J:72269 )

• red and white pulp are often replaced with myelomonocytic cells that are often centers of extramedullary hematopoiesis

decreased spleen white pulp amount ( J:72269 )

• red and white pulp are often replaced with myelomonocytic cells that are often centers of extramedullary hematopoiesis

increased IgA level ( J:161523 )

increased IgE level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

immune system

enlarged spleen ( J:72269 )

• mice develop age-dependent splenomegaly

• 20% of mice greater than 1 year of age exhibit severe splenomegaly with partial to complete replacement of red and white pulp with myelomonocytic cells that are often centers of extramedullary hematopoiesis

increased basophil cell number ( J:161523 )

• in cervical and inguinal lymph nodes and spleen

increased mast cell number ( J:161523 )

• in the peritoneum

increased neutrophil cell number ( J:72269 )

• mice exhibit decreased platelet numbers that becomes more pronounced with age (at 6 to 8 weeks in peripheral blood, 1089+/-242 per ul compared to 609+/-207 per ul in wild-type mice; at 52 to 58 weeks in peripheral blood, 2540+/-1050 per ul compared to 1264+/-434 per ul in wild-type mice)

decreased spleen red pulp amount ( J:72269 )

• red and white pulp are often replaced with myelomonocytic cells that are often centers of extramedullary hematopoiesis

decreased spleen white pulp amount ( J:72269 )

• red and white pulp are often replaced with myelomonocytic cells that are often centers of extramedullary hematopoiesis

increased IgA level ( J:161523 )

increased IgE level ( J:161523 )

increased IgG2b level ( J:161523 )

increased IgM level ( J:161523 )

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

abnormal level of surface class II molecules ( J:161523 )

• basophils show high MHC II expression

increased anti-nuclear antigen antibody level ( J:161523 )

• of IgE isotype

increased anti-double stranded DNA antibody level ( J:161523 )

• of IgE isotype

glomerulonephritis ( J:161523 )

homeostasis/metabolism

abnormal circulating complement protein level ( J:161523 )

• increased circulating immune complexes reactive to complement component 1 q

albuminuria ( J:161523 )

• elevated albumin-to-creatinine ratio

renal/urinary system

albuminuria ( J:161523 )

• elevated albumin-to-creatinine ratio

glomerulonephritis ( J:161523 )

growth/size/body

enlarged spleen ( J:72269 )

• mice develop age-dependent splenomegaly

• 20% of mice greater than 1 year of age exhibit severe splenomegaly with partial to complete replacement of red and white pulp with myelomonocytic cells that are often centers of extramedullary hematopoiesis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:161523